KEGG   PATHWAY: pspw00260
Entry
pspw00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia sprentiae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pspw00260  Glycine, serine and threonine metabolism
pspw00260

Module
pspw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pspw00260]
pspw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pspw00260]
pspw_M00621  Glycine cleavage system [PATH:pspw00260]
pspw_M00919  Ectoine degradation, ectoine => aspartate [PATH:pspw00260]
pspw_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pspw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia sprentiae [GN:pspw]
Gene
BJG93_03300  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BJG93_21020  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BJG93_05950  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BJG93_20770  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BJG93_05945  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BJG93_18550  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BJG93_29750  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BJG93_10245  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BJG93_26830  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BJG93_21300  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BJG93_10130  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BJG93_28845  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJG93_11655  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJG93_03990  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BJG93_01535  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BJG93_05580  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BJG93_11305  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BJG93_15570  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
BJG93_12440  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJG93_01155  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
BJG93_24160  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
BJG93_05720  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BJG93_10250  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BJG93_21445  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BJG93_21440  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BJG93_13070  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BJG93_13080  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
BJG93_02880  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJG93_06795  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJG93_13075  gcvH; glycine cleavage system protein GcvH [KO:K02437]
BJG93_07930  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BJG93_04750  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
BJG93_26795  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
BJG93_24945  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
BJG93_24950  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
BJG93_26790  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
BJG93_26815  NADH:flavin oxidoreductase [KO:K21833] [EC:1.5.7.3]
BJG93_26810  (Fe-S)-binding protein [KO:K21834]
BJG93_26805  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
BJG93_26800  electron transfer flavoprotein subunit beta/FixA family protein [KO:K25961]
BJG93_26860  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BJG93_26870  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BJG93_26855  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BJG93_26865  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BJG93_16650  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
BJG93_13060  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJG93_26875  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJG93_05650  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
BJG93_10825  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BJG93_22445  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
BJG93_10855  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
BJG93_02840  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
BJG93_20990  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BJG93_21000  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BJG93_22495  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
BJG93_22455  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
BJG93_22470  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
BJG93_22465  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pspw00010  Glycolysis / Gluconeogenesis
pspw00020  Citrate cycle (TCA cycle)
pspw00230  Purine metabolism
pspw00250  Alanine, aspartate and glutamate metabolism
pspw00270  Cysteine and methionine metabolism
pspw00290  Valine, leucine and isoleucine biosynthesis
pspw00300  Lysine biosynthesis
pspw00330  Arginine and proline metabolism
pspw00460  Cyanoamino acid metabolism
pspw00470  D-Amino acid metabolism
pspw00564  Glycerophospholipid metabolism
pspw00620  Pyruvate metabolism
pspw00630  Glyoxylate and dicarboxylate metabolism
pspw00640  Propanoate metabolism
pspw00680  Methane metabolism
pspw00860  Porphyrin metabolism
pspw00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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