KEGG   PATHWAY: sdur00230
Entry
sdur00230                   Pathway                                
Name
Purine metabolism - Streptomyces durmitorensis
Class
Metabolism; Nucleotide metabolism
Pathway map
sdur00230  Purine metabolism
sdur00230

Module
sdur_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sdur00230]
sdur_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sdur00230]
sdur_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sdur00230]
sdur_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sdur00230]
sdur_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sdur00230]
sdur_M00546  Purine degradation, xanthine => urea [PATH:sdur00230]
sdur_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:sdur00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces durmitorensis [GN:sdur]
Gene
M4V62_24915  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
M4V62_22540  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
M4V62_22430  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
M4V62_17810  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
M4V62_22500  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
M4V62_22490  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
M4V62_22495  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
M4V62_22545  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
M4V62_25335  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
M4V62_25340  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
M4V62_22445  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
M4V62_35980  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
M4V62_17805  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
M4V62_34530  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
M4V62_22930  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
M4V62_26600  HAD-IIA family hydrolase [KO:K02566] [EC:3.1.3.5]
M4V62_17130  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
M4V62_30700  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
M4V62_20020  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
M4V62_18030  GuaB3 family IMP dehydrogenase-related protein [KO:K00088] [EC:1.1.1.205]
M4V62_18035  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
M4V62_27745  ndk; nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
M4V62_26350  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
M4V62_39410  FAD binding domain-containing protein [KO:K13481] [EC:1.17.1.4]
M4V62_39415  xdhB; xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
M4V62_41350  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
M4V62_02325  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
M4V62_41345  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
M4V62_02320  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
M4V62_41340  2Fe-2S iron-sulfur cluster-binding protein [KO:K13483]
M4V62_02315  2Fe-2S iron-sulfur cluster-binding protein [KO:K13483]
M4V62_02875  type 1 glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
M4V62_17955  guaA; glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
M4V62_34775  GuaB1 family IMP dehydrogenase-related protein [KO:K26110] [EC:1.7.1.7]
M4V62_34700  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
M4V62_12405  vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
M4V62_15460  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
M4V62_15465  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
M4V62_28550  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
M4V62_12465  HD domain-containing protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
M4V62_34535  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
M4V62_19720  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
M4V62_25085  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
M4V62_17075  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
M4V62_20715  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
M4V62_10120  PfkB family carbohydrate kinase [KO:K00856] [EC:2.7.1.20]
M4V62_30290  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
M4V62_17225  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
M4V62_18445  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
M4V62_42300  amidohydrolase family protein [KO:K01486] [EC:3.5.4.2]
M4V62_28065  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
M4V62_31120  5'-nucleotidase C-terminal domain-containing protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
M4V62_18240  adenylate kinase [KO:K00939] [EC:2.7.4.3]
M4V62_41450  metallophosphoesterase [KO:K03651] [EC:3.1.4.53]
M4V62_25170  phosphodiesterase [KO:K03651] [EC:3.1.4.53]
M4V62_34450  HIT domain-containing protein [KO:K19710] [EC:2.7.7.53]
M4V62_10780  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
M4V62_10790  GTP-binding protein [KO:K00956] [EC:2.7.7.4]
M4V62_10785  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
M4V62_10215  pucL; urate oxidase [KO:K00365] [EC:1.7.3.3]
M4V62_10220  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
M4V62_10225  uraD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
M4V62_17455  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
M4V62_31310  aspartate/glutamate racemase family protein [KO:K16841] [EC:5.1.99.3]
M4V62_09885  allB; allantoinase AllB [KO:K01466] [EC:3.5.2.5]
M4V62_09880  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
M4V62_04800  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
M4V62_13800  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
M4V62_04805  urease subunit beta [KO:K01429] [EC:3.5.1.5]
M4V62_04810  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
M4V62_13805  ureA; urease subunit gamma [KO:K14048] [EC:3.5.1.5]
M4V62_37190  carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
sdur00030  Pentose phosphate pathway
sdur00220  Arginine biosynthesis
sdur00250  Alanine, aspartate and glutamate metabolism
sdur00260  Glycine, serine and threonine metabolism
sdur00340  Histidine metabolism
sdur00630  Glyoxylate and dicarboxylate metabolism
sdur00730  Thiamine metabolism
sdur00740  Riboflavin metabolism
sdur00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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