KEGG   PATHWAY: sgz00260
Entry
sgz00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces globosus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sgz00260  Glycine, serine and threonine metabolism
sgz00260

Module
sgz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sgz00260]
sgz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sgz00260]
sgz_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sgz00260]
sgz_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sgz00260]
sgz_M00621  Glycine cleavage system [PATH:sgz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces globosus [GN:sgz]
Gene
C0216_01375  aspartate kinase [KO:K00928] [EC:2.7.2.4]
C0216_25800  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
C0216_01380  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
C0216_05595  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
C0216_05605  homoserine kinase [KO:K00872] [EC:2.7.1.39]
C0216_28825  threonine synthase [KO:K01733] [EC:4.2.3.1]
C0216_04420  threonine synthase [KO:K01733] [EC:4.2.3.1]
C0216_05600  threonine synthase [KO:K01733] [EC:4.2.3.1]
C0216_31665  threonine aldolase [KO:K01620] [EC:4.1.2.48]
C0216_18960  threonine aldolase [KO:K01620] [EC:4.1.2.48]
C0216_03470  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
C0216_05645  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
C0216_06150  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
C0216_10170  glycerate kinase [KO:K00865] [EC:2.7.1.165]
C0216_29030  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
C0216_06355  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
C0216_28500  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
C0216_30385  hydrolase [KO:K01079] [EC:3.1.3.3]
C0216_22330  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
C0216_18665  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
C0216_18670  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
C0216_20295  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
C0216_06160  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
C0216_23935  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
C0216_06155  gcvH; glycine cleavage system protein GcvH [KO:K02437]
C0216_32535  glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
C0216_14490  amidinotransferase [KO:K00613] [EC:2.1.4.1]
C0216_10195  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
C0216_06905  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
C0216_06940  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
C0216_09975  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
C0216_27265  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
C0216_30365  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
C0216_06145  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
C0216_32915  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
C0216_03930  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
C0216_11635  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
C0216_23225  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
C0216_23230  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
C0216_29525  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
C0216_07480  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
C0216_09935  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
C0216_09940  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
C0216_31275  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
C0216_09930  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
C0216_09925  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
C0216_23095  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
C0216_26185  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sgz00010  Glycolysis / Gluconeogenesis
sgz00020  Citrate cycle (TCA cycle)
sgz00230  Purine metabolism
sgz00250  Alanine, aspartate and glutamate metabolism
sgz00270  Cysteine and methionine metabolism
sgz00290  Valine, leucine and isoleucine biosynthesis
sgz00300  Lysine biosynthesis
sgz00330  Arginine and proline metabolism
sgz00460  Cyanoamino acid metabolism
sgz00470  D-Amino acid metabolism
sgz00564  Glycerophospholipid metabolism
sgz00600  Sphingolipid metabolism
sgz00620  Pyruvate metabolism
sgz00630  Glyoxylate and dicarboxylate metabolism
sgz00640  Propanoate metabolism
sgz00680  Methane metabolism
sgz00860  Porphyrin metabolism
sgz00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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