KEGG   PATHWAY: pbi00564
Entry
pbi00564                    Pathway                                
Name
Glycerophospholipid metabolism - Python bivittatus (Burmese python)
Class
Metabolism; Lipid metabolism
Pathway map
pbi00564  Glycerophospholipid metabolism
pbi00564

Module
pbi_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:pbi00564]
pbi_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:pbi00564]
pbi_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:pbi00564]
Other DBs
GO: 0006650
Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103048104  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
103048243  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
103048717  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
103049142  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
103049233  [KO:K01047] [EC:3.1.1.4]
103049234  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103049416  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X3 [KO:K00006] [EC:1.1.1.8]
103049543  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
103049578  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
103049750  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
103049777  [KO:K00901] [EC:2.7.1.107]
103049864  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
103050394  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
103050635  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103050683  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
103050937  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
103051286  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
103051812  DGKZ; diacylglycerol kinase zeta isoform X2 [KO:K00901] [EC:2.7.1.107]
103051992  [KO:K16342] [EC:3.1.1.4]
103052333  [KO:K16342] [EC:3.1.1.4]
103052346  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
103052468  [KO:K16342] [EC:3.1.1.4]
103052835  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
103052871  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
103052994  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
103053222  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
103053767  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
103053871  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
103053874  [KO:K00006] [EC:1.1.1.8]
103054374  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
103054426  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
103054600  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
103054616  [KO:K00901] [EC:2.7.1.107]
103054819  MBOAT1; lysophospholipid acyltransferase 1 isoform X2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
103055003  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103055075  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
103055154  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103055208  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
103055342  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
103056089  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
103056111  [KO:K18693] [EC:3.6.1.75 3.1.3.4]
103056206  [KO:K01049] [EC:3.1.1.7]
103056269  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
103056372  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103056469  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
103056612  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
103056616  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
103056741  PNPLA6; neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
103056998  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103057232  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103057257  [KO:K01047] [EC:3.1.1.4]
103057730  [KO:K01047] [EC:3.1.1.4]
103057841  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
103057915  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
103058113  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
103058262  [KO:K00901] [EC:2.7.1.107]
103058382  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
103058714  [KO:K13509] [EC:2.3.1.51]
103058788  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
103058932  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
103059060  [KO:K13516] [EC:2.3.1.-]
103059167  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
103059196  [KO:K13509] [EC:2.3.1.51]
103059779  [KO:K16342] [EC:3.1.1.4]
103060071  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
103060155  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103060169  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
103060758  [KO:K00981] [EC:2.7.7.41]
103061495  PLD4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
103061591  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
103061793  [KO:K00623] [EC:2.3.1.6]
103061859  [KO:K16342] [EC:3.1.1.4]
103062091  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103062247  [KO:K05929] [EC:2.1.1.103]
103062440  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103062442  [KO:K01047] [EC:3.1.1.4]
103062530  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
103062756  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103062877  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
103062927  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
103062932  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
103063137  [KO:K01047] [EC:3.1.1.4]
103063284  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103063430  PLPP5; phospholipid phosphatase 5 isoform X2 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
103063432  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
103063562  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
103063654  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
103063659  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
103063722  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
103063776  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
103063911  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
103064175  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
103064252  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
103064355  [KO:K00006] [EC:1.1.1.8]
103064689  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
103064697  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
103064795  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
103065039  [KO:K00623] [EC:2.3.1.6]
103065044  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
103065282  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
103065340  [KO:K16342] [EC:3.1.1.4]
103065591  [KO:K16342] [EC:3.1.1.4]
103065726  [KO:K16342] [EC:3.1.1.4]
103065836  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
103066549  SAMD8; sphingomyelin synthase-related protein 1 isoform X3 [KO:K22697] [EC:3.1.4.62]
103066652  [KO:K13516] [EC:2.3.1.-]
103066713  [KO:K16342] [EC:3.1.1.4]
103066761  [KO:K13516] [EC:2.3.1.-]
103066807  [KO:K16342] [EC:3.1.1.4]
103066843  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
103067131  [KO:K14156] [EC:2.7.1.32 2.7.1.82]
103067448  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
103067613  [KO:K16342] [EC:3.1.1.4]
103067734  [KO:K16860] [EC:3.1.4.4]
103067987  [KO:K01080] [EC:3.1.3.4]
103067991  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
103068245  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
112541572  [KO:K01047] [EC:3.1.1.4]
112541980  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
pbi00010  Glycolysis / Gluconeogenesis
pbi00260  Glycine, serine and threonine metabolism
pbi00561  Glycerolipid metabolism
pbi00562  Inositol phosphate metabolism
pbi00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
pbi00565  Ether lipid metabolism
pbi00620  Pyruvate metabolism
KO pathway
ko00564   

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