KEGG   ORTHOLOGY: K04725
Entry
K04725                      KO                                     
Symbol
XIAP, BIRC4
Name
E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
Pathway
map01524  Platinum drug resistance
map04064  NF-kappa B signaling pathway
map04120  Ubiquitin mediated proteolysis
map04210  Apoptosis
map04214  Apoptosis - fly
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04510  Focal adhesion
map04621  NOD-like receptor signaling pathway
map04668  TNF signaling pathway
map05145  Toxoplasmosis
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05222  Small cell lung cancer
Disease
H00107  Other well-defined immunodeficiency syndromes
H01969  X-linked lymphoproliferative syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04668 TNF signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04214 Apoptosis - fly
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04215 Apoptosis - multiple species
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04217 Necroptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05207 Chemical carcinogenesis - receptor activation
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   03029 Mitochondrial biogenesis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I32: IAP family
   K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Retention of mitochondria
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Other DBs
GO: 0043027
Genes
HSA: 331(XIAP)
PTR: 473765(XIAP)
PPS: 100970113 100971253 100993738(XIAP)
GGO: 101127012 101133804(XIAP)
PON: 100449741(XIAP) 100937717
PPYG: 129024746(XIAP)
NLE: 100597865(XIAP)
HMH: 116479588 116484196(XIAP)
SSYN: 129475801(XIAP)
MCC: 698057(XIAP)
MCF: 102126399 102131393(XIAP)
MTHB: 126946702
MNI: 105468434(XIAP)
CSAB: 103247375(XIAP)
CATY: 105586304(XIAP) 105591186(BIRC8)
PANU: 100998457 101022825(XIAP)
TGE: 112605321(BIRC8) 112616539(XIAP)
MLEU: 105554881(XIAP)
RRO: 104655196(XIAP)
TFN: 117077500(XIAP)
PTEH: 111532918
CANG: 105508138(XIAP)
CJC: 100402341(XIAP)
SBQ: 101031174(XIAP)
CIMI: 108281831
ANAN: 105733139(XIAP)
CSYR: 103273297
MMUR: 105860713(XIAP)
LCAT: 123628616
PCOQ: 105826835(XIAP)
OGA: 100951522(XIAP)
MMU: 11798(Xiap)
MCAL: 110286671(Xiap)
MPAH: 110313538(Xiap)
RNO: 63879(Xiap)
MCOC: 116079101(Xiap)
ANU: 117694154(Xiap)
MUN: 110542115(Xiap)
CGE: 100689374(Xiap)
MAUA: 101824803
PROB: 127218100(Xiap)
PLEU: 114701517
MORG: 121439471
MFOT: 126486568
AAMP: 119804616
NGI: 103734850(Xiap)
HGL: 101715865(Xiap)
CPOC: 100715778(Xiap)
CCAN: 109700263(Xiap)
DORD: 105986903(Xiap)
DSP: 122109926
PLOP: 125343374
NCAR: 124972304
MMMA: 107152984
OCU: 100328700(XIAP) 100345253
OPI: 101530290
TUP: 102500839(XIAP)
GVR: 103608053(XIAP) 103610749
CFA: 442989(XIAP)
CLUD: 112649057
VVP: 112934433(XIAP)
VLG: 121482906
NPO: 129517703(XIAP)
AML: 100471203(XIAP)
UMR: 103680228
UAH: 113270927(XIAP)
UAR: 123792333
ELK: 111157209
LLV: 125091577
MPUF: 101671154(XIAP)
MNP: 132007612(XIAP)
MLK: 131822235(XIAP)
NVS: 122896474
ORO: 101367150(XIAP)
EJU: 114223713(XIAP)
ZCA: 113930311
MLX: 118012582(XIAP)
NSU: 110577355
LWW: 102746601(XIAP)
FCA: 101090594
PYU: 121025478
PCOO: 112870596(XIAP)
PBG: 122477723
PVIV: 125157223(XIAP)
LRUF: 124513901
PTG: 102957920(XIAP)
PPAD: 109250719(XIAP)
PUC: 125932285
AJU: 106972832
HHV: 120236173
BTA: 281647(XIAP)
BOM: 102275096(XIAP)
BBUB: 102404023
BBIS: 104984445
CHX: 102170035(XIAP)
OAS: 101116381(XIAP)
BTAX: 128070186(XIAP)
ODA: 120881497
CCAD: 122434599
MBEZ: 129564296(XIAP)
SSC: 100037300(XIAP)
CFR: 102507842(XIAP)
CBAI: 105075942(XIAP)
CDK: 105098886(XIAP)
VPC: 102540218(XIAP)
BACU: 103010212(XIAP)
BMUS: 118888493
LVE: 103085092(XIAP)
OOR: 101290359(XIAP)
DLE: 111168228(XIAP)
PCAD: 102978378(XIAP)
PSIU: 116747379(XIAP)
NASI: 112401089(XIAP)
ECB: 100060870(XIAP)
EPZ: 103543512(XIAP)
EAI: 106829909
MYB: 102246972(XIAP)
MYD: 102755332(XIAP)
MMYO: 118653756
MLF: 102436922(XIAP)
MDT: 132224354(XIAP)
PKL: 118722006
EFUS: 103301896(XIAP)
MNA: 107524984(XIAP)
DRO: 112310530(XIAP)
SHON: 119001606
AJM: 119055846
PDIC: 114504538
PHAS: 123827723
MMF: 118635819
PPAM: 129073352(XIAP)
HAI: 109390892(XIAP)
RFQ: 117021889(XIAP) 117029051
PALE: 102885349(XIAP)
PGIG: 120612220
PVP: 105304241(XIAP)
RAY: 107497750(XIAP)
MJV: 108391115
TOD: 119245919(XIAP)
SARA: 101549358(XIAP)
SETR: 125999096(XIAP)
LAV: 100657657(XIAP)
TMU: 101346318
ETF: 101662600
DNM: 101435770(XIAP)
MDO: 100016651(XIAP)
GAS: 123253493
SHR: 100928240(XIAP)
AFZ: 127543223
PCW: 110200954(XIAP)
TVP: 118832613
OAA: 100079889
GGA: 395280(XIAP)
PCOC: 116234903(XIAP)
MGP: 100542540(XIAP)
CJO: 107312953(XIAP)
TPAI: 128076243(XIAP)
LMUT: 125699651
NMEL: 110403244(XIAP)
APLA: 101796377
ACYG: 106038586(XIAP)
CATA: 118245486(XIAP)
AFUL: 116494556(XIAP)
TGU: 100231359(XIAP)
LSR: 110480473(XIAP)
SCAN: 103816388(XIAP)
PMOA: 120506206
OTC: 121331766
PRUF: 121363028
GFR: 102039585(XIAP)
FAB: 101819741(XIAP)
OMA: 130253075(XIAP)
PHI: 102101552(XIAP)
PMAJ: 107203935(XIAP)
CCAE: 111928676(XIAP)
CCW: 104694440
CBRC: 103621646(XIAP)
ETL: 114064797(XIAP)
ZAB: 102072646(XIAP)
ZLE: 135447999(XIAP)
ACHL: 103803462(XIAP)
SVG: 106859213(XIAP)
MMEA: 130573309(XIAP)
HRT: 120761969(XIAP)
SATI: 136370371(XIAP)
FPG: 101916449(XIAP)
FCH: 102051757(XIAP)
CCRI: 104169107(XIAP)
NNT: 104409037
SHAB: 115612638(XIAP)
ACUN: 113480037(XIAP)
TALA: 104368652
ACHC: 115333630
HALD: 104319745
HLE: 104832679(XIAP)
AGEN: 126050339
GCL: 127019489
CSTI: 104553172
LDI: 104342532
MNB: 103780543
DPUB: 104299555(XIAP)
AVIT: 104267071(XIAP)
BRHI: 104488620(XIAP)
EGZ: 104124100(XIAP)
NNI: 104023425(XIAP)
PCRI: 104026276
PCAO: 104052143(XIAP)
PADL: 103922595(XIAP)
AFOR: 103895639(XIAP)
FGA: 104083647(XIAP)
GSTE: 104257348(XIAP)
CLV: 102088054(XIAP)
MUI: 104537250(XIAP)
PGUU: 104468931(XIAP)
PLET: 104617739(XIAP)
EHS: 104515627(XIAP)
CMAC: 104477815
CUCA: 104068501(XIAP)
TEO: 104371198(XIAP)
BREG: 104641708(XIAP)
OHA: 104339073(XIAP)
ACAR: 104525946
CPEA: 104388277(XIAP)
CVF: 104290206(XIAP)
RTD: 128914776(XIAP)
AAM: 106487581(XIAP)
AROW: 112977305(XIAP)
NPD: 112944519(XIAP)
TGT: 104578694(XIAP)
DNE: 112997207(XIAP)
SCAM: 104150010(XIAP)
ASN: 102386593(XIAP)
AMJ: 102570735(XIAP)
CPOO: 109313567(XIAP)
GGN: 109300765(XIAP)
PSS: 102449987(XIAP)
CMY: 102939941
CCAY: 125642440
DCC: 119861110
CPIC: 101937031
TST: 117882841(XIAP)
CABI: 116830438(XIAP)
MRV: 120372466
ACS: 100557644(xiap)
ASAO: 132763055(XIAP)
PVT: 110088616(XIAP)
SUND: 121936807
PBI: 103053668(XIAP)
PMUR: 107297409(XIAP)
CTIG: 120313572
PGUT: 117665131(XIAP)
APRI: 131204905(XIAP)
PTEX: 113437784(XIAP)
NSS: 113416733(XIAP)
VKO: 123022051
PMUA: 114589070(XIAP)
PRAF: 128406368(XIAP)
ZVI: 118084167(XIAP)
HCG: 128335667(XIAP)
GJA: 107123686(XIAP)
STOW: 125442974
EMC: 129341717(XIAP)
XLA: 733235(xiap.L)
XTR: 594971(xiap)
NPR: 108788768(XIAP)
RTEM: 120913744
BBUF: 120977195
BGAR: 122946169
MUO: 115474611(XIAP)
GSH: 117360730(XIAP)
DRE: 373108(xiap)
SRX: 107751921(xiap)
SANH: 107666595 107670164
SGH: 107561284 107600151
CCAR: 109053945
CAUA: 113057722 113073486 113114190
CGIB: 127971868 128027301
PTET: 122358298
LROH: 127176082
OMC: 131553879(xiap)
PPRM: 120460625
RKG: 130075600(xiap)
MAMB: 125259069
CIDE: 127525703
CERY: 137020368(xiap)
MASI: 127413464 127418382
TROS: 130563400(xiap)
TDW: 130437911(xiap)
MANU: 129422959(xiap)
IPU: 108269205(xiap) 108269206
IFU: 128611436(xiap) 128611437
PHYP: 113529366(xiap)
SMEO: 124385791
TFD: 113636052
TVC: 132856199(xiap)
TRN: 134319629(xiap)
AMEX: 103037921
CMAO: 118806894
EEE: 113581375(xiap)
CHAR: 105912626
TRU: 101067395
TFS: 130531145(xiap)
LCO: 104938662(xiap)
TBEN: 117474974(xiap)
CGOB: 115014252(xiap)
PGEO: 117454071(xiap)
GACU: 117550753(xiap)
EMAC: 134859884(xiap)
ELY: 117260567(xiap)
EFO: 125894584
PLEP: 121947947
SLUC: 116036580
ECRA: 117952036(xiap)
ESP: 116697435(xiap)
PFLV: 114563007(xiap)
GAT: 120818475
PPUG: 119210105
AFB: 129090163(xiap)
CLUM: 117737091(xiap)
PSWI: 130210120(xiap)
MSAM: 119889051
SCHU: 122880699
CUD: 121515941
ALAT: 119007067
MZE: 101472383
ONL: 100702537(xiap)
OAU: 116315168
OLA: 101166883
OML: 112153690
CSAI: 133447221(xiap)
XMA: 102236946
XCO: 114139667
XHE: 116714306
PRET: 103470906(xiap)
PFOR: 103139935
PLAI: 106964079
PMEI: 106905144
GAF: 122837308
PPRL: 129362905(xiap)
CTUL: 119790477
GMU: 124859842
NFU: 107384738(xiap)
KMR: 108237932
NWH: 119409119
AOCE: 111583181(xiap)
MCEP: 125007958
CSEM: 103391373
POV: 109647059(xiap)
SSEN: 122778630
HHIP: 117769083(xiap)
HSP: 118111884
PPLT: 128446428(xiap)
SMAU: 118319500
LCF: 108882775
SDU: 111226606(xiap)
SLAL: 111646416(xiap)
XGL: 120785816
HCQ: 109524245
SSCV: 125978272
SBIA: 133509110(xiap)
PEE: 133407309(xiap)
PTAO: 133484417(xiap)
BPEC: 110158118(xiap)
MALB: 109955160 109957605(xiap)
BSPL: 114863939(xiap)
SJO: 128362945(xiap)
SASA: 106604301 106612162(BIRC4)
STRU: 115168034 115205647
OTW: 112236582(xiap) 112255900
OMY: 110489126 110504588
OGO: 123994181 124011389
ONE: 115117826 115118688
OKI: 109878610 109879194
OKE: 118363234 118375490
SALP: 111965995 112072521
SNH: 120035023 120062411
CCLU: 121536486 121539527
ELS: 105024403(xiap)
SFM: 108925196
PKI: 111853545(xiap)
AANG: 118224103(xiap)
LOC: 102684651(xiap)
PSPA: 121295567 121318906
ARUT: 117430831
PSEX: 120537398
LCM: 102349446(XIAP)
CMK: 103178709
RTP: 109919537
CPLA: 122557310
HOC: 132820159
LERI: 129702043
PMRN: 116946028
LRJ: 133340383
BBEL: 109485374
CIN: 100177446 100186811 778999(zf(ring)-22)
SCLV: 120340420 120340432 120348578
BBIF: 117208559 117208617
BVAN: 117155953
BAFF: 126928325
BPAS: 132910532 132910555 132910558 132910559 132910560 132910561 132915322 132915325
FEX: 115241113
PFUC: 122526293
AGIF: 122850505 122850929
DVV: 126892008 126892652
API: 100159652
ACOO: 126847165
DVT: 126896767
PJA: 122263241
PCHN: 125028178
PCLA: 123748919 123751302 123752032
EAF: 111699210
VDE: 111245273
VJA: 111269460
DFR: 124498803
PMEO: 129580953 129582276 129599475 129600348
PVUL: 126810912 126812264 130014372
BGT: 106051851 106051852 106052414 106052415 106061051 106061668 106062822 106067757 106069078 106069084 106072706 106075258 106076635
GAE: 121374247
HRF: 124110479 124138656 124145217 124145218 124145219 124145222
HRJ: 124272640 124280562 124289649 124291512
CRG: 109617982 117680425
CANU: 128184003 128184297 128186236
CVN: 111103826
OED: 125669747
MYI: 110457948
PMAX: 117326848 117327439 117328058
MMER: 123546992 123552322 123552754 123556198 123556213
RPHI: 132754670
DPOL: 127849559
MAEA: 128221918 128222366 128237408 128238166 128238233 128238291
LJP: 135466538 135472205
LAK: 106161698
 » show all
Reference
PMID:8654366
  Authors
Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM, Thompson CB
  Title
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
  Journal
EMBO J 15:2685-94 (1996)
DOI:10.1002/j.1460-2075.1996.tb00629.x
  Sequence
[hsa:331]
Reference
PMID:12121969
  Authors
MacFarlane M, Merrison W, Bratton SB, Cohen GM
  Title
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
  Journal
J Biol Chem 277:36611-6 (2002)
DOI:10.1074/jbc.M200317200
  Sequence
[hsa:331]
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