KEGG   PATHWAY: spad00260
Entry
spad00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces paludis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
spad00260  Glycine, serine and threonine metabolism
spad00260

Module
spad_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:spad00260]
spad_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:spad00260]
spad_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:spad00260]
spad_M00621  Glycine cleavage system [PATH:spad00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces paludis [GN:spad]
Gene
DVK44_14270  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DVK44_09285  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DVK44_14265  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DVK44_33680  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DVK44_24410  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DVK44_24420  homoserine kinase [KO:K00872] [EC:2.7.1.39]
DVK44_33610  hypothetical protein [KO:K02204] [EC:2.7.1.39]
DVK44_24415  threonine synthase [KO:K01733] [EC:4.2.3.1]
DVK44_01370  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DVK44_10270  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DVK44_24490  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DVK44_25285  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DVK44_29715  glycerate kinase [KO:K00865] [EC:2.7.1.165]
DVK44_24120  glycerate kinase [KO:K00865] [EC:2.7.1.165]
DVK44_18765  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
DVK44_36040  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
DVK44_01820  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
DVK44_27505  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DVK44_32045  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DVK44_25565  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DVK44_01060  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DVK44_19600  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
DVK44_05075  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DVK44_15365  hydrolase [KO:K01079] [EC:3.1.3.3]
DVK44_27905  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
DVK44_27910  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DVK44_05875  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
DVK44_00550  monoamine oxidase [KO:K00276] [EC:1.4.3.21]
DVK44_02835  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
DVK44_25295  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
DVK44_33135  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DVK44_06845  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DVK44_25290  gcvH; glycine cleavage system protein GcvH [KO:K02437]
DVK44_30755  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
DVK44_29720  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DVK44_21550  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
DVK44_22710  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
DVK44_26075  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DVK44_26110  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DVK44_29080  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
DVK44_32245  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
DVK44_01685  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DVK44_01675  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DVK44_01690  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DVK44_01680  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DVK44_21255  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
DVK44_15345  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
DVK44_25280  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DVK44_22555  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
DVK44_25075  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
DVK44_06095  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
DVK44_06100  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
DVK44_14925  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
DVK44_26665  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
DVK44_10035  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
DVK44_14930  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
spad00010  Glycolysis / Gluconeogenesis
spad00020  Citrate cycle (TCA cycle)
spad00230  Purine metabolism
spad00250  Alanine, aspartate and glutamate metabolism
spad00270  Cysteine and methionine metabolism
spad00290  Valine, leucine and isoleucine biosynthesis
spad00300  Lysine biosynthesis
spad00330  Arginine and proline metabolism
spad00460  Cyanoamino acid metabolism
spad00470  D-Amino acid metabolism
spad00564  Glycerophospholipid metabolism
spad00600  Sphingolipid metabolism
spad00620  Pyruvate metabolism
spad00630  Glyoxylate and dicarboxylate metabolism
spad00640  Propanoate metabolism
spad00680  Methane metabolism
spad00860  Porphyrin metabolism
spad00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system