KEGG   PATHWAY: scm03015
Entry
scm03015                    Pathway                                
Name
mRNA surveillance pathway - Schizophyllum commune
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
scm03015  mRNA surveillance pathway
scm03015

Other DBs
GO: 0071028
Organism
Schizophyllum commune [GN:scm]
Gene
SCHCO_01165873  SCHCODRAFT_01165873; Poly(A) polymerase [KO:K14376] [EC:2.7.7.19]
SCHCO_012799  SCHCODRAFT_012799; Ssu72-like protein [KO:K15544] [EC:3.1.3.16]
SCHCO_01340209  SCHCODRAFT_01340209; serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
SCHCO_02005419  SCHCODRAFT_02005419; uncharacterized protein [KO:K03265]
SCHCO_02017472  SCHCODRAFT_02017472; uncharacterized protein [KO:K14404]
SCHCO_02301738  SCHCODRAFT_02301738; WD40 repeat-like protein [KO:K14962]
SCHCO_02318824  SCHCODRAFT_02318824; polyadenylate binding protein [KO:K13126]
SCHCO_02484365  SCHCODRAFT_02484365; uncharacterized protein [KO:K14399] [EC:2.7.1.78]
SCHCO_02494378  SCHCODRAFT_02494378; protein phosphatase 2A regulatory subunit PR55 [KO:K04354]
SCHCO_02500640  SCHCODRAFT_02500640; uncharacterized protein [KO:K14401]
SCHCO_02506351  SCHCODRAFT_02506351; uncharacterized protein [KO:K14328]
SCHCO_02516538  SCHCODRAFT_02516538; uncharacterized protein [KO:K13126]
SCHCO_02521778  SCHCODRAFT_02521778; Suf-domain-containing protein [KO:K14408]
SCHCO_02543025  SCHCODRAFT_02543025; protein phosphatase 2A [KO:K04382] [EC:3.1.3.16]
SCHCO_0255173  SCHCODRAFT_0255173; uncharacterized protein [KO:K14325]
SCHCO_02566622  SCHCODRAFT_02566622; uncharacterized protein [KO:K14400]
SCHCO_02604934  SCHCODRAFT_02604934; uncharacterized protein [KO:K13126]
SCHCO_02605926  SCHCODRAFT_02605926; protein phosphatase 2A regulatory B subunit [KO:K11584]
SCHCO_02606234  SCHCODRAFT_02606234; RNA-binding domain-containing protein [KO:K12883]
SCHCO_02606534  SCHCODRAFT_02606534; uncharacterized protein [KO:K00565] [EC:2.1.1.56]
SCHCO_02606648  SCHCODRAFT_02606648; uncharacterized protein [KO:K11124] [EC:3.1.-.-]
SCHCO_02610305  SCHCODRAFT_02610305; uncharacterized protein [KO:K14407]
SCHCO_02611036  SCHCODRAFT_02611036; NTF2-like protein [KO:K14285]
SCHCO_02611527  SCHCODRAFT_02611527; phosphoprotein phosphatase PPZ [KO:K06269] [EC:3.1.3.16]
SCHCO_02611649  SCHCODRAFT_02611649; ARM repeat-containing protein [KO:K03456]
SCHCO_02613522  SCHCODRAFT_02613522; Fip1-domain-containing protein [KO:K14405]
SCHCO_02617748  SCHCODRAFT_02617748; uncharacterized protein [KO:K06100]
SCHCO_02618639  SCHCODRAFT_02618639; RNA-binding domain-containing protein [KO:K12876]
SCHCO_02621700  SCHCODRAFT_02621700; uncharacterized protein [KO:K03267]
SCHCO_02621814  SCHCODRAFT_02621814; uncharacterized protein [KO:K06965]
SCHCO_02623046  SCHCODRAFT_02623046; uncharacterized protein [KO:K14402]
SCHCO_02623214  SCHCODRAFT_02623214; DEAD-domain-containing protein [KO:K13025] [EC:5.6.2.7]
SCHCO_02624203  SCHCODRAFT_02624203; uncharacterized protein [KO:K14416]
SCHCO_02626448  SCHCODRAFT_02626448; Poly(A) polymerase [KO:K14376] [EC:2.7.7.19]
SCHCO_02627251  SCHCODRAFT_02627251; NTF2-like protein [KO:K14284]
SCHCO_02629417  SCHCODRAFT_02629417; cleavage and polyadenylation specificity factor, 25 kDa subunit [KO:K14397]
SCHCO_02640902  SCHCODRAFT_02640902; uncharacterized protein [KO:K12881]
SCHCO_02641156  SCHCODRAFT_02641156; uncharacterized protein [KO:K12881]
SCHCO_02642174  SCHCODRAFT_02642174; uncharacterized protein [KO:K18723]
SCHCO_02645961  SCHCODRAFT_02645961; uncharacterized protein [KO:K12882]
SCHCO_02663071  SCHCODRAFT_02663071; uncharacterized protein [KO:K14404]
SCHCO_02678789  SCHCODRAFT_02678789; uncharacterized protein [KO:K14407]
SCHCO_02688704  SCHCODRAFT_02688704; Mago nashi protein [KO:K12877]
SCHCO_02691379  SCHCODRAFT_02691379; Metallo-hydrolase/oxidoreductase [KO:K14403] [EC:3.1.27.-]
SCHCO_02701711  SCHCODRAFT_02701711; P-loop containing nucleoside triphosphate hydrolase protein [KO:K18655] [EC:5.6.2.7]
SCHCO_02743816  SCHCODRAFT_02743816; P-loop containing nucleoside triphosphate hydrolase protein [KO:K12812] [EC:5.6.2.7]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
scm03013  Nucleocytoplasmic transport
scm03018  RNA degradation
scm03040  Spliceosome
KO pathway
ko03015   

DBGET integrated database retrieval system