KEGG   PATHWAY: pgig04612
Entry
pgig04612                   Pathway                                
Name
Antigen processing and presentation - Pteropus giganteus (Indian flying fox)
Class
Organismal Systems; Immune system
Pathway map
pgig04612  Antigen processing and presentation
pgig04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120604831  IFNG; interferon gamma [KO:K04687]
120618944  TNF; tumor necrosis factor [KO:K03156]
120608513  PSME1; proteasome activator complex subunit 1 [KO:K06696]
120608514  PSME2; proteasome activator complex subunit 2 isoform X1 [KO:K06697]
120584190  proteasome activator complex subunit 3-like [KO:K06698]
120611070  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
120618906  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
120618910  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
120618911  heat shock 70 kDa protein 1-like [KO:K03283]
120612399  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
120612741  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
120581279  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
120596182  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
120619712  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
120613145  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
120592308  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
120592320  saoe class I histocompatibility antigen, C alpha chain-like [KO:K06751]
120592626  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
120615897  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
120616337  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
120616593  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
120606422  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
120618951  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
120599497  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
120589178  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
120589505  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
120601748  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
120616625  CANX; calnexin [KO:K08054]
120622700  B2M; beta-2-microglobulin [KO:K08055]
120622712  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
120618527  CALR; calreticulin [KO:K08057]
120597649  tapasin isoform X1 [KO:K08058]
120597635  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
120597640  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
120594587  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
120594517  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
120589132  uncharacterized protein LOC120589132 [KO:K10785]
120592785  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120592786  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120592787  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120583089  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120618063  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120618065  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
120618066  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120618067  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120618068  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120586545  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
120603037  natural killer cells antigen CD94-like [KO:K06516]
120614215  natural killer cells antigen CD94-like [KO:K06516]
120614216  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
120584395  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
120618064  natural killer cells antigen CD94-like [KO:K06516]
120618074  natural killer cells antigen CD94-like [KO:K06516]
120607034  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
120611025  natural killer cells antigen CD94-like [KO:K06516]
120611725  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
120606551  IFI30; gamma-interferon-inducible lysosomal thiol reductase isoform X1 [KO:K08059]
120619626  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
120613356  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
120597570  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
120597603  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
120597605  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
120597654  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
120597655  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
120597657  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
120597658  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
120597659  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
120597661  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120597662  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
120597678  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
120597680  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120581555  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
120612928  CTSL; LOW QUALITY PROTEIN: procathepsin L [KO:K01365] [EC:3.4.22.15]
120591553  procathepsin L [KO:K01365] [EC:3.4.22.15]
120616912  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120617128  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120585211  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
120611664  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
120620383  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
120585231  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
120606585  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
120610613  LOW QUALITY PROTEIN: regulatory factor X-associated protein [KO:K08063]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120596171  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
120614941  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
120614022  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
pgig03050  Proteasome
pgig04650  Natural killer cell mediated cytotoxicity
pgig04660  T cell receptor signaling pathway
KO pathway
ko04612   
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