KEGG   PATHWAY: rgor00260
Entry
rgor00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Rhodococcus gordoniae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rgor00260  Glycine, serine and threonine metabolism
rgor00260

Module
rgor_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rgor00260]
rgor_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rgor00260]
rgor_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:rgor00260]
rgor_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:rgor00260]
rgor_M00621  Glycine cleavage system [PATH:rgor00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhodococcus gordoniae [GN:rgor]
Gene
NMQ04_01830  aspartate kinase [KO:K00928] [EC:2.7.2.4]
NMQ04_01835  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NMQ04_07350  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NMQ04_07360  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
NMQ04_07355  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NMQ04_05350  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NMQ04_06300  glycerate kinase [KO:K00865] [EC:2.7.1.165]
NMQ04_16190  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
NMQ04_13575  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NMQ04_04060  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NMQ04_13805  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
NMQ04_11515  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NMQ04_12910  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
NMQ04_16575  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NMQ04_11540  gcvH; glycine cleavage system protein GcvH [KO:K02437]
NMQ04_16710  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
NMQ04_05270  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
NMQ04_13490  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
NMQ04_12525  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
NMQ04_12230  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NMQ04_12235  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
NMQ04_06210  TrpB-like pyridoxal phosphate-dependent enzyme [KO:K06001] [EC:4.2.1.20]
NMQ04_08200  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
NMQ04_08205  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
NMQ04_08195  ectoine synthase [KO:K06720] [EC:4.2.1.108]
NMQ04_03805  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rgor00010  Glycolysis / Gluconeogenesis
rgor00020  Citrate cycle (TCA cycle)
rgor00230  Purine metabolism
rgor00250  Alanine, aspartate and glutamate metabolism
rgor00270  Cysteine and methionine metabolism
rgor00290  Valine, leucine and isoleucine biosynthesis
rgor00300  Lysine biosynthesis
rgor00330  Arginine and proline metabolism
rgor00460  Cyanoamino acid metabolism
rgor00470  D-Amino acid metabolism
rgor00564  Glycerophospholipid metabolism
rgor00620  Pyruvate metabolism
rgor00630  Glyoxylate and dicarboxylate metabolism
rgor00640  Propanoate metabolism
rgor00680  Methane metabolism
rgor00860  Porphyrin metabolism
rgor00920  Sulfur metabolism
KO pathway
ko00260   
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