KEGG   PATHWAY: rn00360
Entry
rn00360                     Pathway                                
Name
Phenylalanine metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
rn00360  Phenylalanine metabolism
rn00360

Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:rn00360]
M00878  Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:rn00360]
Other DBs
GO: 0006558
Reaction
R00228  acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
R00686  L-phenylalanine racemase (ATP-hydrolysing)
R00688  L-phenylalanine:NAD+ oxidoreductase (deaminating)
R00689  L-phenylalanine:oxygen oxidoreductase (deaminating)
R00690  L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)
R00692  L-phenylalanine:pyruvate aminotransferase
R00693  acetyl-CoA:L-phenylalanine N-acetyltransferase
R00694  L-phenylalanine:2-oxoglutarate aminotransferase
R00697  L-phenylalanine ammonia-lyase (trans-cinnamate-forming)
R00698  L-phenylalanine:oxygen oxidoreductase (decarboxylating)
R00699  L-phenylalanine carboxy-lyase (phenylethylamine-forming)
R00750  4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
R00829  succinyl-CoA:acetyl-CoA C-acyltransferase; beta-ketoadipyl-CoA thiolase
R01370  phenyllactate:NAD+ oxidoreductase
R01371  phenyllactate:NADP+ oxidoreductase
R01372  phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
R01374  D-phenylalanine:quinone oxidoreductase (deaminating)
R01377  phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
R01378  phenylpyruvate keto-enol-isomerase
R01582  D-phenylalanine:2-oxoglutarate aminotransferase
R01795  L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
R02252  phenylpropanoate:NAD+ delta2-oxidoreductase
R02254  trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
R02450  phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating)
R02536  phenylacetaldehyde:NAD+ oxidoreductase
R02537  aldehyde:NADP+ oxidoreductase
R02539  phenylacetate:CoA ligase
R02540  2-phenylacetamide amidohydrolase
R02576  phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
R02601  4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
R02603  2-hydroxy-6-oxonona-2,4-diene-1,9-dioate succinylhydrolase
R02611  phenylethylalcohol:NAD+ oxidoreductase
R02612  phenethylamine:(acceptor) oxidoreductase (deaminating)
R02613  phenethylamine:oxygen oxidoreductase (deaminating)
R03369  3-(2-hydroxyphenyl)propanoate,NADH2:oxygen oxidoreductase(3-hydroxylating)
R03709  3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase
R04376  3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)
R04899  
R05001  
R05487  phenylacetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)
R05841  phenylacetyl-CoA:glycine N-phenylacetyltransferase
R06780  
R06781  
R06782  3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
R06783  trans-cinnamate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
R06784  3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
R06785  (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate:NAD+ oxidoreductase
R06786  3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating)
R06787  (2E)-3-(3-hydroxyphenyl)prop-2-enoate,NADH:oxygen oxidoreductase (2-hydroxylating)
R06788  (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate:oxygen 1,2-oxidoreductase (decyclizing)
R06789  (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate fumarylhydrolase
R06790  
R06791  
R06941  (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
R06942  (3S)-3-hydroxyacyl-CoA hydro-lyase
R07222  phenylacetyl-CoA:quinone oxidoreductase
R07294  phenylglyoxylyl-CoA hydrolase
R09820  3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase
R09836  2-oxepin-2(3H)-ylideneacetyl-CoA hydrolyase
R09837  2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
R09838  phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing)
R09839  2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration)
R09840  
R11918  L-phenylalanine carboxy-lyase (oxidative-deaminating)
R13509  3-phenyl-2-oxopropanoate:3-phenyl-2-oxopropanoate ligase (polyporic acid-forming)
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
C23049  Polyporic acid
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00350  Tyrosine metabolism
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00643  Styrene degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
KO pathway
ko00360   

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