KEGG   PATHWAY: sfug00260
Entry
sfug00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces fungicidicus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sfug00260  Glycine, serine and threonine metabolism
sfug00260

Module
sfug_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfug00260]
sfug_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sfug00260]
sfug_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sfug00260]
sfug_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sfug00260]
sfug_M00621  Glycine cleavage system [PATH:sfug00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces fungicidicus [GN:sfug]
Gene
CNQ36_18795  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CNQ36_12040  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CNQ36_18800  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CNQ36_24380  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CNQ36_24390  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CNQ36_15590  threonine synthase [KO:K01733] [EC:4.2.3.1]
CNQ36_24385  threonine synthase [KO:K01733] [EC:4.2.3.1]
CNQ36_04285  threonine aldolase [KO:K01620] [EC:4.1.2.48]
CNQ36_21790  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CNQ36_24430  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CNQ36_25030  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CNQ36_27140  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CNQ36_15795  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
CNQ36_27795  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CNQ36_15305  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CNQ36_07725  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CNQ36_31110  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
CNQ36_31105  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
CNQ36_05435  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CNQ36_25040  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CNQ36_09725  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CNQ36_25035  gcvH; glycine cleavage system protein H [KO:K02437]
CNQ36_30900  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
CNQ36_27150  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CNQ36_21740  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CNQ36_28335  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CNQ36_28370  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CNQ36_29935  N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
CNQ36_14065  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CNQ36_17270  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
CNQ36_25025  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CNQ36_32035  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CNQ36_22330  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CNQ36_09010  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CNQ36_09015  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CNQ36_08060  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CNQ36_08055  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
CNQ36_08065  ectC; ectoine synthase [KO:K06720] [EC:4.2.1.108]
CNQ36_08070  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
CNQ36_12655  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sfug00010  Glycolysis / Gluconeogenesis
sfug00020  Citrate cycle (TCA cycle)
sfug00230  Purine metabolism
sfug00250  Alanine, aspartate and glutamate metabolism
sfug00270  Cysteine and methionine metabolism
sfug00290  Valine, leucine and isoleucine biosynthesis
sfug00300  Lysine biosynthesis
sfug00330  Arginine and proline metabolism
sfug00460  Cyanoamino acid metabolism
sfug00470  D-Amino acid metabolism
sfug00564  Glycerophospholipid metabolism
sfug00600  Sphingolipid metabolism
sfug00620  Pyruvate metabolism
sfug00630  Glyoxylate and dicarboxylate metabolism
sfug00640  Propanoate metabolism
sfug00680  Methane metabolism
sfug00860  Porphyrin metabolism
sfug00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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