KEGG   PATHWAY: sce03430
sce03430                    Pathway                                
Mismatch repair - Saccharomyces cerevisiae (budding yeast)
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
sce03430  Mismatch repair

Other DBs
GO: 0006298
Saccharomyces cerevisiae (budding yeast) [GN:sce]
YJL092W  SRS2; DNA helicase SRS2 [KO:K03657] [EC:]
YNL082W  PMS1; ATP-binding mismatch repair protein [KO:K10858]
YMR167W  MLH1; mismatch repair ATPase MLH1 [KO:K08734]
YDR097C  MSH6; mismatch repair ATPase MSH6 [KO:K08737]
YOL090W  MSH2; mismatch repair ATPase MSH2 [KO:K08735]
YCR092C  MSH3; mismatch repair protein MSH3 [KO:K08736]
YPL164C  MLH3; mismatch repair protein MLH3 [KO:K08739]
YOR217W  RFC1; replication factor C subunit 1 [KO:K10754]
YJR068W  RFC2; replication factor C subunit 2 [KO:K10755]
YOL094C  RFC4; replication factor C subunit 4 [KO:K10755]
YNL290W  RFC3; replication factor C subunit 3 [KO:K10756]
YBR087W  RFC5; replication factor C subunit 5 [KO:K10756]
YBR088C  POL30; proliferating cell nuclear antigen [KO:K04802]
YOR033C  EXO1; Rad2 family nuclease EXO1 [KO:K10746] [EC:3.1.-.-]
YAR007C  RFA1; replication factor A subunit protein RFA1 [KO:K07466]
YNL312W  RFA2; Rfa2p [KO:K10739]
YDL102W  POL3; DNA-directed DNA polymerase delta POL3 [KO:K02327] [EC:]
YJR006W  POL31; DNA-directed DNA polymerase delta subunit POL31 [KO:K02328]
YJR043C  POL32; DNA polymerase delta subunit POL32 [KO:K03504]
YDL164C  CDC9; DNA ligase (ATP) CDC9 [KO:K10747] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair]
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

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