KEGG   PATHWAY: dro04010
Entry
dro04010                    Pathway                                
Name
MAPK signaling pathway - Desmodus rotundus (common vampire bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dro04010  MAPK signaling pathway
dro04010

Other DBs
GO: 0000165
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112301443  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112306604  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112309331  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112301160  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112296834  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112322357  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112316206  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
112322024  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112318756  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112303467  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
112309612  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
112301237  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
112300270  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
112316240  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
112318863  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112318438  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
112312991  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
112316564  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112321939  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
112304840  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
112316539  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
112316445  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112321291  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
112321284  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
112321273  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112319524  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
112301587  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112309207  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112305449  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112317863  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112305248  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112297858  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112304508  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112305987  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
112307470  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
112311978  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
112317389  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
112297824  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
112320197  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
112312369  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112308507  NF1; neurofibromin isoform X1 [KO:K08052]
112307544  RASA1; ras GTPase-activating protein 1 [KO:K04352]
112301113  RASA2; ras GTPase-activating protein 2 [KO:K08053]
112313714  RAP1A; ras-related protein Rap-1A [KO:K04353]
112318977  RAP1B; ras-related protein Rap-1b [KO:K07836]
112296254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112303034  TGFA; protransforming growth factor alpha [KO:K08774]
112320476  AREG; amphiregulin [KO:K09782]
112318067  FGF1; fibroblast growth factor 1 [KO:K18496]
112312217  FGF2; fibroblast growth factor 2 [KO:K18497]
112302323  FGF6; fibroblast growth factor 6 [KO:K04358]
112305225  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112319711  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112311746  FGF7; fibroblast growth factor 7 [KO:K04358]
112323185  FGF9; fibroblast growth factor 9 [KO:K04358]
112315295  FGF10; LOW QUALITY PROTEIN: fibroblast growth factor 10 [KO:K04358]
112319696  FGF18; fibroblast growth factor 18 [KO:K04358]
112306790  FGF20; fibroblast growth factor 20 [KO:K04358]
112312291  FGF22; fibroblast growth factor 22 [KO:K04358]
112317958  FGF16; LOW QUALITY PROTEIN: fibroblast growth factor 16 [KO:K04358]
112317419  FGF4; fibroblast growth factor 4 [KO:K04358]
112317420  FGF3; fibroblast growth factor 3 [KO:K04358]
112300468  fibroblast growth factor 8-like [KO:K04358]
112317418  FGF19; fibroblast growth factor 19 [KO:K22603]
112310055  FGF21; fibroblast growth factor 21 [KO:K22429]
112306914  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
112313781  NGF; beta-nerve growth factor [KO:K02582]
112303343  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112321936  NTF3; neurotrophin-3 [KO:K04356]
112310216  NTF4; neurotrophin-4 [KO:K12457]
112321846  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112317267  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112319719  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112321825  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112314347  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112312671  PDGFC; platelet-derived growth factor C [KO:K05450]
112313968  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
112315389  KITLG; kit ligand isoform X1 [KO:K05461]
112310213  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
112302143  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112317384  VEGFB; vascular endothelial growth factor B [KO:K16858]
112311551  PGF; placenta growth factor [KO:K16859]
112306665  VEGFC; vascular endothelial growth factor C [KO:K05449]
112313412  VEGFD; vascular endothelial growth factor D [KO:K05449]
112301961  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112315503  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112321314  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112304242  ANGPT4; angiopoietin-4 [KO:K05467]
112316763  EFNA1; ephrin-A1 [KO:K05462]
112314348  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
112312180  EFNA2; ephrin-A2 [KO:K05462]
112307205  EFNA5; ephrin-A5 [KO:K05462]
112315548  EFNA3; ephrin-A3 [KO:K05462]
112321122  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112312601  NRTN; neurturin [KO:K25414]
112314450  ARTN; artemin [KO:K25415]
112312214  PSPN; persephin [KO:K25416]
112306912  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112316215  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112319025  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112307700  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
112306733  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112300272  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112320339  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112316485  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112315668  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112304477  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112296365  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112306076  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112316918  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112319577  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112319552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112316812  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112323198  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
112323117  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112300051  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
112296393  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112316796  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112300421  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112302877  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112299135  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
112305517  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112298645  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112297971  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112310995  SOS2; son of sevenless homolog 2 [KO:K03099]
112317099  HRAS; GTPase HRas isoform X1 [KO:K02833]
112318275  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
112304041  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
112313707  NRAS; GTPase NRas [KO:K07828]
112310162  RRAS; ras-related protein R-Ras [KO:K07829]
112303376  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112309967  MRAS; ras-related protein M-Ras [KO:K07831]
112322484  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112299790  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112317797  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112312431  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
112314555  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
112313403  RPS6KA3; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
112315102  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
112297421  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
112299247  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112321682  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112322485  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112318083  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
112315592  MYC; myc proto-oncogene protein [KO:K04377]
112302098  SRF; serum response factor [KO:K04378]
112311412  FOS; proto-oncogene c-Fos [KO:K04379]
112316173  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
112299484  STMN1; stathmin [KO:K04381]
112296687  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
112311060  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112311538  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112311539  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
112302067  TNF; tumor necrosis factor isoform X1 [KO:K03156]
112303128  IL1A; interleukin-1 alpha [KO:K04383]
112302944  IL1B; interleukin-1 beta [KO:K04519]
112320009  TGFB1; transforming growth factor beta-1 [KO:K13375]
112318906  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112311221  TGFB3; transforming growth factor beta-3 [KO:K13377]
112321955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112315147  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
112301004  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
112304528  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112309970  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112297049  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112307358  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112318027  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112321719  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112298813  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112299195  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112300831  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112306749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112306448  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112302087  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
112309628  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112296346  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112318391  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112303407  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
112312410  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112307265  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112312272  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
112309280  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112322023  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112297111  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112301542  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
112297970  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
112315227  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
112320124  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
112316047  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
112320635  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112303982  STK4; serine/threonine-protein kinase 4 [KO:K04411]
112315573  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
112317276  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
112316842  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112315269  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
112317244  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
112313010  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
112316249  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
112311900  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
112320192  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
112306103  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
112318252  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
112308163  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
112305730  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
112299262  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
112297079  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112296959  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112297294  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
112304761  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
112308944  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
112310381  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
112308830  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
112305131  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112308621  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112316519  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112303417  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
112321659  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
112298286  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
112296269  FLNA; filamin-A isoform X1 [KO:K04437]
112301790  CRKL; crk-like protein [KO:K04438]
112308445  CRK; adapter molecule crk isoform X1 [KO:K04438]
112315831  ARRB1; beta-arrestin-1 [KO:K04439]
112308595  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
112296379  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112305558  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112317841  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112302047  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112321896  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112302140  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112322057  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
112310875  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
112318256  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
112309920  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
112311411  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
112317082  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
112304072  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112322654  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
112300806  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112314642  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112305027  JUND; transcription factor jun-D [KO:K04449]
112305718  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112308825  TP53; cellular tumor antigen p53 [KO:K04451]
112319047  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112311197  MAX; protein max isoform X1 [KO:K04453]
112307451  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
112314926  HSPB1; heat shock protein beta-1 [KO:K04455]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112311154  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
112318985  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
112303383  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
112318892  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
112319677  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
112318672  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112319413  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112309704  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112317435  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112306719  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112300453  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112315297  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
112296305  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
112318760  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
112298590  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
112312882  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
112297955  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
112301823  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
112302142  heat shock 70 kDa protein 1 [KO:K03283]
112302152  heat shock 70 kDa protein 1-like [KO:K03283]
112307202  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
112311249  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
112308530  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
112318469  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112298609  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112300474  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112296261  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112308929  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112300178  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
112317202  RELA; transcription factor p65 [KO:K04735]
112312895  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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PMID:12947395
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
dro04070  Phosphatidylinositol signaling system
dro04110  Cell cycle
dro04115  p53 signaling pathway
dro04210  Apoptosis
dro04310  Wnt signaling pathway
dro04668  TNF signaling pathway
KO pathway
ko04010   
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