KEGG   PATHWAY: pcw00330
Entry
pcw00330                    Pathway                                
Name
Arginine and proline metabolism - Phascolarctos cinereus (koala)
Class
Metabolism; Amino acid metabolism
Pathway map
pcw00330  Arginine and proline metabolism
pcw00330

Module
pcw_M00015  Proline biosynthesis, glutamate => proline [PATH:pcw00330]
pcw_M00047  Creatine pathway [PATH:pcw00330]
pcw_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:pcw00330]
pcw_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:pcw00330]
pcw_M00970  Proline degradation, proline => glutamate [PATH:pcw00330]
pcw_M00972  Proline metabolism [PATH:pcw00330]
Other DBs
GO: 0006525 0006560
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110223693  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
110223482  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
110197349  CKB; creatine kinase B-type isoform X1 [KO:K00933] [EC:2.7.3.2]
110222607  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
110223738  CKMT1A; creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
110203641  CKM; creatine kinase M-type isoform X1 [KO:K27382] [EC:2.7.3.2]
110206238  AZIN2; LOW QUALITY PROTEIN: antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
110212680  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
110206237  antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
110199252  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
110210823  SMS; LOW QUALITY PROTEIN: spermine synthase [KO:K00802] [EC:2.5.1.22]
110222868  AMD1; LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
110201979  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
110218400  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
110196807  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
110222089  ALDH3A2; fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
110220571  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
110219698  ALDH16A1; LOW QUALITY PROTEIN: aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
110223911  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110202730  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
110215824  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
110215842  CNDP2; LOW QUALITY PROTEIN: cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
110195424  CARNS1; LOW QUALITY PROTEIN: carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
110193004  SATL1; spermidine/spermine N(1)-acetyltransferase-like protein 1 [KO:K00657] [EC:2.3.1.57]
110194420  SAT2; diamine acetyltransferase 2 isoform X1 [KO:K00657] [EC:2.3.1.57]
110210810  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
110214802  MAOA; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
110214856  amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
110198797  AGMAT; agmatinase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
110222812  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
110192171  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110201937  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110220628  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
110208873  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
110198965  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
110214294  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
110205520  PYCR2; pyrroline-5-carboxylate reductase 2 isoform X1 [KO:K00286] [EC:1.5.1.2]
110218326  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial [KO:K00286] [EC:1.5.1.2]
110215232  proline dehydrogenase 1, mitochondrial-like [KO:K00318] [EC:1.5.5.2]
110198709  ALDH4A1; LOW QUALITY PROTEIN: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
110215463  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
110212709  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
110211708  P4HA2; prolyl 4-hydroxylase subunit alpha-2 [KO:K00472] [EC:1.14.11.2]
110221448  P4HA1; LOW QUALITY PROTEIN: prolyl 4-hydroxylase subunit alpha-1 [KO:K00472] [EC:1.14.11.2]
110210588  P4HA3; prolyl 4-hydroxylase subunit alpha-3 [KO:K00472] [EC:1.14.11.2]
110201606  PRODH2; probable proline dehydrogenase 2 isoform X1 [KO:K11394] [EC:1.5.5.3]
110215368  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
110207741  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
110192416  GOT2; LOW QUALITY PROTEIN: aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
110215427  HOGA1; LOW QUALITY PROTEIN: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
110222852  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
110208425  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
pcw00020  Citrate cycle (TCA cycle)
pcw00220  Arginine biosynthesis
pcw00250  Alanine, aspartate and glutamate metabolism
pcw00260  Glycine, serine and threonine metabolism
pcw00270  Cysteine and methionine metabolism
pcw00310  Lysine degradation
pcw00410  beta-Alanine metabolism
pcw00470  D-Amino acid metabolism
pcw00480  Glutathione metabolism
pcw00630  Glyoxylate and dicarboxylate metabolism
pcw00650  Butanoate metabolism
pcw00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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