KEGG ORTHOLOGY: K15712

ORTHOLOGY: K15712

Entry

K15712                      KO

Symbol

TTC3

Name

E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K15712  TTC3; E3 ubiquitin-protein ligase TTC3
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K15712  TTC3; E3 ubiquitin-protein ligase TTC3
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K15712  TTC3; E3 ubiquitin-protein ligase TTC3

Genes

HSA:	7267(TTC3)

PTR:	100611158 747390(TTC3)

PPS:	100978411(TTC3) 100979877

GGO:	101140932 101141159(TTC3)

PON:	100451950 100457794(TTC3)

PPYG:

129022589(TTC3) 129025272

NLE:	100600260(TTC3)

HMH:	116482395(TTC3) 116811821

SSYN:

129475753 129482979(TTC3)

MCC:	694206(TTC3)

MCF:	102131356(TTC3)

MTHB:

126946203 126950708

MNI:	105472652(TTC3)

CSAB:

103218693(TTC3)

CATY:

105575428(TTC3)

PANU:

101009153(TTC3)

TGE:	112620229(TTC3)

MLEU:

105533333 105545015(TTC3)

RRO:	104655259 104678757(TTC3)

RBB:	108543825(TTC3) 108544571

TFN:	117077653 117095763(TTC3)

PTEH:

111525798(TTC3) 111536215

CANG:

105520345(TTC3)

CJC:	100394473(TTC3)

SBQ:	101050963(TTC3)

CIMI:

108302566(TTC3)

ANAN:

105712524(TTC3)

CSYR:

103264411(TTC3)

MMUR:

105881290(TTC3)

LCAT:

123630734(TTC3)

PCOQ:

105806859(TTC3)

OGA:	100961801(TTC3)

MMU:	22129(Ttc3)

MCAL:

110311154(Ttc3)

MPAH:

110329716(Ttc3)

RNO:	360702(Ttc3)

MCOC:

116083832(Ttc3)

ANU:	117717765(Ttc3)

ASYL:

127666202(Ttc3)

MUN:	110560963(Ttc3)

CGE:	100750887(Ttc3)

MAUA:

101824878(Ttc3)

PROB:

127227547(Ttc3)

PLEU:

114700370(Ttc3)

MORG:

121461981(Ttc3)

MFOT:

126513587

AAMP:

119824605(Ttc3)

NGI:	103750094(Ttc3)

HGL:	101722149(Ttc3)

CPOC:

100715382(Ttc3)

CCAN:

109693416(Ttc3)

DORD:

105994012(Ttc3)

DSP:	122114193(Ttc3)

DMER:

138832527(Ttc3)

PLOP:

125351459(Ttc3)

NCAR:

124993024

MMMA:

107136473(Ttc3)

ITI:	101955864(Ttc3)

OCU:

100349795

OPI:	101522829(TTC3)

TUP:	102498860(TTC3)

GVR:

103604270

CFA:	478414(TTC3)

CLUD:

112661897(TTC3)

VVP:	112911374(TTC3)

VLG:	121479575(TTC3)

NPO:	129502130(TTC3)

UMR:	103673153(TTC3)

UAH:	113259111(TTC3)

UAR:	123802657(TTC3)

ELK:

111155775

LLV:

125094477

MPUF:

101693875(TTC3)

MNP:	132012392(TTC3)

MLK:	131825366(TTC3)

NVS:	122908296(TTC3)

ORO:	101367714(TTC3)

EJU:	114218548(TTC3)

ZCA:	113916265(TTC3)

MLX:	118000433(TTC3)

NSU:	110570103(TTC3)

LWW:	102735989(TTC3)

FCA:	101081324(TTC3)

PYU:	121035946(TTC3)

PCOO:

112850161(TTC3)

PBG:	122491176(TTC3)

PVIV:

125175649(TTC3)

LRUF:

124526260

LGF:	123610588(TTC3)

AJU:

106966987

PTG:	102965328(TTC3)

PPAD:

109249776(TTC3)

PUC:

125920735

PLEZ:

122229395(TTC3)

HHV:	120229157(TTC3)

BTA:	506569(TTC3)

BOM:	102275595(TTC3)

BIU:	109561569(TTC3)

BBUB:

102401979(TTC3)

BBIS:

104984883(TTC3)

CHX:	102174881(TTC3)

OAS:	101116444(TTC3)

BTAX:

128052449(TTC3)

CSUM:

138069390(TTC3)

ODA:	120880610(TTC3)

CCAD:

122445476(TTC3)

MREE:

136173627(TTC3)

OVR:	110123108(TTC3)

MBEZ:

129549224(TTC3)

SSC:	106505861(TTC3)

CFR:	102512536(TTC3)

CBAI:

105070199(TTC3)

CDK:	105089835(TTC3)

VPC:	102539247(TTC3)

BACU:

103010693(TTC3)

BMUS:

118894719(TTC3)

LVE:	103082018(TTC3)

OOR:	101270100(TTC3)

LALB:

132521336(TTC3)

GMF:	115865820(TTC3)

DLE:	111163891(TTC3)

PCAD:

102988073(TTC3)

PSIU:

116752839(TTC3)

PPHC:

136122416(TTC3)

NASI:

112408586(TTC3)

ECB:	100060967(TTC3)

EPZ:	103550466(TTC3)

EAI:	106831410(TTC3)

MYB:	102263867(TTC3)

MYD:	102766121(TTC3)

MMYO:

118677286(TTC3)

MLF:	102441984(TTC3)

MDT:	132229867(TTC3)

MYUM:

139004297(TTC3)

PKL:	118722283(TTC3)

EFUS:

103289908(TTC3)

MNA:	107543193(TTC3)

DRO:	112305782(TTC3)

SHON:

118983281(TTC3)

AJM:	119035731(TTC3)

PDIC:

114490498(TTC3)

PHAS:

123827965(TTC3)

MMF:	118616814(TTC3)

PPAM:

129074439(TTC3)

HAI:	109389848(TTC3)

RFQ:	117036522(TTC3)

PALE:

102888592(TTC3)

PGIG:

120598724(TTC3)

PVP:	105295812(TTC3)

RAY:	107499286(TTC3)

MJV:	108393955(TTC3)

TOD:	119257200(TTC3)

SARA:

101556820(TTC3)

SFUM:

130028543(TTC3)

SETR:

125999493 126025892(TTC3)

LAV:	100675887(TTC3)

TMU:

101361833

ETF:	101656225(TTC3)

DNM:	101428621(TTC3)

MDO:	100618256(TTC3)

GAS:	123242490(TTC3)

SHR:	100927756(TTC3)

AFZ:

127553833

PCW:	110214764(TTC3)

TVP:	118840463(TTC3)

PBRV:

138151495(TTC3)

MLAO:

141506848(TTC3)

OAA:	100078590(TTC3)

TACU:

119939930(TTC3)

GGA:	418518(TTC3)

PCOC:

116242064(TTC3)

MGP:	100544851(TTC3)

CJO:	107323371(TTC3)

TPAI:

128076319(TTC3)

LMUT:

125684684(TTC3)

NMEL:

110402831(TTC3)

APLA:

101795951(TTC3)

ACYG:

106036085(TTC3)

CATA:

118247751(TTC3)

AFUL:

116488581(TTC3)

TGU:	100227441(TTC3)

LSR:	110469053(TTC3)

SCAN:

103815872(TTC3)

PMOA:

120511813(TTC3)

OTC:	121333567(TTC3)

PRUF:

121364483(TTC3)

ATRC:

139591496(TTC3)

GFR:	102040293(TTC3)

FAB:	101812472(TTC3)

OMA:	130262700(TTC3)

PHI:	102108891(TTC3)

PMAJ:

107207913(TTC3)

CCAE:

111928582(TTC3)

CCW:	104696760(TTC3)

CBRC:

103617047(TTC3)

ACOE:

138108185(TTC3)

ETL:	114070495(TTC3)

ZAB:

102060534

ZLE:	135444090(TTC3)

ACHL:

103801451(TTC3)

SVG:	106855740(TTC3)

MMEA:

130579995(TTC3)

HRT:	120748667(TTC3)

SATI:

136358218(TTC3)

CCIC:

134041416(TTC3)

FPG:	101921367(TTC3)

FCH:	102052831(TTC3)

NNT:	104408428(TTC3)

SHAB:

115601619(TTC3)

ACUN:

113484556(TTC3)

TALA:

104363647(TTC3)

ACHC:

115343974(TTC3)

HALD:

104318110(TTC3)

HLE:	104839809(TTC3)

AGEN:

126053285

HHAR:

128145112(TTC3)

GCL:

127029541

MNB:	103771896(TTC3)

DPUB:

104304942(TTC3)

PPUS:

135180183(TTC3)

AVIT:

104267128(TTC3)

BRHI:

104491749

EGZ:	104128177(TTC3)

NNI:	104020184(TTC3)

PCRI:

104031472(TTC3)

PCAO:

104049052(TTC3)

PADL:

103920280(TTC3)

AFOR:

103901996(TTC3)

FGA:

104083084

GSTE:

104262382(TTC3)

CBOY:

140644005(TTC3)

CLV:	102086359(TTC3)

CNIC:

135984569(TTC3)

MUI:	104542609(TTC3)

PGUU:

104469228(TTC3)

PLET:

104617433(TTC3)

EHS:

104505291

CMAC:

104481195(TTC3)

CUCA:

104059256(TTC3)

TEO:	104380280(TTC3)

BREG:

104643306(TTC3)

OHA:	104327714(TTC3)

ACAR:

104521191

CPEA:

104391200(TTC3)

CVF:	104292042(TTC3)

RTD:	128910575(TTC3)

CRID:

134520367(TTC3)

AAM:	106494950(TTC3)

AROW:

112971865(TTC3)

NPD:	112959071(TTC3)

TGT:	104580836(TTC3)

DNE:	112996163(TTC3)

SCAM:

104139429(TTC3)

ASN:	102384615(TTC3)

AMJ:	102565641(TTC3)

CPOO:

109305812(TTC3)

GGN:	109302502(TTC3)

PSS:	102451121(TTC3)

CMY:	102946582(TTC3)

CCAY:

125643805(TTC3)

DCC:	119850149(TTC3)

CPIC:

101935113(TTC3)

TST:	117867548(TTC3)

CABI:

116834827(TTC3)

MRV:	120385951(TTC3)

ACS:	100562480(ttc3)

ASAO:

132771855(TTC3)

PVT:	110076810(TTC3)

SUND:

121926781(TTC3)

PBI:	103048673(TTC3)

PMUR:

107296847(TTC3)

CTIG:

120320307(TTC3)

TSR:	106540932(TTC3)

PGUT:

117679667(TTC3)

PCAE:

139317271(TTC3)

APRI:

131199124(TTC3)

PTEX:

113436239(TTC3)

NSS:	113409907(TTC3)

VKO:	123029334(TTC3)

PMUA:

114596083(TTC3)

PRAF:

128413017(TTC3)

ZVI:	118085776(TTC3)

HCG:	128349817(TTC3)

GJA:	107115896(TTC3)

STOW:

125432223(TTC3)

EMC:	129325483(TTC3)

XLA:

108707415

XTR:	100492684(ttc3)

NPR:	108785945(TTC3)

RTEM:

120927943(TTC3)

ACAT:

141129272(TTC3)

BBUF:

120994489(TTC3)

BGAR:

122930790(TTC3) 122930794

DTC:	141097467(TTC3)

PWL:	138248710 138248711

MUO:

115469500

GSH:	117362356(TTC3)

DRE:	100005214(ttc3)

SRX:	107744207 107747360

SANH:

107671623 107676488(ttc3)

SGH:	107565542(ttc3) 107572950

CCAR:

109076829 109076835

CAUA:

113054770 113086316

CGIB:

127966213 127985545 128020928 128020929

PTET:

122333933(ttc3)

LROH:

127172016(ttc3)

GRF:	141299801(ttc3)

OMC:	131548107(ttc3)

PPRM:

120478420(ttc3)

MAMB:

125262585(ttc3)

CIDE:

127521939

CERY:

137028453(ttc3)

MASI:

127432499 127433872

TROS:

130545863(ttc3)

TDW:	130412015(ttc3)

MANU:

129446352(ttc3)

PDAB:

135746266(ttc3)

IPU:

108276906

IFU:	128620804(ttc3)

PHYP:

113543548(ttc3)

SMEO:

124393469(ttc3)

TFD:	113645692(ttc3)

TVC:	132863284(ttc3)

CGAR:

128545456(ttc3)

NGRA:

132873647(ttc3)

TRN:	134332803(ttc3)

AMEX:

103047569(ttc3)

CMAO:

118824543(ttc3)

EEE:	113581662(ttc3)

CHAR:

105902084(ttc3)

SPIL:

134080174(ttc3)

TRU:	105417445(ttc3)

TFS:	130537012(ttc3)

LCO:	104918975(ttc3)

TBEN:

117490300(ttc3)

CGOB:

115018477

PGEO:

117458380(ttc3)

GACU:

117554559(ttc3)

EMAC:

134872639(ttc3)

ELY:	117265315(ttc3)

EFO:

125898834

PLEP:

121952442(ttc3)

SLUC:

116055966(ttc3)

ECRA:

117954983(ttc3)

ESP:	116701098(ttc3)

PFLV:

114566834(ttc3)

GAT:	120821898(ttc3)

PPUG:

119215155(ttc3)

AFB:	129113657(ttc3)

CLUM:

117742351(ttc3)

CANA:

137802143(ttc3)

CVE:	137876220(ttc3)

MSAM:

119894982(ttc3)

SCHU:

122887953(ttc3)

CUD:	121518624(ttc3)

SPUL:

138603246(ttc3)

LMIX:

132988846(ttc3)

ALAT:

119031768(ttc3)

ASTR:

137605992(ttc3)

MZE:	101480900(ttc3)

ONL:	100693809(ttc3)

OAU:	116319018(ttc3)

OLA:	101161328(ttc3)

OML:	112142611(ttc3)

CSAI:

133460060(ttc3)

XMA:

XCO:

XHE:

PFOR:

PLAI:

PMEI:

GAF:	122844757(ttc3)

PPRL:

129356326(ttc3)

CVG:

107098405

CTUL:

119774435(ttc3)

GMU:	124876011(ttc3)

NFU:	107386626(ttc3)

KMR:	108238071(ttc3)

ALIM:

106530609

NWH:	119420434(ttc3)

AOCE:

111563008(ttc3)

EJA:	138196072(ttc3)

BFRE:

138627440(ttc3)

MCEP:

125020938(ttc3)

CSEM:

103394921

POV:	109628636(ttc3)

SSEN:

122779355(ttc3)

SSOE:

131458315(ttc3)

HHIP:

117774204(ttc3)

HSP:	118121973(ttc3)

PPLT:

128456705(ttc3)

SMAU:

118300383(ttc3)

LCF:

108893696

SDU:	111234527(ttc3)

SLAL:

111659964(ttc3)

XGL:	120802236(ttc3)

HCQ:	109517604(ttc3)

SSCV:

125981878(ttc3)

SBIA:

133491744(ttc3)

PEE:	133415810(ttc3)

PTAO:

133467182(ttc3)

BPEC:

110166326(ttc3)

ENY:	140361238(ttc3)

MALB:

109959253(ttc3)

BSPL:

114869394(ttc3)

SJO:	128371808 128371926

SSCO:

133994495(ttc3) 133994496

GMH:	115546759(ttc3)

SASA:

106567687 106603445

STRU:

115148760 115154226

OTW:	112257953(ttc3)

OMY:	110537571(ttc3)

OGO:

123998767

ONE:	115105456(ttc3)

OKI:

109892825

OKE:	118391079(ttc3)

OMM:

135548693

OCLA:

139423178

SALP:

111982048

SNH:	120030973(ttc3) 120056998

CCLU:

121550221 121579355

ELS:	105011070(ttc3)

OEP:	134039286(ttc3)

SFM:	108936069(ttc3)

PKI:	111858420(ttc3)

AANG:

118235079(ttc3)

AROT:

135263324(ttc3)

CCOG:

133132991(ttc3)

LOC:

102689713

PSPA:

121302836(ttc3)

ARUT:

117405150 117406497

LCM:

102348236

CMK:	103180318 103189167

RTP:

109934963

CPLA:

122555388(ttc3)

HOC:	132821178(ttc3)

LERI:

129702995(ttc3)

HAKA:

140727537(ttc3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	585630 592552

APLC:

SKO:

CGLO:

FAS:

DAM:

FOC:	113204899 113206514

TPAL:

ZNE:

CSEC:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

EAF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

SDM:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

AQU:

Reference

PMID:20059950

Authors

Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M

Title

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

Journal

Dev Cell 17:800-10 (2009)
DOI:10.1016/j.devcel.2009.09.007

Sequence

[hsa:7267]

LinkDB

DBGET integrated database retrieval system