KEGG   PATHWAY: ppyg03013
Entry
ppyg03013                   Pathway                                
Name
Nucleocytoplasmic transport - Pongo pygmaeus (Bornean orangutan)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ppyg03013  Nucleocytoplasmic transport
ppyg03013

Other DBs
GO: 0050658
Organism
Pongo pygmaeus (Bornean orangutan) [GN:ppyg]
Gene
129006806  IPO13; importin-13 isoform X1 [KO:K25202]
129007910  IPO7; importin-7 isoform X1 [KO:K20223]
129007997  NUP160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
129008199  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X3 [KO:K14297]
129008316  NXF1; nuclear RNA export factor 1 isoform X2 [KO:K14284]
129009300  PYM1; partner of Y14 and mago isoform X2 [KO:K14294]
129009418  XPOT; exportin-T isoform X2 [KO:K14288]
129009496  IPO8; importin-8 isoform X1 [KO:K18755]
129009678  AAAS; aladin isoform X1 [KO:K14320]
129009947  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
129010047  RAN; GTP-binding nuclear protein Ran [KO:K07936]
129010728  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
129010936  NUP37; nucleoporin Nup37 [KO:K14302]
129011260  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
129011284  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
129011446  IPO5; importin-5 [KO:K20222]
129011600  KPNA3; importin subunit alpha-4 [KO:K23583]
129011839  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
129011888  XPO4; exportin-4 isoform X1 [KO:K25203]
129012145  [KO:K12877]
129012789  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
129012848  IPO4; importin-4 isoform X2 [KO:K20221]
129013090  PNN; pinin [KO:K13114]
129013615  SNUPN; snurportin-1 isoform X2 [KO:K13151]
129013989  TPR; nucleoprotein TPR [KO:K09291]
129014088  [KO:K12160]
129015090  XPO6; exportin-6 isoform X5 [KO:K25204]
129015308  NUP93; nuclear pore complex protein Nup93 isoform X3 [KO:K14309]
129015421  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
129015449  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
129015509  THOC6; THO complex subunit 6 homolog [KO:K13175]
129015752  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
129015754  [KO:K18655] [EC:5.6.2.7]
129015982  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
129016631  KPNB1; importin subunit beta-1 [KO:K14293]
129016716  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
129016718  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
129017094  [KO:K12877]
129017354  EIF4A3; eukaryotic initiation factor 4A-III isoform X2 [KO:K13025] [EC:5.6.2.7]
129017525  [KO:K18752]
129018145  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
129018219  KPNA2; importin subunit alpha-1 [KO:K15043]
129018224  ALYREF; THO complex subunit 4 [KO:K12881]
129018287  CASC3; protein CASC3 [KO:K14323]
129018361  [KO:K12160]
129018627  SEH1L; nucleoporin SEH1 [KO:K14299]
129018659  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
129018955  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
129019465  IPO9; importin-9 isoform X1 [KO:K20224]
129020171  TNPO2; transportin-2 isoform X1 [KO:K18727]
129020474  NUP62; nuclear pore glycoprotein P62 [KO:K14306]
129020492  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
129020531  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
129021015  [KO:K12172] [EC:2.3.2.-]
129021490  RAE1; mRNA export factor RAE1 [KO:K14298]
129021564  NXT1; NTF2-related export protein 1 [KO:K14285]
129021674  CSE1L; exportin-2 isoform X1 [KO:K18423]
129021883  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
129022007  [KO:K12160]
129022407  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
129023223  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
129023301  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
129023486  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
129023802  [KO:K14284]
129023831  [KO:K03231]
129024264  THOC2; THO complex subunit 2 isoform X4 [KO:K12879]
129024333  [KO:K14284]
129024613  NXF3; nuclear RNA export factor 3 isoform X1 [KO:K14284]
129024616  [KO:K12160]
129024627  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
129025009  [KO:K14284]
129025177  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
129025212  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
129026926  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
129027984  XPO1; exportin-1 isoform X1 [KO:K14290]
129028448  [KO:K12172] [EC:2.3.2.-]
129028707  [KO:K12172] [EC:2.3.2.-]
129030225  [KO:K12172] [EC:2.3.2.-]
129030494  [KO:K12172] [EC:2.3.2.-]
129030698  [KO:K03231]
129030762  [KO:K12172] [EC:2.3.2.-]
129030767  [KO:K12172] [EC:2.3.2.-]
129030865  [KO:K12172] [EC:2.3.2.-]
129030866  [KO:K12172] [EC:2.3.2.-]
129032031  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
129032103  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
129032148  [KO:K14324]
129032685  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
129032755  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
129033205  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
129033380  AHCTF1; protein ELYS isoform X4 [KO:K25129]
129033593  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
129033743  KPNA4; importin subunit alpha-3 [KO:K23583]
129034082  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
129034240  KPNA1; importin subunit alpha-5 [KO:K23940]
129035209  TMEM33; transmembrane protein 33 [KO:K20724]
129035363  [KO:K07936]
129035526  NUP54; nucleoporin P54 [KO:K14308]
129036040  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
129036121  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
129036303  THOC3; THO complex subunit 3 [KO:K12880]
129036317  MAGOH; protein mago nashi homolog [KO:K12877]
129036700  IPO11; importin-11 isoform X2 [KO:K25201]
129036706  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
129036712  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
129036902  [KO:K12160]
129037593  TNPO1; transportin-1 isoform X1 [KO:K18752]
129037851  [KO:K03231]
129038010  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
129038043  POM121L2; POM121-like protein 2 [KO:K14316]
129038250  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
129038271  SUMO4; LOW QUALITY PROTEIN: small ubiquitin-related modifier 4 [KO:K12160]
129038616  KPNA5; importin subunit alpha-6 isoform X4 [KO:K15042]
129038679  NUP43; nucleoporin Nup43 [KO:K14305]
129039312  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
129039467  XPO5; exportin-5 isoform X1 [KO:K14289]
129040016  NUP205; nuclear pore complex protein Nup205 isoform X2 [KO:K14310]
129040029  POM121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
129040079  [KO:K12160]
129040098  [KO:K12160]
129040213  [KO:K14293]
129040388  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
129040422  [KO:K12160]
129040506  [KO:K12160]
129040840  [KO:K12160]
129041204  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
129041524  [KO:K12160]
129041677  KPNA7; importin subunit alpha-8 [KO:K15043]
129041717  TNPO3; transportin-3 isoform X1 [KO:K15436]
129042275  XPO7; exportin-7 [KO:K18460]
129042925  [KO:K03231]
129043405  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
129043561  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
129043878  GLE1; mRNA export factor GLE1 [KO:K18723]
129043894  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
129044326  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
129044942  [KO:K12160]
129045204  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ppyg03015  mRNA surveillance pathway
KO pathway
ko03013   

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