 Ubiquitins and ubiquitin-like proteins
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Ubiquitin-activating enzymes (E1)
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Ubiquitin-conjugating enzymes (E2)
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 Ubiquitin ligases (E3)
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HECT type E3
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 K10587 UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
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K10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]
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K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
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K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
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K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
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K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
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K05633 WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]
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K05630 WWP2, AIP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [EC:2.3.2.26]
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K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
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K10591 NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
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K13305 NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
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K10592 HUWE1, MULE, ARF-BP1, TOM1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
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K22370 AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1 [EC:2.3.2.26]
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K10593 EDD1, UBR5; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]
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K22371 G2H3; G2/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26]
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K10594 HERC1; E3 ubiquitin-protein ligase HERC1 [EC:2.3.2.26]
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K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
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K10614 HERC3; E3 ubiquitin-protein ligase HERC3 [EC:2.3.2.26]
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K10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]
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K12166 HACE1; E3 ubiquitin-protein ligase HACE1 [EC:2.3.2.26]
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K12167 HECW1; E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26]
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K12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
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K12231 HECTD1; E3 ubiquitin-protein ligase HECTD1 [EC:2.3.2.26]
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K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
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K12233 HECTD3; E3 ubiquitin-protein ligase HECTD3 [EC:2.3.2.26]
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K17849 HECTD4; E3 ubiquitin-protein ligase HECTD4 [EC:2.3.2.26]
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K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
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HECT type E3 associated proteins
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U-box type E3
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Single Ring-finger type E3
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BRE1 proteins
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CBL proteins
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SINA (Seven in absentia) proteins
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Ligand of Numb proteins
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March proteins
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MDM2/MDM4 proteins
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NFX1 proteins
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Pellino proteins
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Peripheral membrane proteins
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RBR proteins
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TRAF proteins
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TRIM/RBCC proteins
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UBR box proteins
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ATL proteins
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Other single Ring-finger type E3
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K10636 AMFR, GP78; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
K10603 AIRE; autoimmune regulator
K15684 BFAR; bifunctional apoptosis regulator
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
K10639 CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]
K10643 CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
K10606 FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K22376 KCMF1, FIGC; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K15686 MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
K10693 MYCBP2, PAM; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K10637 MYLIP, MIR; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K15689 NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27]
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27]
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10144 RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K10143 RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27]
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
K11980 RNF11; E3 ubiquitin-protein ligase RNF11
K16271 RLIM, RNF12; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K15692 RNF13, RZF; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
K10640 RNF25, AO7; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
K15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
K15694 RNF43; E3 ubiquitin-protein ligase RNF43 [EC:2.3.2.27]
K15695 RNF103, KF1; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27]
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
K25173 RNF112; E3 ubiquitin-protein ligase RNF112 [EC:2.3.2.27]
K15696 RNF113B; RING finger protein 113B
K15697 RNF114; E3 ubiquitin-protein ligase RNF114 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K15698 RNF121_175; RING finger protein 121/175
K15699 RNF122; RING finger protein 122
K12169 KPC1, RNF123; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K10629 RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]
K15701 RNF130, GOLIATH; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27]
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K15703 RNF139, TRC8; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
K23789 RNF145; E3 ubiquitin-protein ligase RNF145 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27]
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
K17821 RNF165; E3 ubiquitin-protein ligase RNF165 [EC:2.3.2.27]
K17044 RNF166; E3 ubiquitin-protein ligase RNF166 [EC:2.3.2.27]
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27]
K25214 RNF186; E3 ubiquitin-protein ligase RNF186 [EC:2.3.2.27]
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27]
K28516 RNFT2; E3 ubiquitin-protein ligase RNFT2
K11984 SART1, HAF, SNU66; U4/U6.U5 tri-snRNP-associated protein 1
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
K12171 SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K15711 SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
K10601 SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
K11985 TRAIP, TRIP; TRAF-interacting protein [EC:2.3.2.27]
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]
K10638 UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
K15713 UHRF2, NIRF; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27]
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
K15714 ZNF645; E3 ubiquitin-protein ligase ZNF645 [EC:2.3.2.27]
K25175 ZFP91; E3 ubiquitin-protein ligase ZFP91 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]
K15715 ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
K16274 AIP2; E3 ubiquitin-protein ligase AIP2 [EC:2.3.2.27]
K16275 BAH, NLA; E3 ubiquitin-protein ligase BAH [EC:2.3.2.27]
K19045 BB; E3 ubiquitin-protein ligase BIG BROTHER and related proteins [EC:2.3.2.27]
K16276 K16276, BTS; zinc finger protein-like protein
K19042 BOI; E3 ubiquitin-protein ligase BOI and related proteins [EC:2.3.2.27]
K16277 DRIP; E3 ubiquitin-protein ligase DRIP [EC:2.3.2.27]
K16278 HOS1; E3 ubiquitin-protein ligase HOS1 [EC:2.3.2.27]
K16279 KEG; E3 ubiquitin-protein ligase KEG [EC:2.7.11.1 2.3.2.27]
K16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]
K16281 RHA1; RING-H2 zinc finger protein RHA1
K16282 RHA2; E3 ubiquitin-protein ligase RHA2 [EC:2.3.2.27]
K19043 RHF; E3 ubiquitin-protein ligase RHF [EC:2.3.2.27]
K16283 SDIR1; E3 ubiquitin-protein ligase SDIR1 [EC:2.3.2.27]
K16284 SIS3; E3 ubiquitin-protein ligase SIS3 [EC:2.3.2.27]
K19044 XBAT32_33; E3 ubiquitin-protein ligase XBAT32/33 [EC:2.3.2.27]
K16285 XERICO; RING/U-box domain-containing protein [EC:2.3.2.27]
K16286 EL5; E3 ubiquitin-protein ligase EL5 [EC:2.3.2.27]
K23788 TUL1, FLY1_2; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
K25840 AIRP2; E3 ubiquitin-protein ligase AIRP2 [EC:2.3.2.27]
K27504 LOG2; E3 ubiquitin-protein ligase LOG2 [EC:2.3.2.27]
K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
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Atypical E3
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UBL E3 ligases
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Multi subunit type E3
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SCF complex
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Cul2 complex
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Ring finger protein
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Cullin
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Adoptor protein
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K03872 ELOC, TCEB1; elongin-C
K03873 ELOB, TCEB2; elongin-B
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Target recognizing subunit
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Cul3 complex
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Cul4 complex
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Ring finger protein
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Cullin
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Adoptor protein
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Target recognizing subunit (DCAF)
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K10140 DDB2; DNA damage-binding protein 2
K10570 ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8
K10571 DET1; de-etiolated-1
K10143 RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K11792 DDA1; DET1- and DDB1-associated protein 1
K11793 CRBN; cereblon
K11794 IFRG15; IFRG15 protein
K11796 TRPC4AP; Trpc4-associated protein
K11789 DCAF1, VPRBP; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]
K11790 DTL, CDT2, DCAF2; denticleless
K11799 DCAF4; DDB1- and CUL4-associated factor 4
K11800 DCAF5, BCRP2; DDB1- and CUL4-associated factor 5
K11795 DCAF6, IQWD1, NRIP, ARCAP; DDB1- and CUL4-associated factor 6
K11805 DCAF7, HAN11; DDB1- and CUL4-associated factor 7
K11804 DCAF8; DDB1- and CUL4-associated factor 8
K11807 WDTC1, DCAF9; WD and tetratricopeptide repeats protein 1
K11802 DCAF10; DDB1- and CUL4-associated factor 10
K11801 DCAF11; DDB1- and CUL4-associated factor 11
K11803 DCAF12; DDB1- and CUL4-associated factor 12
K11806 DCAF13, WDSOF1; DDB1- and CUL4-associated factor 13
K11797 PHIP, DCAF14; PH-interacting protein
K11791 DCAF15; DDB1- and CUL4-associated factor 15
K23626 DCAF16; DDB1- and CUL4-associated factor 16
K23331 DCAF17; DDB1- and CUL4-associated factor 17
K11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1/3
K22382 WDR26; WD repeat-containing protein 26
K24752 WDR70; WD repeat-containing protein 70
K24755 WDR76, CMR1; WD repeat-containing protein 76
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Cul5 complex
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Ring finger protein
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Cullin
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Adoptor protein
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K03872 ELOC, TCEB1; elongin-C
K03873 ELOB, TCEB2; elongin-B
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Target recognizing subunit
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Cul7 complex
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Cul8 complex
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Cul9 complex
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APC/C
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BRCC complex
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KPC complex
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LUBAC complex
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CTLH complex
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ERAD complex
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LMBR1L-GP78-UBAC2 complex
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STUB1-CHIC2 complex
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SLX5-SLX8 complex
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Multi subunit type E3 associated proteins
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Deubiquitinating enzyme (DUB)
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Ubiquitin System