KEGG   PATHWAY: ppyg03440
Entry
ppyg03440                   Pathway                                
Name
Homologous recombination - Pongo pygmaeus (Bornean orangutan)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ppyg03440  Homologous recombination
ppyg03440

Other DBs
GO: 0000724
Organism
Pongo pygmaeus (Bornean orangutan) [GN:ppyg]
Gene
129007098  POLD4; DNA polymerase delta subunit 4 isoform X1 [KO:K03505]
129007517  MRE11; double-strand break repair protein MRE11 isoform X5 [KO:K10865]
129008408  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
129008564  POLD3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
129008963  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
129009537  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
129010962  SYCP3; synaptonemal complex protein 3 [KO:K19528]
129011651  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
129013057  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
129013294  RAD51B; DNA repair protein RAD51 homolog 2 isoform X4 [KO:K10869]
129013691  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
129014212  BLM; RecQ-like DNA helicase BLM isoform X1 [KO:K10901] [EC:5.6.2.4]
129015544  PALB2; partner and localizer of BRCA2 isoform X2 [KO:K10897]
129016649  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
129017073  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
129017314  BRCA1; breast cancer type 1 susceptibility protein homolog isoform X1 [KO:K10605] [EC:2.3.2.27]
129017392  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
129017708  RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
129018032  TOP3A; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
129018266  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
129018932  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
129020494  POLD1; DNA polymerase delta catalytic subunit isoform X3 [KO:K02327] [EC:2.7.7.7]
129020948  BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776]
129022830  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
129023935  RPA4; replication protein A 30 kDa subunit [KO:K10741]
129024788  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
129030054  BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
129031667  BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
129033913  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X3 [KO:K10728]
129034797  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
129036367  RAD50; DNA repair protein RAD50 isoform X2 [KO:K10866] [EC:3.6.-.-]
129036436  [KO:K11864] [EC:3.4.19.-]
129037398  RAD54L; DNA repair and recombination protein RAD54-like isoform X2 [KO:K10875] [EC:5.6.2.-]
129037452  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
129040013  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 [KO:K03111]
129040341  POLD2; DNA polymerase delta subunit 2 isoform X2 [KO:K02328]
129040566  XRCC2; DNA repair protein XRCC2 [KO:K10879]
129040768  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
129041227  RPA3; replication protein A 14 kDa subunit [KO:K10740]
129042203  NBN; nibrin isoform X1 [KO:K10867]
129042402  RPA2; replication protein A 32 kDa subunit [KO:K10739]
129042522  RAD54B; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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