KEGG   PATHWAY: aamp05022
Entry
aamp05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Arvicola amphibius (Eurasian water vole)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
aamp05022  Pathways of neurodegeneration - multiple diseases
aamp05022

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119825083  amyloid-beta precursor protein isoform X1 [KO:K04520]
119812136  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
119807720  Snca; alpha-synuclein isoform X1 [KO:K04528]
119817660  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
119812907  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
119823612  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
119824833  Fus; RNA-binding protein FUS isoform X1 [KO:K13098]
119825355  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
119819330  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
119825576  Atxn2; ataxin-2 isoform X1 [KO:K23625]
119813545  Atxn2l; ataxin-2-like protein isoform X1 [KO:K23625]
119800776  Htt; huntingtin isoform X1 [KO:K04533]
119802127  Atxn1l; ataxin-1-like [KO:K23616]
119816215  Atxn1; ataxin-1 [KO:K23616]
119818629  Atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
119814701  major prion protein [KO:K05634]
119799823  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
119816034  Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
119815576  Chrm5; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5 [KO:K04133]
119817270  Sptbn2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
119821203  Grm1; metabotropic glutamate receptor 1 [KO:K04603]
119802846  Grm5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
119812597  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119820894  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
119814344  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814366  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814933  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
119824882  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119814207  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119820784  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119826609  Trpc3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
119826711  Sigmar1; sigma non-opioid intracellular receptor 1 [KO:K20719]
119806390  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119806213  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119823109  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119820756  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
119817089  Ryr2; ryanodine receptor 2 [KO:K04962]
119815223  Ryr3; ryanodine receptor 3 [KO:K04963]
119813983  Pdyn; proenkephalin-B [KO:K15840]
119811175  Dlg4; disks large homolog 4 isoform X1 [KO:K11828]
119818834  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119812911  Grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
119806515  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
119812477  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
119802465  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
119811934  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
119826282  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
119804703  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
119809558  Gria4; LOW QUALITY PROTEIN: glutamate receptor 4 [KO:K05200]
119818472  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119806908  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119828004  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119804579  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119827234  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
119825645  Stx1a; syntaxin-1A isoform X1 [KO:K04560]
119802858  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
119824551  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119826284  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119813074  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119818546  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
119827510  Psen2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
119822534  Derl1; derlin-1 [KO:K11519]
119826416  transitional endoplasmic reticulum ATPase [KO:K13525]
119807910  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119827772  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119801833  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
119826235  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119813257  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
119820410  ubiquitin-like isoform X1 [KO:K02927]
119807985  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119822323  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119822363  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
119820601  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119812055  Ubb; polyubiquitin-B [KO:K08770]
119825557  Ubc; polyubiquitin-C [KO:K08770]
119819422  Psma6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
119806930  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
119816961  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
119810264  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
119826499  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
119814848  Psma8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
119814251  Psma7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
119800933  Psma5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
119826314  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
119807368  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
119818710  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
119811925  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
119818701  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
119808982  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119804953  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119805275  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
119812338  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
119799913  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
119817964  Psmb2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
119800066  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
119821027  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
119801014  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
119826096  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7-like [KO:K03061]
119803931  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
119819347  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
119821340  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
119800168  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
119814467  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
119817394  26S proteasome regulatory subunit 8-like [KO:K03066]
119811765  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
119825492  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
119820512  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
119812910  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
119825311  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
119813232  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
119812065  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
119828047  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
119802238  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
119808239  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
119800726  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
119812782  26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
119818979  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
119820678  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
119814373  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
119815375  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
119800351  Uchl1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
119804691  Uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
119810582  Uba7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
119807808  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
119807847  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
119808384  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
119802572  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
119825384  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
119826856  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
119819090  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
119817566  Ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
119826232  Ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
119822433  Ube2g2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
119811223  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
119808477  Gpr37; prosaposin receptor GPR37 [KO:K04243]
119824778  Septin5; septin-5 isoform X1 [KO:K04557]
119814737  synphilin-1 isoform X1 [KO:K04558]
119818639  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
119814346  Vapb; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
119827727  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
119803285  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
119811524  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
119812025  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
119818726  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119820587  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119824883  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119820456  Map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
119808167  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119818610  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119822546  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119810258  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
119816504  Pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
119815378  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119821089  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119823492  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119804764  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119814379  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119808469  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
119821547  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119822367  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119816292  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119817139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119800371  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119808111  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119803343  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119813558  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119807886  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119810302  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
119822816  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119815606  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119825491  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
119819937  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119807526  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119821505  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
119810151  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
119827973  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
119808788  acyl carrier protein, mitochondrial-like [KO:K03955]
119812443  acyl carrier protein, mitochondrial-like [KO:K03955]
119807454  acyl carrier protein, mitochondrial [KO:K03955]
119810775  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119811058  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
119803407  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119813692  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119818574  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
119800598  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
119806913  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
119804078  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119825606  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119825940  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
119825963  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
119801780  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119811753  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
119823332  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119812927  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119804641  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119804932  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119820696  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119827486  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119814166  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119810090  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119809107  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119803219  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810541  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119816982  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119818379  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119825922  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810417  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119821308  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119814511  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119826441  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119802653  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
119809157  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119816786  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119827624  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
119809004  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119816634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119822897  cytochrome c1, heme protein, mitochondrial [KO:K00413]
119810716  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
119818376  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119817782  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119823100  cytochrome b-c1 complex subunit 7 [KO:K00417]
119826150  cytochrome b-c1 complex subunit 7 [KO:K00417]
119812643  cytochrome b-c1 complex subunit 8 [KO:K00418]
119822943  cytochrome b-c1 complex subunit 10 [KO:K00420]
119824516  cytochrome b-c1 complex subunit 10-like [KO:K00420]
119801810  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119815669  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119808969  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119820956  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119800700  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119823348  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119824540  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119813186  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119826874  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119821317  cytochrome c oxidase subunit 6B2 [KO:K02267]
119803616  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119812348  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119820632  cytochrome c oxidase subunit 6B1 [KO:K02267]
119823502  cytochrome c oxidase subunit 6C-2 [KO:K02268]
119804134  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
119808129  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119821387  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
119810497  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119820589  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
119821824  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119824561  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119804752  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119807117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
119818750  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119809813  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119824069  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119822805  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119818361  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
119806473  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
119814908  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119803617  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119801085  ATP synthase subunit gamma, mitochondrial [KO:K02136]
119816174  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119821561  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
119814896  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
119800757  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119807929  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119827952  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119822775  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119818833  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119812397  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
119826216  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119807061  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119817869  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
119812417  Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
119824792  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
119825399  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119813406  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119824693  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
119827718  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119821075  Tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
119827627  Tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518]
119823855  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
119821021  Calm3; calmodulin-3 [KO:K02183]
119808332  Calm2; calmodulin-2 [KO:K02183]
119808754  Calml4; calmodulin-like protein 4 [KO:K02183]
119809106  calmodulin-1 [KO:K02183]
119815477  calmodulin-1 [KO:K02183]
119817551  Calml3; calmodulin-like protein 3 [KO:K02183]
119817552  calmodulin-4-like [KO:K02183]
119818370  Calm1; calmodulin-1 [KO:K02183]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119823615  Lrrk2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
119806736  Htra2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
119812627  Trap1; LOW QUALITY PROTEIN: heat shock protein 75 kDa, mitochondrial [KO:K09488]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119827941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119803346  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119825181  Hip1; LOW QUALITY PROTEIN: huntingtin-interacting protein 1 [KO:K04559]
119825289  Ift57; intraflagellar transport protein 57 homolog [KO:K04638]
119804867  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
119819446  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
119826784  Ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
119817006  Park7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
119815691  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
119826377  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
119816725  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
119816810  Optn; LOW QUALITY PROTEIN: optineurin [KO:K19946]
119812500  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
119808221  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
119815781  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
119802123  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119821180  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
119819470  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
119810257  Wdr41; WD repeat-containing protein 41 [KO:K23610]
119813354  Smcr8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
119826656  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
119813322  Rab8a; ras-related protein Rab-8A [KO:K07901]
119805138  Rab39b; ras-related protein Rab-39B [KO:K07925]
119810099  Rab1a; ras-related protein Rab-1A [KO:K07874]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119824755  Ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
119811830  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
119823995  Atg101; autophagy-related protein 101 [KO:K19730]
119814258  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
119826166  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
119814136  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
119812489  Becn1; beclin-1 [KO:K08334]
119808826  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
119800037  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
119823226  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
119815605  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
119802023  Atg2a; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog A [KO:K17906]
119818581  Atg2b; autophagy-related protein 2 homolog B [KO:K17906]
119824978  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
119812957  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
119818541  Zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
119803789  Als2; alsin isoform X1 [KO:K04575]
119822397  Rab5a; ras-related protein Rab-5A [KO:K07887]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119824939  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
119821524  Fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
119814727  Spg11; spatacsin [KO:K19026]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119817843  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
119822854  Daxx; death domain-associated protein 6 [KO:K02308]
119813155  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119812035  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119824418  Nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
119813671  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
119810199  Gpx8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
119810492  Gpx1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
119817076  Gpx7; glutathione peroxidase 7 isoform X1 [KO:K00432] [EC:1.11.1.9]
119817581  Gpx5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
119817662  Gpx6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
119812831  Gpx3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
119820000  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
119815810  Cat; catalase [KO:K03781] [EC:1.11.1.6]
119823179  Prph; peripherin isoform X1 [KO:K07607]
119800460  Nefl; neurofilament light polypeptide [KO:K04572]
119800487  Nefm; neurofilament medium polypeptide [KO:K04573]
119805981  Nefh; neurofilament heavy polypeptide [KO:K04574]
119816354  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
119803441  Kif5a; kinesin heavy chain isoform X1 [KO:K10396]
119819571  Kif5c; kinesin heavy chain [KO:K10396]
119822629  Klc4; kinesin light chain 4 [KO:K10407]
119819630  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
119827138  Klc2; kinesin light chain 2 [KO:K10407]
119820796  Klc3; kinesin light chain 3 isoform X1 [KO:K10407]
119821363  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
119822305  tubulin alpha-1B chain [KO:K07374]
119822381  Tuba1a; tubulin alpha-1A chain [KO:K07374]
119822383  tubulin alpha-1C chain [KO:K07374]
119817489  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
119805855  tubulin alpha-3 chain [KO:K07374]
119806400  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119806404  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119806674  Tuba8; tubulin alpha-8 chain [KO:K07374]
119814720  Tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
119801749  uncharacterized protein LOC119801749 [KO:K07375]
119816178  tubulin beta-2B chain [KO:K07375]
119823163  Tubb; tubulin beta chain [KO:K07375]
119819107  Tubb4b; tubulin beta-4B chain [KO:K07375]
119825449  Tubb4a; tubulin beta-4A chain [KO:K07375]
119814018  Tubb6; tubulin beta-6 chain [KO:K07375]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119802199  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
119814096  Csnk2a1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
119822509  Csnk2b; casein kinase II subunit beta [KO:K03115]
119815449  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
119806959  Dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
119803284  Dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
119826325  Dctn3; dynactin subunit 3 [KO:K10425]
119814483  Dctn4; dynactin subunit 4 [KO:K10426]
119799732  Dctn5; dynactin subunit 5 [KO:K10427]
119813426  Dctn6; dynactin subunit 6 [KO:K10428]
119823268  Actr1b; beta-centractin [KO:K16575]
119825732  Actr1a; alpha-centractin isoform X1 [KO:K16575]
119818650  Actr10; actin-related protein 10 [KO:K16576]
119812923  Hap1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
119827712  Dnah14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
119809772  Dnah5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
119822799  Dnah8; dynein heavy chain 8, axonemal [KO:K10408]
119811011  Dnah9; dynein heavy chain 9, axonemal [KO:K10408]
119803918  Dnah7; dynein heavy chain 7, axonemal [KO:K10408]
119811465  Dnah2; LOW QUALITY PROTEIN: dynein heavy chain 2, axonemal [KO:K10408]
119811772  Dnah17; dynein heavy chain 17, axonemal [KO:K10408]
119818684  Dnah11; dynein heavy chain 11, axonemal [KO:K10408]
119825317  Dnah3; dynein heavy chain 3, axonemal isoform X2 [KO:K10408]
119825327  Dnah10; dynein heavy chain 10, axonemal [KO:K10408]
119807016  Dnah6; dynein heavy chain 6, axonemal [KO:K10408]
119827424  Dnah1; LOW QUALITY PROTEIN: dynein heavy chain 1, axonemal [KO:K10408]
119827549  Dnah12; dynein heavy chain 12, axonemal [KO:K10408]
119817553  Dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
119826060  Dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
119811135  Dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
119819242  Dnal1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
119822860  Dnal4; dynein light chain 4, axonemal [KO:K10412]
119800462  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119800784  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
119808786  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119814221  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
119827467  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
119799550  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
119813642  Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
119806641  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
119804312  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
119801474  Dkk2; dickkopf-related protein 2 [KO:K02165]
119811063  Dkk4; dickkopf-related protein 4 [KO:K02165]
119805949  Dkk1; dickkopf-related protein 1 [KO:K02165]
119824043  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
119801133  Wnt2b; protein Wnt-2b [KO:K00182]
119807630  Wnt2; protein Wnt-2 [KO:K00182]
119813159  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
119817378  Wnt4; protein Wnt-4 [KO:K00408]
119827774  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
119808280  Wnt5b; protein Wnt-5b [KO:K00444]
119821641  Wnt6; protein Wnt-6 [KO:K00445]
119808152  Wnt7a; protein Wnt-7a [KO:K00572]
119823832  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
119801469  Wnt8b; protein Wnt-8b [KO:K00714]
119815317  Wnt8a; protein Wnt-8a [KO:K00714]
119812884  Wnt9b; protein Wnt-9b [KO:K01064]
119813175  Wnt9a; protein Wnt-9a [KO:K01064]
119821609  Wnt10a; protein Wnt-10a [KO:K01357]
119823873  Wnt10b; protein Wnt-10b [KO:K01357]
119802903  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
119808392  Wnt16; protein Wnt-16 [KO:K01558]
119803883  Fzd7; frizzled-7 [KO:K02432]
119803894  Fzd1; frizzled-1 [KO:K02432]
119813185  Fzd2; frizzled-2 [KO:K02235]
119800348  Fzd3; frizzled-3 [KO:K02329]
119802675  Fzd4; frizzled-4 [KO:K02354]
119802282  Fzd8; frizzled-8 [KO:K02375]
119820296  Fzd5; frizzled-5 [KO:K02375]
119822803  Fzd6; frizzled-6 [KO:K02376]
119825464  Fzd9; frizzled-9 [KO:K02842]
119825673  Fzd10; frizzled-10 [KO:K02842]
119825088  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
119806598  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
119822771  Csnk1e; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
119816593  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
119811174  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
119824840  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
119822495  Frat1; proto-oncogene FRAT1 [KO:K03069]
119822724  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
119813237  Axin1; axin-1 isoform X1 [KO:K02157]
119813003  Axin2; axin-2 [KO:K04385]
119800867  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
119815778  Apc; adenomatous polyposis coli protein [KO:K02085]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119814283  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
119822474  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119805132  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119805194  Nox1; NADPH oxidase 1 [KO:K08008]
119805427  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
119802703  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119811441  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
119827843  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
119808459  Il6; interleukin-6 [KO:K05405]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119814887  Il1b; interleukin-1 beta [KO:K04519]
119801389  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Reference
PMID:28062563
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Dugger BN, Dickson DW
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Pathology of Neurodegenerative Diseases.
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Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
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Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
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Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
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Ross CA, Poirier MA
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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Reference
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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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Reference
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Dantuma NP, Bott LC
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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
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Reference
PMID:25413678
  Authors
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Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
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Reference
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Int J Mol Sci 21:E3369 (2020)
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Reference
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
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Mol Brain 12:100 (2019)
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Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
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Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
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Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Reference
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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
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Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
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Halliday M, Hughes D, Mallucci GR
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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Axonal transport deficits and neurodegenerative diseases.
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Axonal transport and neurological disease.
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Retrograde axonal transport: pathways to cell death?
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Related
pathway
aamp00190  Oxidative phosphorylation
aamp03050  Proteasome
aamp04020  Calcium signaling pathway
aamp04120  Ubiquitin mediated proteolysis
aamp04137  Mitophagy - animal
aamp04140  Autophagy - animal
aamp04141  Protein processing in endoplasmic reticulum
aamp04142  Lysosome
aamp04210  Apoptosis
aamp04310  Wnt signaling pathway
aamp04724  Glutamatergic synapse
aamp04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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