KEGG   PATHWAY: rn00380
Entry
rn00380                     Pathway                                
Name
Tryptophan metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
rn00380  Tryptophan metabolism
rn00380

Module
M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:rn00380]
M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:rn00380]
M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin [PATH:rn00380]
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:rn00380]
M00936  Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin [PATH:rn00380]
Other DBs
GO: 0006568 0009851
Reaction
R00074  2-aminophenol:oxygen oxidoreductase (dimerizing)
R00238  acetyl-CoA:acetyl-CoA C-acetyltransferase
R00673  L-tryptophan indole-lyase (deaminating; pyruvate-forming)
R00675  L-tryptophan:NAD+ oxidoreductase (deaminating)
R00677  L-tryptophan:oxygen oxidoreductase (deaminating)
R00678  L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
R00679  L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)
R00681  L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
R00684  L-tryptophan:2-oxoglutarate aminotransferase
R00685  L-tryptophan decarboxy-lyase
R00983  2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing)
R00987  L-kynurenine hydrolase
R00988  N-formylanthranilate amidohydrolase
R00991  
R01814  L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
R01933  2-oxoadipate dehydrogenase complex
R01937  
R01938  
R01956  L-kynurenine:2-oxoglutarate aminotransferase
R01959  N-formyl-L-kynurenine amidohydrolase
R01960  L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
R01973  S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase
R01974  3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
R01975  (S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase
R02173  tryptamine:oxygen oxidoreductase(deaminating)
R02174  S-adenosyl-L-methionine:amine N-methyltransferase
R02338  indole:oxygen 2,3-oxidoreductase (decyclizing)
R02339  
R02488  glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
R02665  3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
R02668  3-hydroxy-L-kynurenine hydrolase
R02669  
R02670  
R02671  
R02678  indole-3-acetaldehyde:NAD+ oxidoreductase
R02679  indole-3-ethanol:NAD+ oxidoreductase
R02680  indole-3-ethanol:NADP+ oxidoreductase
R02681  indole-3-acetaldehyde:oxygen oxidoreductase
R02700  5-hydroxy-L-tryptophan:2-oxoglutarate aminotransferase
R02701  5-hydroxy-L-tryptophan decarboxy-lyase
R02702  5-hydroxy-L-tryptophan:oxygen 2,3-dioxygenase (indole-decyclizing)
R02908  5-hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)
R02909  5-hydroxytryptamine:oxygen 2,3-dioxygenase (indole-decyclizing)
R02910  S-adenosyl-L-methionine:amine N-methyltransferase
R02911  acetyl-CoA:aralkylamine N-acetyltransferase
R02912  serotonin O-methyltransferase
R03026  (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03092  
R03093  3-indoleacetonitrile aminohydrolase
R03096  indole-3-acetamide amidohydrolase
R03097  
R03130  S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase
R03251  7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase
R03253  7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)
R03439  kynurenate:oxygen oxidoreductase (hydroxylating)
R03440  kynurenate:oxygen oxidoreductase (hydroxylating)
R03445  
R03628  melatonin:oxygen 2,3-dioxygenase (indole-decyclizing)
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R03873  N-acetylindoxyl:oxygen oxidoreductase
R03887  2-aminomuconate aminohydrolase
R03889  2-aminomuconate semialdehyde:NAD+ 6-oxidoreductase
R03911  
R03936  formylkynurenine hydrolase
R03954  
R03955  
R04020  indole-3-acetamide hydro-lyase
R04093  3-indoleacetaldoxime hydro-lyase
R04094  thioglucoside glucohydrolase
R04171  3-hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
R04172  
R04293  
R04323  2-amino-3-carboxymuconate semialdehyde carboxy-lyase
R04903  5-hydroxyindoleacetaldehyde:NAD+ oxidoreductase
R04904  5-hydroxyindoleacetaldehyde:oxygen oxidoreductase
R04905  S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
R04906  
R04907  3-hydroxykynurenamine:oxygen oxidoreductase(deaminating)(flavin-containing)
R04908  5-hydroxykynurenamine:oxygen oxidoreductase(deaminating)(flavin-containing)
R04909  5-hydroxykynurenamine decarboxy-lyase
R04910  
R04911  aryl-formylamine amidohydrolase
R04913  5-hydroxykynurenine:2-oxoglutarate aminotransferase
R04914  
R04916  
R04917  
R04918  
R08160  L-tryptophan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
R08164  UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase
R08167  3'-phosphoadenylyl-sulfate:indolylmethyl-desulfoglucosinolate sulfotransferase
R08168  indole-3-acetaldehyde-oxime,NADPH:oxidoreductase
R08170  
R08604  tryptamine,NADPH:oxygen oxidoreductase (N-hydroxylating)
R08605  N-hydroxyl-tryptamine oxidoreductase
R08606  
R08609  
R09517  anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)
R10180  L-tryptophan:pyruvate aminotransferase
R10181  indole-3-pyruvate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R11022  
R12055  L-methionine:indole-3-pyruvic acid aminotransferase
R12256  (R)-(indol-3-yl)lactate:NAD+ oxidoreductase
R12303  (1H-indol-3-yl)acetate carboxy-lyase (skatole-forming)
R12501  
R12659  tryptamine,NADPH---hemoprotein reductase:oxygen oxidoreductase (5-hydroxylating)
R13526  (indol-3-yl)pyruvate:(indol-3-yl)pyruvate ligase (didemethylasterriquinone D-forming)
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
C23064  Didemethylasterriquinone D
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00627  Aminobenzoate degradation
rn00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   

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