KEGG   PATHWAY: rn00760
Entry
rn00760                     Pathway                                
Name
Nicotinate and nicotinamide metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00760  Nicotinate and nicotinamide metabolism
rn00760

Module
M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:rn00760]
M00622  Nicotinate degradation, nicotinate => fumarate [PATH:rn00760]
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde [PATH:rn00760]
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde [PATH:rn00760]
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:rn00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Reaction
R00102  NAD+ glycohydrolase
R00103  NAD+ phosphohydrolase
R00104  ATP:NAD+ 2'-phosphotransferase
R00112  NADPH:NAD+ oxidoreductase
R00118  NADP+ 2'-phosphohydrolase
R00119  NADP+:nicotinate ADP-ribosyltransferase
R00137  ATP:nicotinamide-nucleotide adenylyltransferase
R00189  deamido-NAD+:ammonia ligase (AMP-forming)
R00257  deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
R00481  L-aspartate:oxygen oxidoreductase
R00713  succinate-semialdehyde:NAD+ oxidoreductase
R00714  succinate-semialdehyde:NADP+ oxidoreductase
R01087  maleate cis-trans-isomerase
R01268  nicotinamide amidohydrolase
R01269  S-adenosyl-L-methionine:nicotinamide N-methyltransferase
R01270  nicotinamide D-ribonucleotide phosphoribohydrolase
R01271  nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
R01273  N-ribosylnicotinamide ribohydrolase
R01355  2,3-dimethylmalate pyruvate-lyase
R01720  nicotinate:NADP+ 6-oxidoreductase (hydroxylating)
R01723   
R01724  5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)
R02294  N-ribosylnicotinamide:orthophosphate ribosyltransferase
R02295  nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
R02322  nicotinamide-D-ribonucleotide amidohydrolase
R02323  nicotinamide ribonucleotide phosphohydrolase
R02324  ATP:N-ribosylnicotinamide 5'-phosphotransferase
R02860  nicotine:acceptor 6-oxidoreductase (hydroxylating)
R02861   
R03004  deamino-NAD+ nucleotidohydrolase
R03005  ATP:nicotinamide-nucleotide adenylyltransferase
R03069  (2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)
R03070  methylitaconate Delta2-Delta3-isomerase
R03164  1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
R03346  nicotinate D-ribonucleotide phosphohydrolase
R03347  ATP:beta-D-ribosylnicotinate 5-phosphotransferase
R03348  nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)
R03540  maleamate amidohydrolase
R03908  2-methyleneglutarate carboxy-methylenemethylmutase
R04085  aldehyde:oxygen oxidoreductase
R04130  2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
R04292  glycerone phosphate:iminosuccinate alkyltransferase (cyclizing)
R07221  6-hydroxynicotinate:O2 oxidoreductase
R07407  L-aspartate:NADP+ oxidoreductase (deaminating)
R07410  L-aspartate:NAD+ oxidoreductase (deaminating)
R07514  6-hydroxypseudooxynicotinemonooxygenase
R07515  2,6-dihydroxypseudooxynicotine hydrolase
R07946   
R07947   
R07948   
R07949   
R07983   
R07984  6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase
R07985  (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
R07986   
R08408  aldehyde:oxygen oxidoreductase
R08764  6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
R09125  2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
R09126  N-formylmaleamic acid amidohydrolase
R09471   
R09472  4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
R09473  nicotinate:cytochrome 6-oxidoreductase (hydroxylating)
R10046  nicotinate D-ribonucleoside ribohydrolase
R10101  4-methylaminobutanoate methylamidohydrolase
R10102  4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
R10103  4-(methylamino)-1-(pyridin-3-yl)butan-1-one:c-type cytochrome oxidoreductase (methylamine releasing)
R10105  4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
R10131  3,3'-bipyridine-2,2',5,5',6,6'-hexol:NAD+ 11-oxidoreductase
R10132  3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP+ 11-oxidoreductase
R10633   
R10634   
R11048   
R11049   
R11050   
R11175  (S)-nicotine:cytochrome c oxidoreductase (N-methylmimosine-forming)
R11176   
R11178   
R11179   
R13176  NADPH:NAD+ oxidoreductase (H+-transporting)
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00250  Alanine, aspartate and glutamate metabolism
rn00380  Tryptophan metabolism
rn00620  Pyruvate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
KO pathway
ko00760   
LinkDB

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