KEGG image  Cancer-associated Carbohydrates

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N-glycan

Glycan Structure Gene Cancer Type PubMed
beta1,6-GlcNAc branch G10818 G10818 MGAT5 Colorectal cancer [DS:H00020]
Non-small cell lung cancer [DS:H00014]
Bladder cancers [DS:H00022]
Glioma [DS:H00042]
Breast cancer [DS:H00031]		 32890705
10815896
1985789
25727152
10646865
30143259
Bisecting GlcNAc G00019 G00019 MGAT3 Liver cancer [DS:H00048] 25727145
2523254
Core fucose G00016 G00016 FUT8 Liver cancer [DS:H00048]
Breast cancer [DS:H00031]
Colorectal cancer [DS:H00020]
Ovarian cancer [DS:H00027]
Non-small cell lung cancer [DS:H00014]
Prostate cancer [DS:H00024]
Thyroid cancer [DS:H00032]
Melanoma [DS:H00038]
Pancreatic cancer [DS:H00019]		 33466384
alpha2,6-Sialylation ST6GAL1 Colorectal cancer [DS:H00020]
Pancreatic cancer [DS:H00019]
Prostate cancer [DS:H00024]
Breast cancer [DS:H00031]
Ovarian cancer [DS:H00027]		 31423157
11425186

Truncated Mucin-type O-glycan

Glycan Structure Gene Cancer Type PubMed
Tn
CD175		 G00023 G00023 C1GALT1 Breast cancer [DS:H00031]
Colorectal cancer [DS:H00020]
Lung cancer [DS:H00013 H00014]
Bladder cancer [DS:H00022]
Cervical cancer [DS:H00030]
Ovarian cancer[DS:H00027]
Stomach cancer [DS:H00018]
Prostate cancer [DS:H00024]		 27679419
21964054
Sialyl Tn (sTn)
CD175s		 G00035 G00035 ST6GALNAC1 Breast cancer [DS:H00031]
Colorectal cancer [DS:H00020]
Lung cancer [DS:H00013 H00014]
Bladder cancer [DS:H00022]
Cervical cancer [DS:H00030]
Ovarian cancer [DS:H00027]
Stomach cancer [DS:H00018]
Prostate cancer [DS:H00024]		 27679419
Thomsen-Friedenreich (T, TF) G00024 G00024 GCNT1 Breast cancer [DS:H00031]
Colorectal cancer [DS:H00020]
Bladder cancer [DS:H00022]
Prostate cancer [DS:H00024]
Liver cancer [DS:H00048]
Stomach cancer [DS:H00018]		 27679419
Sialyl T (sT) G00026 G00026 ST3GAL1 Breast cancer [DS:H00031]
Prostate cancer [DS:H00024]
Bladder cancer [DS:H00022]		 32583304
19811634
25142811

Lewis / Cad antigen

Glycan Structure Gene Cancer Type PubMed
Ley
CD174		 G00256 G00256 FUT1
FUT4		 Ovarian cancer [DS:H00027]
Breast cancer [DS:H00031]
Prostate cancer [DS:H00024]
Colorectal cancer [DS:H00020]
Non-small cell lung cancer [DS:H00014]
Embryonal carcinomas [DS:H00023 H00027]
Yolk sac tumors [DS:H00023]
Seminomas [DS:H00023]		 21964054
28586014
Leb G00263 G00263 FUT1
FUT2		 Colorectal cancer [DS:H00020]
Breast cancer [DS:H00031]		 10336994
1651804
SLex
CA15-3		 G00242 G00242 ST3GAL3
ST3GAL4
ST3GAL6
FUT3
FUT4
FUT6
FUT7		 Breast cancer [DS:H00031]
Ovarian cancer [DS:H00027]
Melanoma [DS:H00038]
Colorectal cancer [DS:H00020]
Liver cancer [DS:H00048]
Non-small cell lung cancer [DS:H00014]
Prostate cancer [DS:H00024]
Gastric cancer [DS:H00018]
Pancreatic cancer [DS:H00019]		 21964054
9711529
9106690
9276710
10739688
23726834
SLea
CA19-9		 G00257 G00257 ST3GAL3
FUT3		 Breast cancer [DS:H00031]
Colorectal cancer [DS:H00020]
Pancreatic cancer [DS:H00019]
Melanoma [DS:H00038]		 12362971
21964054
Lex
SSEA-1		 G00243 G00243 FUT3
FUT4
FUT9
B3GNT5		 Colorectal cancer [DS:H00020]
Stomach cancer [DS:H00018]
Uterine cancer [DS:H00026]
Breast cancer [DS:H00031]
Ovarian cancer [DS:H00027]
Kidney carcinomas [DS:H00021]
Transtitional cell carcinomas [DS:H00022]
Acute myeloid leukemia (AML) [DS:H00003]
Bladder cancer [DS:H00022]
Glioma [DS:H00042]
Renal cell carcinoma [DS:H00021]
Pancreatic cancer [DS:H00019]		 12362971
19427293
35526049
2880658
2405185
3335015
SLec G00825 G00825 ST3GAL6 Pancreas cancer [DS:H00019]
Gastrointestinal cancer [DS:H00018 H00020]		 3457770
1931612
Cad G01357 G01357 Liver cancer [DS:H00048] 2167157

Glycosphingolipid

Glycan Structure Gene Cancer Type PubMed
Gb3
CD77		 G00093 G00093 A4GALT Breast cancer [DS:H00031]
Ovarian cancer [DS:H00027]
Haematological malignancies [DS:H00004 H00005]
Astrocytoma tumors [DS:H00042]
Colorectal cancer [DS:H00020]
Gastric cancer [DS:H00018]
Non-small cell lung cancer [DS:H00014]
Pancreatic cancer [DS:H00019]		 12227795
19714252
26826119
Forssman G00095 G00095 GBGT1 Gastric cancer [DS:H00018]
Colon cancer [DS:H00020]
Lung cancers [DS:H00013 H00014]		 6257673
7512587
Globo H G00099 G00099 FUT1
FUT2		 Breast cancer [DS:H00031]
Prostate cancer [DS:H00024]
Lung cancer [DS:H00013 H00014]
Colorectal cancer [DS:H00020]
Gastric cancer [DS:H00018]
Pancreatic cancer [DS:H00019]
Ovarian cancer [DS:H00027]
Endometrial cancer [DS:H00026]		 12227795
6501317
2481353
21964054
SSEA-3
Gb5		 G00097 G00097 B3GALT5 Testicular cancer[DS:H00023]
Lung cancer[DS:H00013 H00014]
Breast cancer[DS:H00031]
Teratocarcinoma [DS:H00023 H00027]
Colorectal cancer [DS:H00020]		 12227795
2837767
21964054
26677875
SSEA-4
Sialy-Gb5		 G00098 G00098 ST3GAL2 Breast cancer [DS:H00031]
Prostate cancer [DS:H00024]
Epithelial ovarian carcinoma [DS:H00027]
Renal cell carcinoma [DS:H00021]
Oral cancer [DS:H00016]
Glioblastoma multiforme [DS:H00042]
Teratocarcinoma [DS:H00023 H00027]		 10775053
25978997
Disialosyl-Gb5 G00181 G00181 ST6GALNAC6 Renal cell carcinoma [DS:H00021]
Hepatocellular carcinoma [DS:H00048]
Colorectal cancer [DS:H00020]
Teratocarcinoma [DS:H00023 H00027]		 7509790
11278988
22808038
GalNAc disialosyl Lc4Cer G00189 G00189 Renal cell carcinoma [DS:H00021] 11278988
Asialo-GM1 G00124 G00124 B3GALT4 Prostate cancer [DS:H00024]
Breast cancer [DS:H00031]		 19724904
25384497
Fucosyl-GM1 G00166 G00166 ST3GAL5
B4GALNT1
B3GALT4
FUT1
FUT2		 Small-cell lung cancer [DS:H00013] 1851663
21964054
GD1alpha G00127 G00127 ST6GALNAC5 Breast cancer [DS:H00031] 25913930
19421193
27529215
GD1a G00111 G00111 ST3GAL2 Prostate cancer [DS:H00024] 21165949
GD3 G00113 G00113 ST8SIA1 Melanoma [DS:H00038]
Glioma [DS:H00042]
Neuroblastoma [DS:H00043]
Breast cancer [DS:H00031]		 7130176
12818424
23479608
21964054
27304202
9-O-Ac-GD3
CD60b		 G00169 G00169 ST8SIA1 Malignant melanomas [DS:H00038]
Basal cell carcinomas [DS:H00039]
Breast cancer [DS:H00031]		 3339003
9749956
9-O-Ac-GT3 G00170 G00170 ST8SIA1 Breast cancer [DS:H00031] 12374193
GD2 G00114 G00114 ST8SIA1
B4GALNT1		 Melanoma [DS:H00038]
Glioma [DS:H00042]
Neuroblastoma cells [DS:H00043]
Small-cell lung cancer [DS:H00013]
Breast cancer [DS:H00031]
Ewing sarcoma [DS:H00035]
Osteosarcoma [DS:H00036]
Retinoblastoma [DS:H01513]		 6296843
21964054
23479608
28154831
29436609
27304202
22585577
22374462
24166473
33898999
9-O-Ac-GD2 G00183 G00183 Neuroblastoma [DS:H00043]
Small cell lung cancer [DS:H00013]
Melanoma [DS:H00038]
Glioma [DS:H00042]
Breast cancer [DS:H00031]		 28154831
1644805
37670947
GM3 G00108 G00108 ST3GAL5 Acute myeloid leukemia (AML) [DS:H00003]
Ovarian cancer [DS:H00027]
Prostate cancer [DS:H00024]		 21964054
de-N-Ac-GM3 G00593 G00593 Melanoma [DS:H00038] 19903858
NeuGcGM3 G00258 G00258 Colorectal cancer [DS:H00020]
Breast cancer [DS:H00031]
Melanoma [DS:H00038]
Non-small cell lung cancer [DS:H00014]
Neuroblastoma [DS:H00043]
Germ cell tumors [DS:H00023 H00027]		 21964054
25420897
28604556
25085576
GM2 G00109 G00109 ST3GAL5
B4GALNT1		 Melanoma [DS:H00038]
Glioma [DS:H00042]
Neuroblastoma cells [DS:H00043]
Gastroinestinal cancer [DS:H00018 H00020]
Small cell lung cancer [DS:H00013]		 2479468
7533654
21964054
21895875
Lc3 G00036 G00036 B3GNT5 Acute myeloid leukemia (AML) [DS:H00003] 22411838
Sialylparagloboside (SPG) G00062 G00062 ST3GAL6 Prostate cancer [DS:H00024] 2960671
21165949
Disialyl Lea G01148 G01148 ST6GALNAC6 Colorectal cancer [DS:H00020] 12668675
Dimeric Lea G01153 G01153 Colorectal cancer [DS:H00020]
Gastric cancer [DS:H00018]		 2022659
9703902
Dimeric Lex G00090 G00090 Colorectal cancer [DS:H00020] 2960671
Trifucosyl-Leb
Leb/Lea hybrid		 G01843 G01843 Colorectal cancer [DS:H00020]
Liver cancer [DS:H00048]
Pancreatic cancer [DS:H00019]
Endometrial cancer [DS:H00026]		 1735443
1377598
nLc4 G00050 G00050 B3GNT5 Acute myeloid leukemia (AML) [DS:H00003] 2960671
22411838
P1 G00428 G00428 Ovarian cancer [DS:H00027] 25167227
Lea/Lex hybrid G01154 G01154 Human squamous lung cancer [DS:H00014]
Testicular cancer [DS:H00023]		 2450645
7521211
Trifucosyl-Ley
Ley/Lex hybrid		 G00082 G00082 Colorectal cancer [DS:H00020]
Liver cancer [DS:H00048]
Pancreatic cancer [DS:H00019]
Endometrial cancer [DS:H00026]		 3733752
2426269
1377598

Other

Glycan Structure Gene Cancer Type PubMed
Polysialic acid (PSA) G13065 G13065 ST8SIA2
ST8SIA4		 Small cell lung carcer [DS:H00013]
Non-small cell lung [DS:H00014]
Rhabdomyosarcoma [DS:H00037]
Wilms' tumor
Neuroblastoma glioblastoma multiforme [DS:H00042]
Medulloblastoma [DS:H01667]
Glioma [DS:H00042]
 25373518

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Last updated: December 12, 2023