KEGG   PATHWAY: pmot00260
Entry
pmot00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas monteilii SB3101
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pmot00260  Glycine, serine and threonine metabolism
pmot00260

Module
pmot_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pmot00260]
pmot_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pmot00260]
pmot_M00555  Betaine biosynthesis, choline => betaine [PATH:pmot00260]
pmot_M00621  Glycine cleavage system [PATH:pmot00260]
pmot_M00919  Ectoine degradation, ectoine => aspartate [PATH:pmot00260]
pmot_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pmot00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas monteilii SB3101 [GN:pmot]
Gene
X970_18010  aspartokinase [KO:K00928] [EC:2.7.2.4]
X970_05870  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
X970_03735  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
X970_01720  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
X970_26270  homoserine kinase [KO:K02204] [EC:2.7.1.39]
X970_03740  threonine synthase [KO:K01733] [EC:4.2.3.1]
X970_01710  threonine synthase [KO:K01733] [EC:4.2.3.1]
X970_27420  threonine aldolase [KO:K01620] [EC:4.1.2.48]
X970_27425  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
X970_01740  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
X970_02300  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
X970_21445  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
X970_12725  glycerate kinase [KO:K00865] [EC:2.7.1.165]
X970_17405  TtuD3 hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
X970_23830  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
X970_24345  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
X970_06745  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
X970_04945  MFS transporter [KO:K00831] [EC:2.6.1.52]
X970_23105  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
X970_00845  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
X970_23475  amine oxidase [KO:K00274] [EC:1.4.3.4]
X970_24555  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
X970_03290  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
X970_24565  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
X970_03280  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
X970_25420  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
X970_16805  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
X970_17935  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
X970_24560  glycine cleavage system protein H [KO:K02437]
X970_03295  glycine cleavage system protein H [KO:K02437]
X970_09365  creatininase [KO:K08688] [EC:3.5.3.3]
X970_14890  phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
X970_02140  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
X970_21925  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
X970_23870  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
X970_23865  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
X970_01950  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
X970_27390  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
X970_27395  ferredoxin [KO:K21832] [EC:1.14.13.251]
X970_27365  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
X970_27370  (Fe-S)-binding protein [KO:K21834]
X970_27375  electron transfer flavoprotein subunit alpha [KO:K25960]
X970_27380  electron transfer flavoprotein subunit beta [KO:K25961]
X970_27440  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
X970_15385  aminomethyltransferase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
X970_27430  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
X970_15375  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
X970_15390  sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
X970_27445  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
X970_27435  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
X970_15380  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
X970_18945  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
X970_27290  serine dehydratase [KO:K01752] [EC:4.3.1.17]
X970_03285  serine dehydratase [KO:K01752] [EC:4.3.1.17]
X970_12915  serine dehydratase [KO:K01752] [EC:4.3.1.17]
X970_01995  eutB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
X970_13620  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
X970_24315  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
X970_13940  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
X970_14950  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
X970_14985  alanine racemase [KO:K25317] [EC:5.1.1.10]
X970_26070  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
X970_26075  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
X970_16955  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
X970_02005  X-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
X970_02010  deacylase [KO:K15784] [EC:3.5.1.125]
X970_02020  aminotransferase [KO:K15785] [EC:2.6.1.76]
X970_02015  aldehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pmot00010  Glycolysis / Gluconeogenesis
pmot00020  Citrate cycle (TCA cycle)
pmot00230  Purine metabolism
pmot00250  Alanine, aspartate and glutamate metabolism
pmot00270  Cysteine and methionine metabolism
pmot00290  Valine, leucine and isoleucine biosynthesis
pmot00300  Lysine biosynthesis
pmot00330  Arginine and proline metabolism
pmot00460  Cyanoamino acid metabolism
pmot00470  D-Amino acid metabolism
pmot00564  Glycerophospholipid metabolism
pmot00620  Pyruvate metabolism
pmot00630  Glyoxylate and dicarboxylate metabolism
pmot00640  Propanoate metabolism
pmot00680  Methane metabolism
pmot00860  Porphyrin metabolism
pmot00920  Sulfur metabolism
KO pathway
ko00260   
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