KEGG Orthology (KO) - Caenorhabditis elegans (nematode)

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     KO
 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
   09151 Immune system
 
   09152 Endocrine system
 
   09153 Circulatory system
 
   09154 Digestive system
 
   09155 Excretory system
 
   09156 Nervous system
 
   09157 Sensory system
 
   09158 Development and regeneration
     04320 Dorso-ventral axis formation
     04360 Axon guidance
     04361 Axon regeneration [PATH:cel04361]
       CELE_C48A7.1 egl-19; Voltage-dependent L-type calcium channel subunit alpha
       CELE_F17C8.1 acy-1; adenylate cyclase
       CELE_ZK909.2 kin-1; cAMP-dependent protein kinase catalytic subunit
       CELE_C35D10.9 ced-4; Cell death protein 4
       CELE_C48D1.2 ced-3; Cell death protein 3 subunit p17
       CELE_C01B7.6 rpm-1; E3 ubiquitin-protein ligase rpm-1
       CELE_F07B7.12 rpms-1; PHR domain-containing protein
       CELE_F33E2.2 dlk-1; Mitogen-activated protein kinase kinase kinase dlk-1
       CELE_F42G10.2 mkk-4; MAP kinase kinase mkk-4
       CELE_VZC374L.1 sek-6; mitogen-activated protein kinase kinase
       CELE_ZC449.3 sek-3; mitogen-activated protein kinase kinase
       CELE_B0218.3 pmk-1; Mitogen-activated protein kinase pmk-1
       CELE_F42G8.3 pmk-2; Mitogen-activated protein kinase pmk-2
       CELE_F42G8.4 pmk-3; Protein kinase domain-containing protein
       CELE_C44C8.6 mak-2; MAP kinase-activated protein kinase mak-2
       CELE_F22A3.1 ets-4; Transcription factor ets-4
       CELE_D1005.3 cebp-1; CCAAT/enhancer-binding protein homolog 1
       CELE_T14E8.1 svh-2; Tyrosine-protein kinase receptor svh-2
       CELE_Y55D9A.1 efa-6; Exchange factor for Arf-6
       CELE_K11D9.1 klp-7; Kinesin-like protein
       CELE_EEED8.6 ccpp-6; Cytosolic carboxypeptidase 6
       CELE_C05B10.1 lip-1; Dual specificity protein phosphatase lip-1
       CELE_F08B1.1 vhp-1; Tyrosine-protein phosphatase vhp-1
       CELE_C07G1.1 svh-1; Serine protease svh-1
       CELE_K11D12.10 mlk-1; Mitogen-activated protein kinase kinase kinase mlk-1
       CELE_K08A8.1 mek-1; Dual specificity mitogen-activated protein kinase kinase mek-1
       CELE_B0478.1 jnk-1; Stress-activated protein kinase jnk-1
       CELE_T07A9.3 kgb-1; GLH-binding kinase 1
       CELE_ZC416.4 kgb-2; Stress-activated protein kinase JNK
       CELE_F29G9.4 fos-1; Transcription factor fos-1
       CELE_B0218.1 faah-1; Fatty acid amide hydrolase 1
       CELE_B0218.2 faah-2; Amidase domain-containing protein
       CELE_Y41C4A.2 faah-6; Amidase domain-containing protein
       CELE_Y56A3A.12 faah-4; Monoglyceride lipase faah-4
       CELE_C26C6.2 goa-1; Guanine nucleotide-binding protein G(o) subunit alpha
       CELE_E02C12.5 gpa-3; Guanine nucleotide-binding protein alpha-3 subunit
       CELE_F38E1.5 gpa-2; Guanine nucleotide-binding protein alpha-2 subunit
       CELE_M04C7.1 gpa-15; Guanine nucleotide-binding protein alpha-15 subunit
       CELE_R10H10.5 gpa-7; Guanine nucleotide-binding protein alpha-7 subunit
       CELE_T19C4.6 gpa-1; Guanine nucleotide-binding protein alpha-1 subunit
       CELE_M01D7.7 egl-30; Guanine nucleotide-binding protein subunit alpha
       CELE_B0348.4 egl-8; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
       CELE_B0545.1 tpa-1; Protein kinase C-like 1
       CELE_C09B7.1 ser-7; G-protein coupled receptors family 1 profile domain-containing protein
       CELE_R06A10.2 gsa-1; Guanine nucleotide-binding protein G(s) subunit alpha
       CELE_F18G5.3 gpa-12; Guanine nucleotide-binding protein alpha-12 subunit
       CELE_F13E6.6 rhgf-1; Guanine nucleotide exchange factor
       CELE_Y51H4A.3 rho-1; Ras-like GTP-binding protein rhoA
       CELE_C09E10.2 dgk-1; Diacylglycerol kinase
       CELE_F42A9.1 dgk-4; Diacylglycerol kinase
       CELE_F46H6.2 dgk-2; Diacylglycerol kinase
       CELE_F54G8.2 dgk-3; putative diacylglycerol kinase 3
       CELE_K06A1.6 dgk-5; Putative diacylglycerol kinase K06A1.6
       CELE_F38A6.3 hif-1; Hypoxia-inducible factor 1
       CELE_ZK1290.2 tph-1; Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
       CELE_C05D2.3 basl-1; Aromatic-L-amino-acid decarboxylase
       CELE_C05D2.4 bas-1; Aromatic-L-amino-acid decarboxylase
       CELE_Y55D5A.5 daf-2; Insulin-like receptor subunit beta
       CELE_B0334.8 age-1; Phosphatidylinositol 3-kinase age-1
       CELE_B0261.2 let-363; Target of rapamycin homolog
       CELE_T07A9.6 daf-18; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
       CELE_R13H8.1 daf-16; Forkhead box protein O
       CELE_F57C7.3 sdn-1; putative syndecan
       CELE_DY3.7 sup-17; Disintegrin and metalloproteinase domain-containing protein 10 homolog
       CELE_R107.8 lin-12; lin-12/Notch intracellular domain
       CELE_C18E3.8 hop-1; Presenilin hop-1
       CELE_F35H12.3 sel-12; Presenilin sel-12
       CELE_ZK524.1 spe-4; Presenilin spe-4
       CELE_R04A9.7 R04A9.7; Non-specific serine/threonine protein kinase
       CELE_Y47D3A.16 rsks-1; Ribosomal protein S6 kinase beta
       CELE_PAR2.3 aak-1; 5'-AMP-activated protein kinase catalytic subunit alpha-1
       CELE_T01C8.1 aak-2; 5'-AMP-activated protein kinase catalytic subunit alpha-2
       CELE_F40E10.4 slt-1; Slit homolog 1 protein
       CELE_M03A1.1 vab-1; Ephrin receptor 1
       CELE_ZK377.2 sax-3; Protein sax-3
       CELE_F41C6.1 unc-6; Netrin unc-6
       CELE_Y50D4C.1 unc-34; WH1 domain-containing protein
       CELE_F10E9.6 mig-10; Abnormal cell migration protein 10
       CELE_ZK470.5 nck-1; NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
       CELE_C09G12.8 ced-10; Ras-related protein ced-10
       CELE_C35C5.4 mig-2; Signal recognition particle protein
       CELE_K03D3.10 rac-2; Ras-related protein rac-2
       CELE_C05G5.6 let-7; microRNA let-7,b
       CELE_C12C8.3 lin-41; Protein lin-41
       CELE_F48F7.1 alg-1; Protein argonaute-2
       CELE_R09A1.1 ergo-1; Piwi-like protein ergo-1
       CELE_T07D3.7 alg-2; Protein argonaute-2
       CELE_W03C9.4 lin-29; Zinc finger transcription factor lin-29
K04851 CACNA1D; voltage-dependent calcium channel L type alpha-1D
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K20105 CED-4; cell death protein 4
K20106 CED-3; cell death protein 3
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K04422 MAP3K13; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K09442 SPDEF; SAM pointed domain-containing ETS transcription factor
K23479 CCAAT/enhancer binding protein (C/EBP), other
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K12494 PSD; PH and SEC7 domain-containing protein
K10393 KIF2_24; kinesin family member 2/24
K23439 AGBL4; cytosolic carboxypeptidase protein 6 [EC:3.4.17.24]
K04459 DUSP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
K04459 DUSP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
K23489 SVH1; HGF/MSP/plasminogen-like protein
K04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]
K04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09031 FOSLN; fos-like antigen, invertebrate
K15528 FAAH; fatty acid amide hydrolase [EC:3.5.1.99]
K15528 FAAH; fatty acid amide hydrolase [EC:3.5.1.99]
K15528 FAAH; fatty acid amide hydrolase [EC:3.5.1.99]
K15528 FAAH; fatty acid amide hydrolase [EC:3.5.1.99]
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K06068 PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
K04163 HTR7; 5-hydroxytryptamine receptor 7
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
K04513 RHOA; Ras homolog gene family, member A
K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K00502 TPH1_2; tryptophan 5-monooxygenase [EC:1.14.16.4]
K01593 DDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K01593 DDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K04527 INSR; insulin receptor [EC:2.7.10.1]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09408 FOXO3; forkhead box protein O3
K16336 SDC2; syndecan 2
K06704 ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]
K02599 NOTCH1; Notch 1
K04505 PSEN1; presenilin 1 [EC:3.4.23.-]
K04505 PSEN1; presenilin 1 [EC:3.4.23.-]
K04505 PSEN1; presenilin 1 [EC:3.4.23.-]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K06839 SLIT2; slit 2
K05110 EPHB1; Eph receptor B1 [EC:2.7.10.1]
K06754 ROBO2; roundabout, axon guidance receptor 2
K06843 NTN1; netrin 1
K23487 EVL; Ena/VASP-like protein
K23488 RAPH1; Ras-associated and pleckstrin homology domains-containing protein 1
K19862 NCK2; NCK adaptor protein 2
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K16980 MIRLET7; microRNA let-7
K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
K11593 ELF2C; eukaryotic translation initiation factor 2C
K11593 ELF2C; eukaryotic translation initiation factor 2C
K11593 ELF2C; eukaryotic translation initiation factor 2C
K23480 ZNF362_384; zinc finger protein 362/384
     04380 Osteoclast differentiation
     04382 Cornified envelope formation [PATH:cel04382]
 
   09149 Aging
 
   09159 Environmental adaptation
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
   09181 Protein families: metabolism
 
   09182 Protein families: genetic information processing
 
   09183 Protein families: signaling and cellular processes
     02000 Transporters [BR:cel02000]
     02044 Secretion system [BR:cel02044]
     02042 Bacterial toxins [BR:cel02042]
     02022 Two-component system
     02035 Bacterial motility proteins
     03037 Cilium and associated proteins [BR:cel03037]
     04812 Cytoskeleton proteins [BR:cel04812]
     04147 Exosome [BR:cel04147]
     02048 Prokaryotic defense system [BR:cel02048]
     04030 G protein-coupled receptors [BR:cel04030]
     04050 Cytokine receptors [BR:cel04050]
     04054 Pattern recognition receptors [BR:cel04054]
     03310 Nuclear receptors [BR:cel03310]
     04040 Ion channels [BR:cel04040]
     04031 GTP-binding proteins [BR:cel04031]
     04052 Cytokines and neuropeptides [BR:cel04052]
     04515 Cell adhesion molecules [BR:cel04515]
     04090 CD molecules [BR:cel04090]
     01504 Antimicrobial resistance genes
     00535 Proteoglycans [BR:cel00535]
     00536 Glycosaminoglycan binding proteins [BR:cel00536]
       CELE_T25F10.2 dbl-1; Protein dbl-1
       CELE_F38E1.7 mom-2; Protein mom-2
       CELE_K10B4.6 cwn-1; Protein Wnt-1
       CELE_W08D2.1 egl-20; Protein Wnt
       CELE_C05D11.4 let-756; Protein let-756
       CELE_F01G12.5 let-2; Collagen alpha-2(IV) chain
       CELE_F41C6.1 unc-6; Netrin unc-6
       CELE_F40E10.4 slt-1; Slit homolog 1 protein
       CELE_T22C8.2 chhy-1; Chondroitin hydrolase
       CELE_C42D8.8 apl-1; Amyloid-beta-like protein
       CELE_C25B8.3 cpr-6; Cathepsin B-like cysteine proteinase 6
       CELE_C52E4.1 cpr-1; Gut-specific cysteine proteinase
       CELE_F32H5.1 F32H5.1; Peptidase C1A papain C-terminal domain-containing protein
       CELE_F36D3.9 cpr-2; Peptidase C1A papain C-terminal domain-containing protein
       CELE_F44C4.3 cpr-4; Cathepsin B-like cysteine proteinase 4
       CELE_F57F5.1 cpr-9; Peptidase C1A papain C-terminal domain-containing protein
       CELE_T10H4.12 cpr-3; Cathepsin B-like cysteine proteinase 3
       CELE_W07B8.1 cpr-8; Peptidase C1A papain C-terminal domain-containing protein
       CELE_W07B8.4 W07B8.4; Peptidase C1A papain C-terminal domain-containing protein
       CELE_W07B8.5 cpr-5; Cathepsin B-like cysteine proteinase 5
       CELE_C10G8.5 ncx-2; Sodium/calcium exchanger membrane region domain-containing protein
       CELE_Y113G7A.4 ncx-1; Calx-beta domain-containing protein
       CELE_F59A2.3 cri-3; Conserved regulator of innate immunity protein 3
       CELE_W08F4.8 cdc-37; Hsp90 chaperone protein kinase-targeting subunit
K04662 BMP4; bone morphogenetic protein 4
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00408 WNT4; wingless-type MMTV integration site family, member 4
K01558 WNT16; wingless-type MMTV integration site family, member 16
K04358 FGF; fibroblast growth factor
K06237 COL4A; collagen type IV alpha
K06843 NTN1; netrin 1
K06839 SLIT2; slit 2
K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
K04520 APP; amyloid beta A4 protein
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger)
K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger)
K15414 C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial
K09554 CDC37; cell division cycle protein 37
     00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:cel00537]
     04091 Lectins [BR:cel04091]
     04990 Domain-containing proteins not elsewhere classified [BR:cel04990]
 
   09185 Viral protein families
 
   09184 RNA family
 
 09190 Not Included in Pathway or Brite

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Last updated: July 9, 2025