KEGG   PATHWAY: pfx00260
Entry
pfx00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas lurida
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pfx00260  Glycine, serine and threonine metabolism
pfx00260

Module
pfx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pfx00260]
pfx_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pfx00260]
pfx_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pfx00260]
pfx_M00555  Betaine biosynthesis, choline => betaine [PATH:pfx00260]
pfx_M00621  Glycine cleavage system [PATH:pfx00260]
pfx_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pfx00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas lurida [GN:pfx]
Gene
A7318_20585  aspartate kinase [KO:K00928] [EC:2.7.2.4]
A7318_17755  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A7318_22260  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
A7318_27775  homoserine kinase [KO:K02204] [EC:2.7.1.39]
A7318_19890  phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
A7318_22265  threonine synthase [KO:K01733] [EC:4.2.3.1]
A7318_20595  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A7318_24995  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A7318_24985  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A7318_23305  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A7318_03960  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
A7318_04170  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
A7318_13200  glycerate kinase [KO:K00865] [EC:2.7.1.165]
A7318_07975  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
A7318_00975  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
A7318_25825  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A7318_07250  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
A7318_02520  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
A7318_17255  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
A7318_22780  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
A7318_22770  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A7318_26035  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A7318_08085  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A7318_16955  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A7318_22785  glycine cleavage system protein H [KO:K02437]
A7318_26030  glycine cleavage system protein H [KO:K02437]
A7318_14010  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
A7318_22845  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A7318_25135  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
A7318_25130  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7318_06670  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7318_25010  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
A7318_25005  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
A7318_25030  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
A7318_25025  (Fe-S)-binding protein [KO:K21834]
A7318_25020  electron transfer flavoprotein subunit alpha [KO:K25960]
A7318_25015  electron transfer flavoprotein subunit beta [KO:K25961]
A7318_17990  N-methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
A7318_24970  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
A7318_24980  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
A7318_24965  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
A7318_24975  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
A7318_08950  methyltransferase [KO:K18896] [EC:2.1.1.156]
A7318_12360  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
A7318_12355  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
A7318_04505  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A7318_22775  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A7318_25100  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A7318_25795  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A7318_11385  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
A7318_13215  racemase [KO:K25316] [EC:5.1.1.10]
A7318_27565  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A7318_27570  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A7318_18625  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
A7318_12000  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pfx00010  Glycolysis / Gluconeogenesis
pfx00020  Citrate cycle (TCA cycle)
pfx00230  Purine metabolism
pfx00250  Alanine, aspartate and glutamate metabolism
pfx00270  Cysteine and methionine metabolism
pfx00290  Valine, leucine and isoleucine biosynthesis
pfx00300  Lysine biosynthesis
pfx00330  Arginine and proline metabolism
pfx00460  Cyanoamino acid metabolism
pfx00470  D-Amino acid metabolism
pfx00564  Glycerophospholipid metabolism
pfx00620  Pyruvate metabolism
pfx00630  Glyoxylate and dicarboxylate metabolism
pfx00640  Propanoate metabolism
pfx00680  Methane metabolism
pfx00860  Porphyrin metabolism
pfx00920  Sulfur metabolism
KO pathway
ko00260   
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