KEGG   PATHWAY: ko00380
Entry
ko00380                     Pathway                                
Name
Tryptophan metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
ko00380  Tryptophan metabolism
ko00380

Module
M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:ko00380]
M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:ko00380]
M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin [PATH:ko00380]
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:ko00380]
M00936  Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin [PATH:ko00380]
Other DBs
GO: 0006568 0009851
Orthology
K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00128  ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
K00252  GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
K00382  DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00452  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6]
K00453  TDO2, kynA; tryptophan 2,3-dioxygenase [EC:1.13.11.11]
K00463  IDO, INDO; indoleamine 2,3-dioxygenase [EC:1.13.11.52]
K00466  iaaM; tryptophan 2-monooxygenase [EC:1.13.12.3]
K00486  KMO; kynurenine 3-monooxygenase [EC:1.14.13.9]
K00502  TPH1_2; tryptophan 5-monooxygenase [EC:1.14.16.4]
K00543  ASMT; acetylserotonin O-methyltransferase [EC:2.1.1.4]
K00562  INMT, TEMT; methyltransferase [EC:2.1.1.49 2.1.1.96]
K00626  ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00658  DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K00669  AANAT; arylalkylamine N-acetyltransferase [EC:2.3.1.87]
K00816  CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
K00825  AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]
K00837  ISS1, VAS1; aromatic aminotransferase
K00838  ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K01237  E3.2.1.147; myrosinase [EC:3.2.1.147]
K01426  E3.5.1.4, amiE; amidase [EC:3.5.1.4]
K01432  AFMID; arylformamidase [EC:3.5.1.9]
K01501  E3.5.5.1; nitrilase [EC:3.5.5.1]
K01556  KYNU; kynureninase [EC:3.7.1.3]
K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K01667  tnaA; tryptophanase [EC:4.1.99.1]
K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
K01721  nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]
K01782  fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K03334  IL4I1; L-amino-acid oxidase [EC:1.4.3.2]
K03392  ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]
K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
K03782  katG; catalase-peroxidase [EC:1.11.1.21]
K04103  ipdC; indolepyruvate decarboxylase [EC:4.1.1.74]
K07130  kynB; arylformamidase [EC:3.5.1.9]
K07408  CYP1A1; cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  CYP1A2; cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07410  CYP1B1; cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10217  dmpC, xylG, praB; aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85]
K11182  AOC1, ABP1; diamine oxidase [EC:1.4.3.22]
K11812  CYP79B1_2; tryptophan N-monooxygenase [EC:1.14.14.156]
K11813  CYP79B3; tryptophan N-monooxygenase [EC:1.14.14.156]
K11816  YUCCA; indole-3-pyruvate monooxygenase [EC:1.14.13.168]
K11817  AAO1_2; indole-3-acetaldehyde oxidase [EC:1.2.3.7]
K11818  CYP83B1; aromatic aldoxime N-monooxygenase [EC:1.14.14.45]
K11819  SUR1, RTY; S-alkyl-thiohydroximate lyase SUR1 [EC:4.4.1.-]
K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195]
K11821  ST5A, SOT16; aromatic desulfoglucosinolate sulfotransferase [EC:2.8.2.24]
K11868  CYP71A13; indoleacetaldoxime dehydratase [EC:4.8.1.3]
K13066  COMT; caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase [EC:2.1.1.68 2.1.1.4]
K14085  ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K14263  BNA7; kynurenine formamidase [EC:3.5.1.9]
K14264  BNA3; kynurenine aminotransferase [EC:2.6.1.7]
K14265  Tam1; tryptophan aminotransferase [EC:2.6.1.27]
K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
K15067  amnD; 2-aminomuconate deaminase [EC:3.5.99.5]
K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K16902  E1.5.1.45; FAD reductase [NAD(P)H] [EC:1.5.1.45]
K16903  TAA1; L-tryptophan---pyruvate aminotransferase [EC:2.6.1.99]
K20204  griF; grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4]
K20219  phsA; o-aminophenol oxidase [EC:1.10.3.4]
K20807  nthB; nitrile hydratase subunit beta [EC:4.2.1.84]
K21801  iaaH; indoleacetamide hydrolase [EC:3.5.1.-]
K22417  AAO4; benzaldehyde dehydrogenase (NAD+) / indole-3-acetaldehyde oxidase [EC:1.2.1.28 1.2.3.7]
K22433  PSID; L-tryptophan decarboxylase [EC:4.1.1.105]
K22450  SNAT; aralkylamine N-acetyltransferase [EC:2.3.1.87]
K22588  ASMT; acetylserotonin O-methyltransferase, plant [EC:2.1.1.4]
K23109  fldH; aromatic 2-oxoacid reductase
K23234  ALDH8A1; aminomuconate-semialdehyde dehydrogenase
K23384  iad; indoleacetate decarboxylase
K23947  DAO; 2-oxoglutarate-dependent dioxygenase
K24541  CYP71P1; tryptamine 5-hydroxylase
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00362  Benzoate degradation
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00627  Aminobenzoate degradation
ko00760  Nicotinate and nicotinamide metabolism

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