| |
KO |
 Ubiquitins and ubiquitin-like proteins
|
|
|
Ubiquitin-activating enzymes (E1)
|
|
|
Ubiquitin-conjugating enzymes (E2)
|
|
|
 Ubiquitin ligases (E3)
|
HECT type E3
|
U-box type E3
|
Single Ring-finger type E3
|
BRE1 proteins
|
CBL proteins
|
SINA (Seven in absentia) proteins
|
Ligand of Numb proteins
|
March proteins
|
MDM2/MDM4 proteins
|
NFX1 proteins
|
Pellino proteins
|
Peripheral membrane proteins
|
RBR proteins
|
TRAF proteins
|
TRIM/RBCC proteins
|
UBR box proteins
|
 ATL proteins
|
Other single Ring-finger type E3
|
109572524 AMFR; E3 ubiquitin-protein ligase AMFR
109563362 AIRE; autoimmune regulator
109578519 BFAR; bifunctional apoptosis regulator
109555878 baculoviral IAP repeat-containing protein 2 isoform X1
109568764 BIRC3; baculoviral IAP repeat-containing protein 3
109569840 BIRC2; baculoviral IAP repeat-containing protein 2
109567657 BIRC7; baculoviral IAP repeat-containing protein 7
109571078 BRAP; BRCA1-associated protein
109573698 BRCA1; breast cancer type 1 susceptibility protein isoform X1
109557391 CBLL1; E3 ubiquitin-protein ligase Hakai isoform X1
109564887 CCNB1IP1; E3 ubiquitin-protein ligase CCNB1IP1
109571354 CHFR; E3 ubiquitin-protein ligase CHFR
109557665 CNOT4; CCR4-NOT transcription complex subunit 4 isoform X1
109556988 DCST1; DC-STAMP domain-containing protein 1 isoform X1
109555358 DTX3L; E3 ubiquitin-protein ligase DTX3L
109578605 DTX2; probable E3 ubiquitin-protein ligase DTX2 isoform X1
109571295 DTX1; E3 ubiquitin-protein ligase DTX1
109559317 DTX3; probable E3 ubiquitin-protein ligase DTX3 isoform X1
109569626 DTX4; E3 ubiquitin-protein ligase DTX4 isoform X1
109570236 DZIP3; E3 ubiquitin-protein ligase DZIP3 isoform X1
109566096 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1
109566183 KCMF1; E3 ubiquitin-protein ligase KCMF1
109566480 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 isoform X1
109557720 LTN1; E3 ubiquitin-protein ligase listerin isoform X1
109574889 MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1
109553376 MEX3A; RNA-binding protein MEX3A
109577889 MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C
109575660 MEX3B; LOW QUALITY PROTEIN: RNA-binding protein MEX3B
109561065 MEX3D; RNA-binding protein MEX3D
109570119 E3 ubiquitin-protein ligase MGRN1-like
109578422 MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1
109577765 MIB1; E3 ubiquitin-protein ligase MIB1
109570465 MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1
109557956 MKRN1; E3 ubiquitin-protein ligase makorin-1
109576054 MKRN2; probable E3 ubiquitin-protein ligase makorin-2
109574300 MUL1; mitochondrial ubiquitin ligase activator of NFKB 1
109566887 MYCBP2; E3 ubiquitin-protein ligase MYCBP2 isoform X1
109577215 MYLIP; E3 ubiquitin-protein ligase MYLIP
109579112 NEURL1; E3 ubiquitin-protein ligase NEURL1
109574908 NEURL1B; E3 ubiquitin-protein ligase NEURL1B isoform X1
109565770 NEURL3; E3 ubiquitin-protein ligase NEURL3 isoform X1
109577374 NHLRC1; E3 ubiquitin-protein ligase NHLRC1
109566891 RNF219; RING finger protein 219
109554869 PJA1; E3 ubiquitin-protein ligase Praja-1
109562377 PJA2; E3 ubiquitin-protein ligase Praja-2
109576438 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1
109569432 RAG1; V(D)J recombination-activating protein 1
109560585 RCHY1; RING finger and CHY zinc finger domain-containing protein 1
109566431 RC3H2; roquin-2 isoform X1
109566445 roquin-2-like isoform X1
109570185 RC3H1; roquin-1
109570511 RFWD2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RFWD2
109572763 RFWD3; E3 ubiquitin-protein ligase RFWD3 isoform X1
109570618 RNF2; E3 ubiquitin-protein ligase RING2
109576601 RING1; E3 ubiquitin-protein ligase RING1
109560733 RNF4; E3 ubiquitin-protein ligase RNF4
109576854 RNF5; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF5
109571287 RNF185; E3 ubiquitin-protein ligase RNF185
109566839 RNF6; E3 ubiquitin-protein ligase RNF6
109577274 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X1
109571202 RNF10; RING finger protein 10
109556876 RNF11; RING finger protein 11
109555554 E3 ubiquitin-protein ligase RLIM-like
109555265 RLIM; E3 ubiquitin-protein ligase RLIM
109559300 RNF13; E3 ubiquitin-protein ligase RNF13
109570692 RNF25; E3 ubiquitin-protein ligase RNF25 isoform X1
109569814 RNF26; RING finger protein 26
109563035 RNF38; E3 ubiquitin-protein ligase RNF38
109561883 RNF44; RING finger protein 44 isoform X1
109559369 RNF41; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NRDP1
109574133 RNF43; E3 ubiquitin-protein ligase RNF43
109566153 RNF103; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF103
109565084 RNF111; E3 ubiquitin-protein ligase Arkadia isoform X1
109573263 RNF112; RING finger protein 112
109567541 RNF114; E3 ubiquitin-protein ligase RNF114
109555837 RNF115; E3 ubiquitin-protein ligase RNF115 isoform X1
109561965 RNF126; E3 ubiquitin-protein ligase RNF126 isoform X1
109569218 RNF121; RING finger protein 121 isoform X1
109570852 RNF175; LOW QUALITY PROTEIN: RING finger protein 175
109553488 RNF122; RING finger protein 122 isoform X1
109575996 RNF123; E3 ubiquitin-protein ligase RNF123 isoform X1
109577894 RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1
109554824 RNF128; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF128
109561332 RNF130; E3 ubiquitin-protein ligase RNF130
109557578 RNF133; E3 ubiquitin-protein ligase RNF133
109574036 RNF135; E3 ubiquitin-protein ligase RNF135 isoform X1
109577945 RNF138; E3 ubiquitin-protein ligase RNF138 isoform X1
109568196 RNF139; E3 ubiquitin-protein ligase RNF139 isoform X1
109562259 RNF145; RING finger protein 145
109567008 E3 ubiquitin-protein ligase RNF146-B-like
109563747 RNF146; E3 ubiquitin-protein ligase RNF146
109571492 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF146-A-like
109565500 RNF149; E3 ubiquitin-protein ligase RNF149
109573913 RNF157; RING finger protein 157
109577672 RNF165; RING finger protein 165
109572322 RNF166; RING finger protein 166
109573781 RNF167; E3 ubiquitin-protein ligase RNF167
109553460 RNF170; E3 ubiquitin-protein ligase RNF170 isoform X1
109575065 RNF180; E3 ubiquitin-protein ligase RNF180 isoform X1
109566170 RNF181; E3 ubiquitin-protein ligase RNF181 isoform X1
109577443 RNF182; E3 ubiquitin-protein ligase RNF182
109577197 RNF186; RING finger protein 186
109561361 RNF187; E3 ubiquitin-protein ligase RNF187
109573339 E3 ubiquitin-protein ligase RNF213-like
109573340 E3 ubiquitin-protein ligase RNF213-like
109556382 RNF220; E3 ubiquitin-protein ligase RNF220 isoform X1
109573727 RNFT1; LOW QUALITY PROTEIN: RING finger and transmembrane domain-containing protein 1
109554506 SART1; U4/U6.U5 tri-snRNP-associated protein 1
109564015 SHPRH; E3 ubiquitin-protein ligase SHPRH
109566112 SH3RF3; SH3 domain-containing RING finger protein 3
109561097 SH3RF2; putative E3 ubiquitin-protein ligase SH3RF2
109562752 SH3RF1; E3 ubiquitin-protein ligase SH3RF1 isoform X1
109559403 HLTF; helicase-like transcription factor isoform X1
109554397 SYVN1; E3 ubiquitin-protein ligase synoviolin
109560722 TMEM129; E3 ubiquitin-protein ligase TM129
109562814 TOPORS; E3 ubiquitin-protein ligase Topors isoform X1
109576305 TRAIP; E3 ubiquitin-protein ligase TRAIP
109561569 TTC3; E3 ubiquitin-protein ligase TTC3 isoform X1
109560960 UHRF1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UHRF1
109562892 UHRF2; E3 ubiquitin-protein ligase UHRF2
109578481 UNKL; putative E3 ubiquitin-protein ligase UNKL isoform X1
109578607 ZNF598; LOW QUALITY PROTEIN: zinc finger protein 598
109569573 ZFP91; E3 ubiquitin-protein ligase ZFP91
109572556 ZNRF1; E3 ubiquitin-protein ligase ZNRF1
109557479 ZNRF2; E3 ubiquitin-protein ligase ZNRF2 isoform X1
109560959 ZNRF4; E3 ubiquitin-protein ligase ZNRF4
109565728 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2
|
K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
K10603 AIRE; autoimmune regulator
K15684 BFAR; bifunctional apoptosis regulator
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
K04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K15689 NEURL3; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27]
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27]
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27]
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
K11980 RNF11; E3 ubiquitin-protein ligase RNF11
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
K15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
K15694 RNF43; E3 ubiquitin-protein ligase RNF43 [EC:2.3.2.27]
K15695 RNF103; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27]
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
K25173 RNF112; E3 ubiquitin-protein ligase RNF112 [EC:2.3.2.27]
K15697 RNF114; E3 ubiquitin-protein ligase RNF114 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K15698 RNF121_175; RING finger protein 121/175
K15698 RNF121_175; RING finger protein 121/175
K15699 RNF122; RING finger protein 122
K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K10629 RNF128; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]
K15701 RNF130; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27]
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
K23789 RNF145; E3 ubiquitin-protein ligase RNF145 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27]
K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
K17821 RNF165; E3 ubiquitin-protein ligase RNF165 [EC:2.3.2.27]
K17044 RNF166; E3 ubiquitin-protein ligase RNF166 [EC:2.3.2.27]
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27]
K25214 RNF186; E3 ubiquitin-protein ligase RNF186 [EC:2.3.2.27]
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27]
K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]
K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
K15713 UHRF2; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27]
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
K25175 ZFP91; E3 ubiquitin-protein ligase ZFP91 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K15715 ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
|
Atypical E3
|
UBL E3 ligases
|
Multi subunit Ring-finger type E3
|
SCF complex
|
Cul2 complex
|
Cul3 complex
|
Cul4 complex
|
Cul5 complex
|
Cul7 complex
|
Cul8 complex
|
Cul9 complex
|
APC/C
|
BRCC complex
|
109573698 BRCA1; breast cancer type 1 susceptibility protein isoform X1
109566792 BRCA2; breast cancer type 2 susceptibility protein
109570424 BARD1; BRCA1-associated RING domain protein 1
109566264 BRE; BRCA1-A complex subunit BRE
109564943 RAD51; DNA repair protein RAD51 homolog 1
|
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K08775 BRCA2; breast cancer 2 susceptibility protein
K10683 BARD1; BRCA1-associated RING domain protein 1
K12173 BRE; BRCA1-A complex subunit BRE
K04482 RAD51; DNA repair protein RAD51
|
KPC complex
|
LUBAC complex
|
CTLH complex
|
ERAD complex
|
LMBR1L-GP78-UBAC2 complex
|
SLX5-SLX8 complex
|
Multi subunit type E3 associated proteins
|
|
|
Deubiquitinating enzyme (DUB)
|
Ubiquitin System - Bos indicus (zebu cattle)