KEGG   PATHWAY: dcc04010
Entry
dcc04010                    Pathway                                
Name
MAPK signaling pathway - Dermochelys coriacea (leatherback sea turtle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dcc04010  MAPK signaling pathway
dcc04010

Other DBs
GO: 0000165
Organism
Dermochelys coriacea (leatherback sea turtle) [GN:dcc]
Gene
119845817  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
119844125  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X3 [KO:K04849]
119848353  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119858685  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
119859930  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
119847431  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119842835  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
119862363  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
119845061  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
119846310  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
119841581  CACNA2D1; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
119859072  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
119859443  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
119856304  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
119849071  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
119851382  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
119845765  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
119863607  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
119843180  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
119863546  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
119862013  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
119843256  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
119843411  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
119847384  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
119847180  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
119846853  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
119845833  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
119845780  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
119845878  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
119860147  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
119842981  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
119862602  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119847377  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119862577  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
119860791  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119845753  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
119854590  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119848644  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
119858624  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119853301  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
119862070  RASGRF1; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
119856106  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
119857950  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
119858970  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
119853954  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
119847262  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
119854506  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
119844489  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
119855483  RASA1; ras GTPase-activating protein 1 [KO:K04352]
119861029  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
119846364  RAP1A; ras-related protein Rap-1A [KO:K04353]
119859043  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
119855290  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119848797  TGFA; protransforming growth factor alpha [KO:K08774]
119854965  EREG; proepiregulin [KO:K09784]
119854964  AREG; amphiregulin [KO:K09782]
119860187  FGF1; fibroblast growth factor 1 [KO:K18496]
119854425  FGF2; fibroblast growth factor 2 [KO:K18497]
119860285  FGF18; fibroblast growth factor 18 [KO:K04358]
119854456  FGF20; fibroblast growth factor 20 [KO:K04358]
119854808  fibroblast growth factor 18-like isoform X1 [KO:K04358]
119854929  FGF5; fibroblast growth factor 5 [KO:K04358]
119855385  FGF10; fibroblast growth factor 10 [KO:K04358]
119861568  FGF16; fibroblast growth factor 16 [KO:K04358]
119848526  FGF22; fibroblast growth factor 22 [KO:K04358]
119848700  FGF17; fibroblast growth factor 17 [KO:K04358]
119862622  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
119849947  FGF9; fibroblast growth factor 9 isoform X2 [KO:K04358]
119857646  FGF3; fibroblast growth factor 3 [KO:K04358]
119857775  FGF4; fibroblast growth factor 4 [KO:K04358]
119858860  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119843968  FGF6; fibroblast growth factor 6 [KO:K04358]
119857577  FGF19; fibroblast growth factor 19 [KO:K22603]
119847345  FGF21; fibroblast growth factor 21 [KO:K22429]
119863807  FGF23; fibroblast growth factor 23 [KO:K22428]
119846409  NGF; beta-nerve growth factor [KO:K02582]
119857383  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
119861590  NTF3; neurotrophin-3 [KO:K04356]
119847319  NTF4; neurotrophin-4 [KO:K12457]
119857525  insulin-like [KO:K04526]
119863689  IGF1; insulin-like growth factor I [KO:K05459]
119857315  IGF2; insulin-like growth factor II [KO:K13769]
119863047  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119850043  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
119849934  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
119855275  PDGFC; platelet-derived growth factor C [KO:K05450]
119846278  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119861925  KITLG; kit ligand [KO:K05461]
119853253  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
119859115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K05448]
119847257  snake venom vascular endothelial growth factor toxin ICPP-like isoform X1 [KO:K16859]
119857620  PGF; placenta growth factor [KO:K16859]
119854696  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
119855730  VEGFD; vascular endothelial growth factor D [KO:K05449]
119860386  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
119851317  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122455377  angiopoietin-2-like isoform X1 [KO:K05466]
119853908  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
119842378  ANGPT4; angiopoietin-4 [KO:K05467]
119847803  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
119847822  EFNA3; ephrin-A3 [KO:K05462]
119848069  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
119848223  ephrin-A2-like [KO:K05462]
119856151  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
119855384  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119848413  NRTN; neurturin [KO:K25414]
119860178  ARTN; artemin [KO:K25415]
119845648  PSPN; persephin [KO:K25416]
119851699  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119849062  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119845664  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119863480  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
119848596  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
119858475  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
119854594  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
119860434  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119849179  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119851422  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
119847779  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
119855704  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119848198  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
119862152  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119854364  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119860427  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
119859838  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
119854727  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
119850618  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
119861605  vascular endothelial growth factor receptor kdr-like isoform X2 [KO:K05096] [EC:2.7.10.1]
119844953  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
119860492  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
119855034  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119848506  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119855619  angiopoietin-1 receptor isoform X3 [KO:K05121] [EC:2.7.10.1]
119845100  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119859399  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X3 [KO:K05126] [EC:2.7.10.1]
119842878  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
119857021  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119853924  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119857099  HRAS; GTPase HRas [KO:K02833]
119854719  KRAS; GTPase KRas isoform X1 [KO:K07827]
119847080  GTPase HRas-like [KO:K07827]
119846218  NRAS; GTPase NRas [KO:K07828]
119847224  RRAS; ras-related protein R-Ras [KO:K07830]
119857343  LOW QUALITY PROTEIN: ras-related protein R-Ras-like [KO:K07830]
119857912  RRAS2; ras-related protein R-Ras2 [KO:K07830]
119863797  MRAS; ras-related protein M-Ras [KO:K07831]
119847238  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
119849953  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
119858193  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119862496  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119848307  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119854422  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
119843641  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119857894  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
119848224  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
119860092  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
119861801  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
119845468  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119853449  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
119854351  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119847686  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119847159  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
119846282  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
119852135  MYC; myc proto-oncogene protein [KO:K04377]
119853419  SRF; serum response factor [KO:K04378]
119857951  FOS; proto-oncogene c-Fos [KO:K04379]
119849155  MAPT; microtubule-associated protein tau isoform X3 [KO:K04380]
119845561  STMN1; stathmin [KO:K04381]
119860755  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
119841585  cytosolic phospholipase A2 gamma-like isoform X4 [KO:K16342] [EC:3.1.1.4]
119857233  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
119857450  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
119842223  LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
119858047  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
119857319  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
119857318  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
119857376  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
119857320  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
119857322  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
119842931  TNF; tumor necrosis factor [KO:K03156]
119848666  interleukin-1 beta-like [KO:K04519]
119848579  interleukin-1 beta-like [KO:K04519]
119847152  TGFB1; LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375]
119854030  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
119857859  TGFB3; transforming growth factor beta-3 proprotein isoform X2 [KO:K13377]
119849982  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119852824  interleukin-1 receptor type 1 isoform X2 [KO:K04386]
119851624  LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K04386]
119861236  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
119850901  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
119851479  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119863153  LOW QUALITY PROTEIN: TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
119860555  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119858224  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
119862255  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119846632  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119842977  RAC3; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 3 [KO:K07861]
119845005  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119841019  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119854273  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119842911  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
119844349  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
119842563  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
119851837  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119847060  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119852920  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119856996  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
119848502  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
119855877  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
119860113  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
119859541  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
119852884  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
119845791  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
119853925  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
119861530  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
119854359  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
119847499  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
119858443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119861238  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
119841823  STK4; serine/threonine-protein kinase 4 [KO:K04411]
119851727  STK3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
119859122  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
119852255  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
119855899  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
119863684  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
119849034  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X2 [KO:K04421] [EC:2.7.11.25]
119851757  mitogen-activated protein kinase kinase kinase 3-like isoform X2 [KO:K04421] [EC:2.7.11.25]
119857575  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
119854020  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
119846138  MAP3K12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
119861384  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
119863592  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
119845314  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
119853200  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
119852837  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119853138  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
119843949  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
119857082  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
119844517  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
119842738  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
119845784  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X5 [KO:K04431] [EC:2.7.12.2]
119862777  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
119842822  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
119856953  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
119860162  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
119862297  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
119847066  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
119843596  CRKL; LOW QUALITY PROTEIN: crk-like protein [KO:K04438]
119844496  CRK; adapter molecule crk isoform X1 [KO:K04438]
119849297  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
119856859  ARRB1; beta-arrestin-1 isoform X2 [KO:K04439]
119854416  MAPK10; mitogen-activated protein kinase 10 isoform X6 [KO:K04440] [EC:2.7.11.24]
119858546  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119859742  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
119852713  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119852721  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119846308  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119846510  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119843710  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
119846462  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
119859300  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
119857150  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
119859143  RPS6KA4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
119854970  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
119852225  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119841060  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119860735  JUN; transcription factor AP-1 [KO:K04448]
119848343  JUND; transcription factor jun-D [KO:K04449]
119863210  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X8 [KO:K04450]
119849273  TP53; cellular tumor antigen p53 [KO:K04451]
119846108  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
119857757  MAX; protein max isoform X1 [KO:K04453]
119855514  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
119844442  HSPB1; heat shock protein beta-1 [KO:K04455]
119847363  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119856834  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119853376  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119856723  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
119847234  PPM1N; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
119859395  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
119857972  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
119846383  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
119860669  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
119855166  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119848707  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119857934  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119850110  DUSP16; LOW QUALITY PROTEIN: dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119859185  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119859453  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119850211  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
119847467  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
119858825  dual specificity protein phosphatase 10-like isoform X2 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
119853693  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
119849055  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
119847112  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
119852770  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
119847633  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
119847862  heat shock 70 kDa protein 1A-like [KO:K03283]
119846639  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
119861367  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
119862666  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
119856779  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
119846065  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119849083  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119858630  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119848740  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
119847100  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119844563  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
119854760  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
119858836  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X4 [KO:K04469]
119858230  RELA; transcription factor p65 isoform X1 [KO:K04735]
119847121  RELB; transcription factor RelB isoform X3 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dcc04070  Phosphatidylinositol signaling system
dcc04110  Cell cycle
dcc04115  p53 signaling pathway
dcc04210  Apoptosis
dcc04310  Wnt signaling pathway
KO pathway
ko04010   
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