KEGG   PATHWAY: pfv00260
Entry
pfv00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas fulva
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pfv00260  Glycine, serine and threonine metabolism
pfv00260

Module
pfv_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pfv00260]
pfv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pfv00260]
pfv_M00555  Betaine biosynthesis, choline => betaine [PATH:pfv00260]
pfv_M00621  Glycine cleavage system [PATH:pfv00260]
pfv_M00919  Ectoine degradation, ectoine => aspartate [PATH:pfv00260]
pfv_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pfv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas fulva [GN:pfv]
Gene
Psefu_3125  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Psefu_3072  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Psefu_1048  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Psefu_4315  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Psefu_1049  threonine synthase [KO:K01733] [EC:4.2.3.1]
Psefu_4232  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Psefu_3127  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Psefu_4229  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Psefu_2155  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Psefu_3733  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Psefu_3387  Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
Psefu_1097  Hydroxypyruvate reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Psefu_3334  glycerate kinase [KO:K00865] [EC:2.7.1.165]
Psefu_3906  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Psefu_1698  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Psefu_4293  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Psefu_2017  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Psefu_4123  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Psefu_2141  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
Psefu_1021  Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
Psefu_0501  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Psefu_1020  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Psefu_2491  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Psefu_0502  Glycine cleavage system H protein [KO:K02437]
Psefu_1022  Glycine cleavage system H protein [KO:K02437]
Psefu_0865  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Psefu_4140  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Psefu_4139  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Psefu_4234  Rieske (2Fe-2S) iron-sulfur domain protein [KO:K00479] [EC:1.14.13.251]
Psefu_4233  Nitric oxide dioxygenase [KO:K21832] [EC:1.14.13.251]
Psefu_4242  2,4-dienoyl-CoA reductase (NADPH) [KO:K21833] [EC:1.5.7.3]
Psefu_4243  protein of unknown function DUF224 cysteine-rich region domain protein [KO:K21834]
Psefu_4244  Electron transfer flavoprotein alpha subunit [KO:K25960]
Psefu_4245  Electron transfer flavoprotein alpha/beta-subunit [KO:K25961]
Psefu_4366  Sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Psefu_4226  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Psefu_4228  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Psefu_4225  sarcosine oxidase, gamma subunit family [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Psefu_4227  sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Psefu_4147  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Psefu_0027  ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
Psefu_0789  Threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Psefu_4287  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Psefu_0475  aspartate racemase [KO:K25316] [EC:5.1.1.10]
Psefu_0144  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Psefu_0145  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Psefu_2387  2,4-diaminobutyrate 4-transaminase [KO:K00836] [EC:2.6.1.76]
Psefu_0029  ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
Psefu_0030  ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
Psefu_0036  Acetylornithine transaminase [KO:K15785] [EC:2.6.1.76]
Psefu_0035  Succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pfv00010  Glycolysis / Gluconeogenesis
pfv00020  Citrate cycle (TCA cycle)
pfv00230  Purine metabolism
pfv00250  Alanine, aspartate and glutamate metabolism
pfv00270  Cysteine and methionine metabolism
pfv00290  Valine, leucine and isoleucine biosynthesis
pfv00300  Lysine biosynthesis
pfv00330  Arginine and proline metabolism
pfv00460  Cyanoamino acid metabolism
pfv00470  D-Amino acid metabolism
pfv00564  Glycerophospholipid metabolism
pfv00620  Pyruvate metabolism
pfv00630  Glyoxylate and dicarboxylate metabolism
pfv00640  Propanoate metabolism
pfv00680  Methane metabolism
pfv00860  Porphyrin metabolism
pfv00920  Sulfur metabolism
KO pathway
ko00260   
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