KEGG   ORTHOLOGY: K10144
Entry
K10144                      KO                                     
Symbol
RCHY1, PIRH2
Name
RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
Pathway
map04115  p53 signaling pathway
map04120  Ubiquitin mediated proteolysis
map05162  Measles
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10144  RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1
Genes
HSA: 25898(RCHY1)
PTR: 461248(RCHY1)
PPS: 100970552(RCHY1)
GGO: 101142111(RCHY1)
PON: 100446564(RCHY1)
PPYG: 129035425(RCHY1)
NLE: 100592655(RCHY1)
HMH: 116466864(RCHY1)
SSYN: 129492244(RCHY1)
MCC: 701580(RCHY1)
MCF: 102144301(RCHY1)
MTHB: 126954906
MNI: 105477274(RCHY1)
CSAB: 103235812(RCHY1)
CATY: 105576868(RCHY1)
PANU: 101017011(RCHY1)
TGE: 112624520(RCHY1)
MLEU: 105529103(RCHY1)
RRO: 104673166(RCHY1)
RBB: 108532499(RCHY1)
TFN: 117085473(RCHY1)
PTEH: 111524565(RCHY1)
CANG: 105501311(RCHY1)
CJC: 100413993(RCHY1)
SBQ: 101054077(RCHY1)
CIMI: 108293407(RCHY1)
ANAN: 105713320(RCHY1)
CSYR: 103271577(RCHY1)
MMUR: 105860109(RCHY1)
LCAT: 123624726(RCHY1)
PCOQ: 105822818(RCHY1)
OGA: 100951668(RCHY1)
MMU: 68098(Rchy1)
MCAL: 110294340(Rchy1)
MPAH: 110330495(Rchy1)
RNO: 289508(Rchy1)
MCOC: 116104481(Rchy1)
ANU: 117712687(Rchy1)
MUN: 110555423(Rchy1)
CGE: 100754452(Rchy1)
MAUA: 101835747(Rchy1)
PROB: 127232390(Rchy1)
PLEU: 114701743(Rchy1)
MORG: 121460710(Rchy1)
AAMP: 119812740(Rchy1)
NGI: 103742440(Rchy1)
HGL: 101700191(Rchy1)
CCAN: 109698576(Rchy1)
DORD: 105988578(Rchy1)
DSP: 122106685(Rchy1)
PLOP: 125364589(Rchy1) 125366183
NCAR: 124994453
MMMA: 107153721(Rchy1)
OCU: 100342142
OPI: 101533776(RCHY1)
TUP: 102478505(RCHY1)
GVR: 103586149(RCHY1)
CFA: 612746(RCHY1)
CLUD: 112647158(RCHY1)
VVP: 112915542(RCHY1)
VLG: 121479527 121493555(RCHY1)
NPO: 129501887(RCHY1)
AML: 100467233(RCHY1)
UMR: 103665320(RCHY1)
UAH: 113263266(RCHY1)
UAR: 123787156(RCHY1)
ELK: 111148970
LLV: 125093837
MPUF: 101671466(RCHY1)
MNP: 132007125(RCHY1)
MLK: 131823028(RCHY1)
NVS: 122919238(RCHY1)
ORO: 101382341(RCHY1)
EJU: 114206775(RCHY1)
ZCA: 113924554(RCHY1)
MLX: 118010446(RCHY1)
NSU: 110591343(RCHY1)
LWW: 102748779(RCHY1)
FCA: 101080785(RCHY1)
PYU: 121034203(RCHY1)
PCOO: 112859098(RCHY1)
PBG: 122478787(RCHY1)
PVIV: 125163529(RCHY1)
LRUF: 124519995
PTG: 102955633(RCHY1)
PPAD: 109277608(RCHY1)
PUC: 125923655
AJU: 106981721
HHV: 120231071(RCHY1)
BTA: 540733(RCHY1)
BOM: 102272825(RCHY1)
BIU: 109560585(RCHY1)
BBUB: 102393395(RCHY1)
BBIS: 104987305(RCHY1)
CHX: 102181578(RCHY1)
OAS: 100302546(RCHY1)
BTAX: 128049687(RCHY1)
ODA: 120861448(RCHY1)
CCAD: 122428092(RCHY1)
MBEZ: 129561779(RCHY1)
SSC: 100038006(RCHY1)
CFR: 102513863(RCHY1)
CBAI: 105080372(RCHY1)
CDK: 105091452(RCHY1)
VPC: 102533528(RCHY1)
BACU: 103020996(RCHY1)
BMUS: 118895540(RCHY1)
LVE: 103091133(RCHY1)
OOR: 101270901(RCHY1) 101280307
DLE: 111187569(RCHY1)
PCAD: 102994412(RCHY1)
PSIU: 116749321 116754155(RCHY1)
NASI: 112405605(RCHY1)
ECB: 100057332(RCHY1)
EPZ: 103552149(RCHY1)
EAI: 106846386(RCHY1)
MYB: 102260347(RCHY1)
MYD: 102753824(RCHY1)
MMYO: 118669918(RCHY1)
MLF: 102419875(RCHY1)
MDT: 132217917(RCHY1)
PKL: 118705202(RCHY1)
EFUS: 103287939(RCHY1) 103299112
MNA: 107532999(RCHY1)
DRO: 112321873(RCHY1)
SHON: 118974954 118990366(RCHY1)
AJM: 119052836
PDIC: 114492248(RCHY1)
PHAS: 123831147(RCHY1)
MMF: 118629552(RCHY1)
PPAM: 129085282(RCHY1)
RFQ: 117022336(RCHY1)
PALE: 102883456(RCHY1)
PGIG: 120588212(RCHY1)
PVP: 105292351(RCHY1)
RAY: 107515308(RCHY1)
MJV: 108384767(RCHY1)
TOD: 119260514(RCHY1)
SARA: 101558453(RCHY1)
SETR: 126032632(RCHY1)
LAV: 100664562(RCHY1)
TMU: 101356142
ETF: 101639309(RCHY1)
DNM: 101429895(RCHY1)
MDO: 100024151(RCHY1)
GAS: 123250986(RCHY1)
SHR: 100916490(RCHY1)
AFZ: 127541839
PCW: 110209784(RCHY1)
TVP: 118854546(RCHY1)
OAA: 100079678(RCHY1)
GGA: 771726(RCHY1)
PCOC: 116238030(RCHY1)
MGP: 104910570(RCHY1)
CJO: 107313202(RCHY1)
LMUT: 125692384(RCHY1)
NMEL: 110397682(RCHY1)
APLA: 101802500(RCHY1)
ACYG: 106035121(RCHY1)
CATA: 118249709(RCHY1)
AFUL: 116488875(RCHY1)
TGU: 100219468(RCHY1)
LSR: 110471211(RCHY1)
SCAN: 103823415(RCHY1)
PMOA: 120502702(RCHY1)
OTC: 121331976(RCHY1)
PRUF: 121349176(RCHY1)
GFR: 102041363(RCHY1)
FAB: 101820010(RCHY1)
OMA: 130252284(RCHY1)
PHI: 102110475(RCHY1)
PMAJ: 107202936(RCHY1)
CCAE: 111928985(RCHY1)
CCW: 104696864(RCHY1)
CBRC: 103618947(RCHY1)
ETL: 114067618(RCHY1)
ZAB: 102067012(RCHY1)
ZLE: 135446908(RCHY1)
ACHL: 103808114(RCHY1)
SVG: 106858304(RCHY1)
MMEA: 130583144(RCHY1)
HRT: 120753481(RCHY1)
SATI: 136360787(RCHY1)
FPG: 101921704(RCHY1)
FCH: 102052138(RCHY1)
CCRI: 104162580(RCHY1)
NNT: 104399734(RCHY1)
SHAB: 115605257(RCHY1)
ACUN: 113479647(RCHY1)
TALA: 104364195(RCHY1)
ACHC: 115347583(RCHY1)
HALD: 104311537(RCHY1)
HLE: 104836790(RCHY1)
AGEN: 126044905
GCL: 127016093
CSTI: 104550052(RCHY1)
LDI: 104354453(RCHY1)
MNB: 103781464(RCHY1)
AVIT: 104274661(RCHY1)
BRHI: 104501981(RCHY1)
EGZ: 104135718(RCHY1)
NNI: 104017518(RCHY1)
PCRI: 104036999(RCHY1)
PCAO: 104042789(RCHY1)
PADL: 103913864(RCHY1)
AFOR: 103901703(RCHY1)
FGA: 104076563(RCHY1)
GSTE: 104250634(RCHY1)
CLV: 102090104(RCHY1)
MUI: 104533681(RCHY1)
PGUU: 104471795(RCHY1)
PLET: 104622580(RCHY1)
EHS: 104516201(RCHY1)
CUCA: 104063906(RCHY1)
BREG: 104636571(RCHY1)
OHA: 104336730(RCHY1)
ACAR: 104522400(RCHY1)
CPEA: 104390599(RCHY1)
CVF: 104289272(RCHY1)
RTD: 128910665(RCHY1)
AAM: 106495341(RCHY1)
AROW: 112972173(RCHY1)
NPD: 112953452(RCHY1)
TGT: 104564799(RCHY1)
DNE: 112995356(RCHY1)
SCAM: 104152108(RCHY1)
ASN: 102379175(RCHY1)
AMJ: 102571365(RCHY1)
CPOO: 109309519(RCHY1)
PSS: 102452832(RCHY1)
CMY: 102947239(RCHY1)
CCAY: 125635295(RCHY1)
DCC: 119854247(RCHY1)
CPIC: 101933653(RCHY1)
TST: 117878063(RCHY1)
CABI: 116814580(RCHY1)
MRV: 120405957(RCHY1)
HCG: 128329506(RCHY1)
GJA: 107105566(RCHY1)
STOW: 125441082(RCHY1)
EMC: 129337592(RCHY1)
XLA: 496013(rchy1.L)
XTR: 496979(rchy1)
NPR: 108784455(RCHY1)
RTEM: 120916773(RCHY1)
BBUF: 120989790(RCHY1)
BGAR: 122944621(RCHY1)
MUO: 115461087(RCHY1)
GSH: 117367729(RCHY1)
DRE: 321875(rchy1)
SANH: 107667418(rchy1)
SGH: 107594595(rchy1)
PTET: 122346011(rchy1)
LROH: 127164744(rchy1)
OMC: 131541085(rchy1)
PPRM: 120469388(rchy1)
RKG: 130088163(rchy1)
MAMB: 125267272(rchy1)
CIDE: 127512535
CERY: 137033844(rchy1)
TROS: 130570288(rchy1)
TDW: 130420180(rchy1)
IPU: 108255627
IFU: 128598902(rchy1)
PHYP: 113528160(rchy1)
SMEO: 124380746(rchy1)
TFD: 113656746(rchy1)
TVC: 132854422(rchy1)
TRN: 134335314(rchy1)
AMEX: 103040499(rchy1)
CMAO: 118826991(rchy1)
EEE: 113589881(rchy1)
CHAR: 105902895(rchy1)
TRU: 101069635(rchy1)
TFS: 130525697(rchy1)
LCO: 104924988(rchy1)
NCC: 104963395(rchy1)
TBEN: 117498750(rchy1)
PGEO: 117452400(rchy1)
GACU: 117546228(rchy1)
EMAC: 134873020(rchy1)
ELY: 117251937(rchy1)
EFO: 125890671(rchy1)
PLEP: 121944892(rchy1)
SLUC: 116050503(rchy1)
ECRA: 117944973(rchy1)
ESP: 116690064(rchy1)
PFLV: 114555332(rchy1)
GAT: 120831160(rchy1)
PPUG: 119225591(rchy1)
AFB: 129100776(rchy1)
CLUM: 117735930(rchy1)
PSWI: 130196564(rchy1)
MSAM: 119891134(rchy1)
SCHU: 122877074(rchy1)
CUD: 121510359(rchy1)
ALAT: 119020194(rchy1)
MZE: 101469895(rchy1)
ONL: 100709792(rchy1)
OAU: 116322684(rchy1)
OLA: 101158860(rchy1)
OML: 112148624(rchy1)
CSAI: 133451416(rchy1)
XMA: 102224741(rchy1)
XCO: 114155033(rchy1)
XHE: 116730185(rchy1)
PRET: 103469774(rchy1)
PFOR: 103146724(rchy1)
PLAI: 106940896(rchy1)
PMEI: 106909345(rchy1)
GAF: 122828860(rchy1)
PPRL: 129372996(rchy1)
CVG: 107098767(rchy1)
CTUL: 119775598(rchy1)
GMU: 124877352(rchy1)
NFU: 107393512(rchy1)
KMR: 108234884(rchy1)
ALIM: 106527487(rchy1)
NWH: 119414093(rchy1)
AOCE: 111583070(rchy1)
MCEP: 125011638(rchy1)
CSEM: 103397453(rchy1)
POV: 109633589(rchy1)
SSEN: 122769129(rchy1)
HHIP: 117768408(rchy1)
HSP: 118115509(rchy1)
PPLT: 128438119(rchy1)
SMAU: 118313370(rchy1)
LCF: 108878469
SDU: 111229511(rchy1)
SLAL: 111647870(rchy1)
XGL: 120805078(rchy1)
HCQ: 109525003(rchy1)
SSCV: 125993913
SBIA: 133499627(rchy1)
PEE: 133399485(rchy1)
PTAO: 133474710(rchy1)
BPEC: 110161063(rchy1)
MALB: 109954756(rchy1)
BSPL: 114862831(rchy1)
SJO: 128364597(rchy1)
STRU: 115164786 115199867(rchy1)
OTW: 112248299 112263145(rchy1)
OMY: 110525420(rchy1) 110535813
OGO: 124033380(rchy1) 124035157
OKE: 118358125 118392986(rchy1)
CCLU: 121550236(rchy1)
ELS: 105014503(rchy1)
SFM: 108938026(rchy1)
PKI: 111856628(rchy1)
AANG: 118206792(rchy1)
LOC: 102693872(rchy1)
PSPA: 121298654(rchy1)
PSEX: 120527441(rchy1)
LCM: 102350333(RCHY1)
CMK: 103177638(rchy1)
RTP: 109913221(rchy1)
CPLA: 122539263(rchy1)
HOC: 132833353(rchy1)
LERI: 129702442(rchy1)
PMRN: 116940365(RCHY1)
CIN: 100175171
SKO: 102806582
DME: Dmel_CG16947(Rchy1)
DER: 6540952
DSE: 6613628
DSI: Dsimw501_GD22576(Dsim_GD22576)
DSR: 110185041
DPO: 4818099
DPE: 6593562
DMN: 108163013
DWI: 6646711
DGR: 6561434
DAZ: 108611290
DNV: 115562952
DHE: 111603825
DVI: 6628738
RZE: 108378989
MDE: 101888446
SCAC: 106091993
LCQ: 111684042
GFS: 119640516
ECOE: 129941731
HIS: 119651997
AGA: 1280221
ACOZ: 120957072
AARA: 120900858
AMER: 121596449
ASTE: 118514638
AFUN: 125764590
AMOU: 128303278
AALI: 118456361
AAG: 5566806
ASUA: 134213132
CPII: 120418614
CNS: 116340666
BCOO: 119078605
AME: 408590
ACER: 108001789
ALAB: 122716759
ADR: 102675198
AFLR: 100863570
BIM: 100744260
BBIF: 117209084
BVK: 117233804
BVAN: 117160732
BTER: 100651326
BAFF: 126919406
BPYO: 122569363
BPAS: 132916246
FVI: 122534416
CCAL: 108628468
OBB: 114872358
OLG: 117603827
MGEN: 117228605
NMEA: 116425146
CGIG: 122395479
SOC: 105193458
MPHA: 105830617
AEC: 105151540
ACEP: 105619376
PBAR: 105430246
VEM: 105565208
HST: 105189834
DQU: 106749405
CFO: 105256036
FEX: 115233915
LHU: 105668561(Rchy1)
PGC: 109860547
OBO: 105280376
PCF: 106790920
PFUC: 122523443
VPS: 122630089
VCRB: 124425544
VVE: 124949355
NVI: 100115312
CSOL: 105359112
TPRE: 106650872
LHT: 122497956
LBD: 127282430
MDL: 103579673
CGLO: 123264757
AGIF: 122850157
CINS: 118067822
VCAN: 122407876
CCIN: 107265855
DSM: 124410296
NPT: 124219041
NFB: 124182492
NLO: 107217577
NVG: 124304696
AROA: 105690409
TCA: 662913
DPA: 109544958
SOY: 115882759
AGRG: 126735109
ATD: 109595561
CSET: 123307743
AGB: 108905945
DVV: 126892715
NVL: 108556985
APLN: 108737030
BMOR: 101743923
BMAN: 114240133
MSEX: 115452301
BANY: 112047073
MJU: 123875570
NIQ: 126774678
VCD: 124537397
MCIX: 123661526
PMAC: 106715731
PPOT: 106102523
PXU: 106114486
PRAP: 110996295
PBX: 123716237
PNAP: 125048564
ZCE: 119831856
CCRC: 123699020
AAGE: 121737196
HAW: 110380928
HZE: 124637944
TNL: 113505302
SLIU: 111349127
OFU: 114356510
ATRA: 106139340
GMW: 113509290
PXY: 105390710
PGW: 126374406
LGLY: 125234810
CFEL: 113368059
CCRN: 123299707
BTAB: 109034761
NLU: 111051119
HVI: 124355300
MQU: 128996446
FOC: 113211463
TPAL: 117643088
ZNE: 110835809
CSEC: 111870785
SGRE: 126271887
BROR: 134530831
IEL: 124157916
DMK: 116919445
DPZ: 124343320
PVM: 113809994
PCHN: 125043742
HAME: 121873042
PCLA: 123770356
CQD: 128703438
PTRU: 123515660
HAZT: 108680233
TCF: 131893289
DPTE: 113788382
PVUL: 126819553
BGT: 106079584
GAE: 121375787
HRF: 124141968
HRJ: 124275369
CRG: 105341692
MYI: 110443583
PMAX: 117320054
MCAF: 127734010
RPHI: 132719299
OBI: 106868636
OSN: 115215191
LJP: 135470526
LAK: 106165055
LLON: 135486994
AMIL: 114971457
HMG: 100203779
AQU: 100637302
APRO: F751_5421
ABE: ARB_02617
TVE: TRV_03034
DFA: DFA_09088
CPV: cgd1_2590
 » show all
Reference
  Authors
Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH
  Title
Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.
  Journal
J Biol Chem 286:4796-808 (2011)
DOI:10.1074/jbc.M110.157669
  Sequence
[hsa:25898]
Reference
  Authors
Corcoran CA, Montalbano J, Sun H, He Q, Huang Y, Sheikh MS
  Title
Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.
  Journal
J Biol Chem 284:21955-70 (2009)
DOI:10.1074/jbc.M109.024232
  Sequence
[hsa:25898]
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