KEGG   PATHWAY: psw00260
Entry
psw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas cremoricolorata
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psw00260  Glycine, serine and threonine metabolism
psw00260

Module
psw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psw00260]
psw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psw00260]
psw_M00555  Betaine biosynthesis, choline => betaine [PATH:psw00260]
psw_M00621  Glycine cleavage system [PATH:psw00260]
psw_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:psw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas cremoricolorata [GN:psw]
Gene
LK03_12270  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LK03_20765  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LK03_01055  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LK03_06575  serine kinase [KO:K02204] [EC:2.7.1.39]
LK03_01050  threonine synthase [KO:K01733] [EC:4.2.3.1]
LK03_04105  threonine aldolase [KO:K01620] [EC:4.1.2.48]
LK03_08995  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LK03_04100  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LK03_09460  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
LK03_09810  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
LK03_12970  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
LK03_07300  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
LK03_04920  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LK03_17550  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LK03_11885  MFS transporter [KO:K00831] [EC:2.6.1.52]
LK03_03280  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
LK03_03595  amine oxidase [KO:K00274] [EC:1.4.3.4]
LK03_10285  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LK03_10280  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
LK03_05175  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
LK03_14080  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
LK03_12385  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
LK03_10290  glycine cleavage system protein H [KO:K02437]
LK03_05170  glycine cleavage system protein H [KO:K02437]
LK03_19165  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
LK03_02420  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
LK03_07265  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LK03_07270  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LK03_04125  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
LK03_04120  ferredoxin [KO:K21832] [EC:1.14.13.251]
LK03_04145  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
LK03_04140  (Fe-S)-binding protein [KO:K21834]
LK03_04135  electron transfer flavoprotein subunit alpha [KO:K25960]
LK03_04130  electron transfer flavoprotein subunit beta [KO:K25961]
LK03_04085  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
LK03_04095  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
LK03_04080  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
LK03_04090  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
LK03_12040  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
LK03_19100  serine dehydratase [KO:K01752] [EC:4.3.1.17]
LK03_04200  serine dehydratase [KO:K01752] [EC:4.3.1.17]
LK03_04890  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
LK03_17360  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LK03_06415  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LK03_06420  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LK03_13045  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psw00010  Glycolysis / Gluconeogenesis
psw00020  Citrate cycle (TCA cycle)
psw00230  Purine metabolism
psw00250  Alanine, aspartate and glutamate metabolism
psw00270  Cysteine and methionine metabolism
psw00290  Valine, leucine and isoleucine biosynthesis
psw00300  Lysine biosynthesis
psw00330  Arginine and proline metabolism
psw00460  Cyanoamino acid metabolism
psw00470  D-Amino acid metabolism
psw00564  Glycerophospholipid metabolism
psw00620  Pyruvate metabolism
psw00630  Glyoxylate and dicarboxylate metabolism
psw00640  Propanoate metabolism
psw00680  Methane metabolism
psw00860  Porphyrin metabolism
psw00920  Sulfur metabolism
KO pathway
ko00260   
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