KEGG   PATHWAY: same00260
Entry
same00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sinorhizobium americanum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
same00260  Glycine, serine and threonine metabolism
same00260

Module
same_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:same00260]
same_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:same00260]
same_M00555  Betaine biosynthesis, choline => betaine [PATH:same00260]
same_M00621  Glycine cleavage system [PATH:same00260]
same_M00919  Ectoine degradation, ectoine => aspartate [PATH:same00260]
same_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:same00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sinorhizobium americanum [GN:same]
Gene
SAMCFNEI73_Ch0030  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SAMCFNEI73_Ch0031  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SAMCFNEI73_Ch0202  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SAMCFNEI73_Ch0212  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMCFNEI73_Ch0913  antA; anthranilate 1,2-dioxygenase large subunit [KO:K00479] [EC:1.14.13.251]
SAMCFNEI73_Ch0914  hcr; NADH oxidoreductase Hcr [KO:K21832] [EC:1.14.13.251]
SAMCFNEI73_Ch0966  thrB; homoserine kinase ThrB [KO:K02204] [EC:2.7.1.39]
SAMCFNEI73_Ch0974  thrC; threonine synthase ThrC [KO:K01733] [EC:4.2.3.1]
SAMCFNEI73_Ch1007  betA; choline dehydrogenase BetA [KO:K00108] [EC:1.1.99.1]
SAMCFNEI73_Ch1009  betB; betaine aldehyde dehydrogenase BetB [KO:K00130] [EC:1.2.1.8]
SAMCFNEI73_Ch1187  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
SAMCFNEI73_Ch1277  glyA; pyridoxal-phosphate-dependent serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAMCFNEI73_Ch1536  sdaA; L-serine dehydratase SdaA [KO:K01752] [EC:4.3.1.17]
SAMCFNEI73_Ch1579  lpdA; dihydrolipoyl dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
SAMCFNEI73_Ch1691  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SAMCFNEI73_Ch1732  gpmB; phosphoglycerate kinase [KO:K15634] [EC:5.4.2.11]
SAMCFNEI73_Ch1774  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
SAMCFNEI73_Ch1933  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SAMCFNEI73_Ch1934  gcvH; glycine cleavage system H protein GcvH [KO:K02437]
SAMCFNEI73_Ch1935  gcvT; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
SAMCFNEI73_Ch2397  [KO:K01079] [EC:3.1.3.3]
SAMCFNEI73_Ch2544  [KO:K00315] [EC:1.5.8.4]
SAMCFNEI73_Ch2609  tdh; L-threonine 3-dehydrogenase Tdh [KO:K00060] [EC:1.1.1.103]
SAMCFNEI73_Ch2610  kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
SAMCFNEI73_Ch2983  lysC; aspartokinase LysC [KO:K00928] [EC:2.7.2.4]
SAMCFNEI73_Ch3138  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAMCFNEI73_Ch3139  serC; phosphoserine aminotransferase SerC [KO:K00831] [EC:2.6.1.52]
SAMCFNEI73_Ch3245  ltaE; low specificity L-threonine aldolase LtaE [KO:K01620] [EC:4.1.2.48]
SAMCFNEI73_Ch3276  soxG; sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
SAMCFNEI73_Ch3277  soxA; sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
SAMCFNEI73_Ch3278  soxD; sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
SAMCFNEI73_Ch3279  soxB; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
SAMCFNEI73_Ch3365  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMCFNEI73_Ch3434  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
SAMCFNEI73_Ch3492  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMCFNEI73_Ch3692  ttuD; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
SAMCFNEI73_Ch3701  asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]
SAMCFNEI73_Ch3714  ectC; L-ectoine synthase EctC [KO:K06720] [EC:4.2.1.108]
SAMCFNEI73_pB0208  kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
SAMCFNEI73_pB0212  [KO:K15783] [EC:3.5.4.44]
SAMCFNEI73_pB0218  [KO:K15783] [EC:3.5.4.44]
SAMCFNEI73_pB0376  prr; gamma-aminobutyrate:alpha-ketoglutarate aminotransferase [KO:K15785] [EC:2.6.1.76]
SAMCFNEI73_pC0235  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMCFNEI73_pC0252  [KO:K01697] [EC:4.2.1.22]
SAMCFNEI73_pC0337  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMCFNEI73_pC0355  [KO:K11529] [EC:2.7.1.165]
SAMCFNEI73_pC0603  ttuD; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
SAMCFNEI73_pC0649  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SAMCFNEI73_pC0655  sgaA; serine--glyoxylate aminotransferase SgaA [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SAMCFNEI73_pC0663  [KO:K01620] [EC:4.1.2.48]
SAMCFNEI73_pC0887  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
SAMCFNEI73_pC1168  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAMCFNEI73_pC1584  [KO:K01754] [EC:4.3.1.19]
SAMCFNEI73_pC1613  lpdA; dihydrolipoyl dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
SAMCFNEI73_pC1834  [KO:K15784] [EC:3.5.1.125]
SAMCFNEI73_pC1835  [KO:K15783] [EC:3.5.4.44]
SAMCFNEI73_pC1837  [KO:K01754] [EC:4.3.1.19]
SAMCFNEI73_pC1846  gabD; succinate-semialdehyde dehydrogenase [NADP+] [KO:K15786] [EC:1.2.1.-]
SAMCFNEI73_pC1847  [KO:K15785] [EC:2.6.1.76]
SAMCFNEI73_pC1952  gbsA; betaine aldehyde dehydrogenase GbsA [KO:K00130] [EC:1.2.1.8]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
same00010  Glycolysis / Gluconeogenesis
same00020  Citrate cycle (TCA cycle)
same00230  Purine metabolism
same00250  Alanine, aspartate and glutamate metabolism
same00270  Cysteine and methionine metabolism
same00290  Valine, leucine and isoleucine biosynthesis
same00300  Lysine biosynthesis
same00330  Arginine and proline metabolism
same00460  Cyanoamino acid metabolism
same00470  D-Amino acid metabolism
same00564  Glycerophospholipid metabolism
same00600  Sphingolipid metabolism
same00620  Pyruvate metabolism
same00630  Glyoxylate and dicarboxylate metabolism
same00640  Propanoate metabolism
same00680  Methane metabolism
same00860  Porphyrin metabolism
same00920  Sulfur metabolism
KO pathway
ko00260   

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