KEGG   PATHWAY: sdur00260
Entry
sdur00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces durmitorensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sdur00260  Glycine, serine and threonine metabolism
sdur00260

Module
sdur_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sdur00260]
sdur_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sdur00260]
sdur_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sdur00260]
sdur_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sdur00260]
sdur_M00555  Betaine biosynthesis, choline => betaine [PATH:sdur00260]
sdur_M00621  Glycine cleavage system [PATH:sdur00260]
sdur_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:sdur00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces durmitorensis [GN:sdur]
Gene
M4V62_20615  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M4V62_20610  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M4V62_27515  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M4V62_14945  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
M4V62_14935  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
M4V62_42940  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
M4V62_14940  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
M4V62_16260  threonine synthase [KO:K01733] [EC:4.2.3.1]
M4V62_23485  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
M4V62_36720  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
M4V62_38240  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M4V62_14180  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M4V62_14895  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M4V62_17620  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M4V62_41365  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
M4V62_09230  glycerate kinase [KO:K00865] [EC:2.7.1.165]
M4V62_30355  glycerate kinase [KO:K00865] [EC:2.7.1.165]
M4V62_23215  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
M4V62_37955  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M4V62_13925  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M4V62_23865  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
M4V62_21810  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
M4V62_32475  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
M4V62_07470  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
M4V62_07475  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
M4V62_10915  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
M4V62_35290  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
M4V62_14170  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
M4V62_03855  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M4V62_30170  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M4V62_14175  gcvH; glycine cleavage system protein GcvH [KO:K02437]
M4V62_07745  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
M4V62_09195  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
M4V62_37090  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
M4V62_37100  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
M4V62_13055  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
M4V62_13205  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
M4V62_17710  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
M4V62_41085  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
M4V62_41090  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
M4V62_35110  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
M4V62_38255  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
M4V62_38245  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
M4V62_38260  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
M4V62_38250  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
M4V62_25160  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
M4V62_21830  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
M4V62_14185  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
M4V62_16900  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
M4V62_25270  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
M4V62_30945  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
M4V62_30940  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
M4V62_12440  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
M4V62_32120  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
M4V62_32125  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
M4V62_32115  ectoine synthase [KO:K06720] [EC:4.2.1.108]
M4V62_32110  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
M4V62_26980  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sdur00010  Glycolysis / Gluconeogenesis
sdur00020  Citrate cycle (TCA cycle)
sdur00230  Purine metabolism
sdur00250  Alanine, aspartate and glutamate metabolism
sdur00270  Cysteine and methionine metabolism
sdur00290  Valine, leucine and isoleucine biosynthesis
sdur00300  Lysine biosynthesis
sdur00330  Arginine and proline metabolism
sdur00460  Cyanoamino acid metabolism
sdur00470  D-Amino acid metabolism
sdur00564  Glycerophospholipid metabolism
sdur00600  Sphingolipid metabolism
sdur00620  Pyruvate metabolism
sdur00630  Glyoxylate and dicarboxylate metabolism
sdur00640  Propanoate metabolism
sdur00680  Methane metabolism
sdur00860  Porphyrin metabolism
sdur00920  Sulfur metabolism
KO pathway
ko00260   
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