KEGG   PATHWAY: plg00260
Entry
plg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paucimonas lemoignei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
plg00260  Glycine, serine and threonine metabolism
plg00260

Module
plg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:plg00260]
plg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:plg00260]
plg_M00555  Betaine biosynthesis, choline => betaine [PATH:plg00260]
plg_M00621  Glycine cleavage system [PATH:plg00260]
plg_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:plg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paucimonas lemoignei [GN:plg]
Gene
NCTC10937_03861  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
NCTC10937_03316  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NCTC10937_01407  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NCTC10937_00089  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
NCTC10937_01408  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NCTC10937_00537  ltaE_1; threonine aldolase, low-specificity [KO:K01620] [EC:4.1.2.48]
NCTC10937_03863  ltaE_2; Threonine aldolase [KO:K01620] [EC:4.1.2.48]
NCTC10937_00530  glyA2; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCTC10937_00922  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCTC10937_04358  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
NCTC10937_02677  ghrA_2; D-isomer specific 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NCTC10937_04612  ghrA_4; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NCTC10937_04307  ghrB_2; 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NCTC10937_02201  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
NCTC10937_00447  gpmI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
NCTC10937_00476  serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCTC10937_03178  serA_2; putative hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCTC10937_03986  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NCTC10937_00738  serB_2; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
NCTC10937_00437  puo; amine oxidase, flavin-containing protein [KO:K00274] [EC:1.4.3.4]
NCTC10937_04243  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NCTC10937_04244  gcvT2; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
NCTC10937_05106  gcvT_2; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
NCTC10937_03288  lpdG; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCTC10937_05253  lpd3; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCTC10937_04242  gcvH_1; glycine cleavage system protein H [KO:K02437]
NCTC10937_05107  gcvH_2; protein GcvH [KO:K02437]
NCTC10937_01901  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
NCTC10937_04474  pssA_2; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
NCTC10937_00665  betA_1; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NCTC10937_00666  betB_1; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NCTC10937_00542  antA_1; Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
NCTC10937_02142  antA_2; iron-sulfur cluster-binding protein, rieske family [KO:K00479] [EC:1.14.13.251]
NCTC10937_00541  hcr; ferredoxin:oxidoreductase FAD/NAD(P)-binding subunit [KO:K21832] [EC:1.14.13.251]
NCTC10937_00373  dimethylglycine catabolism protein DgcA [KO:K21833] [EC:1.5.7.3]
NCTC10937_00374  putative iron-binding membrane protein [KO:K21834]
NCTC10937_00375  etfA_1; electron transfer flavoprotein subunit alpha [KO:K25960]
NCTC10937_00376  electron transfer flavoprotein subunit beta [KO:K25961]
NCTC10937_03454  soxA1; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NCTC10937_00527  gcvT_1; sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NCTC10937_00529  soxB_2; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NCTC10937_03452  soxB_5; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NCTC10937_03455  sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
NCTC10937_00526  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
NCTC10937_00528  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
NCTC10937_03453  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
NCTC10937_04420  sdaA; Iron-sulfur-dependent L-serine dehydratase single chain form [KO:K01752] [EC:4.3.1.17]
NCTC10937_01759  ilvA_1; L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
NCTC10937_01987  ilvA_2; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NCTC10937_00482  ilvA-2; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NCTC10937_03056  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
NCTC10937_02781  D-serine deaminase [KO:K01753] [EC:4.3.1.18]
NCTC10937_00026  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NCTC10937_00027  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
NCTC10937_03965  dat; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
plg00010  Glycolysis / Gluconeogenesis
plg00020  Citrate cycle (TCA cycle)
plg00230  Purine metabolism
plg00250  Alanine, aspartate and glutamate metabolism
plg00270  Cysteine and methionine metabolism
plg00290  Valine, leucine and isoleucine biosynthesis
plg00300  Lysine biosynthesis
plg00330  Arginine and proline metabolism
plg00460  Cyanoamino acid metabolism
plg00470  D-Amino acid metabolism
plg00564  Glycerophospholipid metabolism
plg00620  Pyruvate metabolism
plg00630  Glyoxylate and dicarboxylate metabolism
plg00640  Propanoate metabolism
plg00680  Methane metabolism
plg00860  Porphyrin metabolism
plg00920  Sulfur metabolism
KO pathway
ko00260   
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