KEGG   PATHWAY: dsp04010
Entry
dsp04010                    Pathway                                
Name
MAPK signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dsp04010  MAPK signaling pathway
dsp04010

Other DBs
GO: 0000165
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122100293  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
122101285  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
122108123  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
122103755  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122098776  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122101283  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122123782  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
122123617  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
122126705  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122111799  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
122095552  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
122108012  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
122102546  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
122103511  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122113099  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
122106361  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
122110846  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
122094975  Cacng1; voltage-dependent calcium channel gamma-1 subunit isoform X1 [KO:K04866]
122110569  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
122119286  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
122116183  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122094950  Cacng4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
122094956  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122110699  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122110697  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122110693  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
122104508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122119798  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122128350  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122116145  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122110671  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
122113573  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
122104327  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122127053  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122096621  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122116547  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122110513  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
122122799  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
122123393  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122117332  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122114558  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
122104915  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122102090  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122097593  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
122097797  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122117803  Nf1; neurofibromin isoform X1 [KO:K08052]
122117115  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
122095267  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122104391  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
122124042  Rap1b; ras-related protein Rap-1b [KO:K07836]
122127051  Egf; pro-epidermal growth factor [KO:K04357]
122125176  Tgfa; protransforming growth factor alpha [KO:K08774]
122106918  Ereg; proepiregulin [KO:K09784]
122106898  Areg; amphiregulin [KO:K09782]
122118224  Fgf1; fibroblast growth factor 1 [KO:K18496]
122119078  Fgf2; fibroblast growth factor 2 [KO:K18497]
122127554  Fgf20; fibroblast growth factor 20 [KO:K04358]
122096618  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122112831  Fgf9; fibroblast growth factor 9 [KO:K04358]
122097662  Fgf16; fibroblast growth factor 16 [KO:K04358]
122106885  Fgf5; fibroblast growth factor 5 [KO:K04358]
122114692  Fgf7; fibroblast growth factor 7 [KO:K04358]
122122838  Fgf22; fibroblast growth factor 22 [KO:K04358]
122099887  Fgf3; fibroblast growth factor 3 [KO:K04358]
122115956  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122101870  Fgf18; fibroblast growth factor 18 [KO:K04358]
122117016  Fgf10; fibroblast growth factor 10 [KO:K04358]
122102809  Fgf6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
122125586  Fgf21; fibroblast growth factor 21 [KO:K22429]
122102807  Fgf23; fibroblast growth factor 23 [KO:K22428]
122118375  Ngf; beta-nerve growth factor [KO:K02582]
122117755  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122102605  Ntf3; neurotrophin-3 [KO:K04356]
122125884  Ntf4; neurotrophin-4 [KO:K12457]
122102073  Ins; insulin [KO:K04526]
122119198  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122102070  Igf2; insulin-like growth factor II [KO:K13769]
122113621  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122123581  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
122104212  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122097855  Pdgfc; platelet-derived growth factor C [KO:K05450]
122109178  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122119178  Kitlg; kit ligand isoform X1 [KO:K05461]
122125712  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122101493  Vegfa; vascular endothelial growth factor A [KO:K05448]
122104926  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
122118724  Pgf; placenta growth factor isoform X1 [KO:K16859]
122108520  Vegfd; vascular endothelial growth factor D [KO:K05449]
122126084  Vegfc; vascular endothelial growth factor C [KO:K05449]
122111940  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
122102398  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
122125262  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
122120328  Angpt4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
122122829  Efna2; ephrin-A2 [KO:K05462]
122109403  Efna1; ephrin-A1 [KO:K05462]
122109474  Efna3; ephrin-A3 isoform X1 [KO:K05462]
122109523  Efna4; ephrin-A4 isoform X1 [KO:K05462]
122118247  Efna5; ephrin-A5 isoform X1 [KO:K05462]
122116981  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
122122866  Nrtn; neurturin [KO:K25414]
122109468  Artn; artemin isoform X1 [KO:K25415]
122122760  Pspn; persephin [KO:K25416]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122103204  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122124201  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
122107486  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
122107616  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122126852  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122100692  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122096494  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122103503  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122109658  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122122111  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122119565  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122123999  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122106871  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122118168  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122118243  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122106872  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122112631  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122096363  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122112548  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122115490  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122106648  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122121823  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122121294  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122099158  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122122245  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122124495  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
122128376  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
122104519  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122106484  Sos2; son of sevenless homolog 2 [KO:K03099]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122118367  Nras; GTPase NRas [KO:K07828]
122125793  Rras; ras-related protein R-Ras [KO:K07829]
122117759  Rras2; ras-related protein R-Ras2 [KO:K07830]
122095273  Mras; ras-related protein M-Ras [KO:K07831]
122098764  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122105936  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122127184  Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
122108204  ragulator complex protein LAMTOR3-like [KO:K04370]
122117272  ragulator complex protein LAMTOR3-like [KO:K04370]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122122681  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
122110290  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
122098116  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122115205  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122100111  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122116083  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
122123666  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122098786  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
122109722  Elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
122102408  Myc; myc proto-oncogene protein [KO:K04377]
122101565  Srf; serum response factor [KO:K04378]
122118881  Fos; proto-oncogene c-Fos [KO:K04379]
122103501  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
122118971  stathmin-like [KO:K04381]
122115296  Stmn1; stathmin [KO:K04381]
122117489  stathmin-like isoform X1 [KO:K04381]
122103830  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122114427  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
122114429  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122114610  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
122114616  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
122125680  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
122111281  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
122100603  Il1a; interleukin-1 alpha [KO:K04383]
122100606  Il1b; interleukin-1 beta [KO:K04519]
122097410  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
122109464  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122118877  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
122102541  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122121295  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
122098975  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
122121204  Tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
122096026  Tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122103807  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122116005  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122118142  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
122113510  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122119204  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122099403  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122119115  cell division control protein 42 homolog [KO:K04393]
122115178  Cdc42; cell division control protein 42 homolog [KO:K04393]
122126138  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122126104  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122099715  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122111402  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
122096770  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122097062  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
122106144  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
122117775  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
122104319  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122113654  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122099301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122123572  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
122102982  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122119821  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
122104521  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122121383  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122097396  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
122115583  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122097055  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122120207  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
122102370  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
122105129  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
122113201  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
122117204  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
122104856  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
122112321  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122103464  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
122118824  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
122097612  Map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122124378  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
122098790  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
122120089  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
122115167  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
122126135  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122107728  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122116096  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122096183  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122099029  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122117483  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
122119529  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122119668  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122103259  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122128383  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122104912  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122123634  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
122123765  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
122097049  Flna; filamin-A isoform X1 [KO:K04437]
122095902  Crkl; crk-like protein [KO:K04438]
122102190  Crk; adapter molecule crk isoform X1 [KO:K04438]
122114172  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
122108635  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
122097824  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122115378  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122116492  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122111502  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122111503  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122123649  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122098539  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122109435  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122095647  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
122118761  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
122105058  Rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
122120345  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122097750  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122126216  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122108943  Jun; transcription factor AP-1 [KO:K04448]
122100875  Jund; transcription factor jun-D [KO:K04449]
122120051  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
122100440  Tp53; cellular tumor antigen p53 [KO:K04451]
122124058  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
122117976  Max; protein max isoform X1 [KO:K04453]
122117295  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122113754  Hspb1; heat shock protein beta-1 [KO:K04455]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122110077  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
122124123  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
122117718  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
122109753  Ptpn7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
122099537  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122127457  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122095746  Dusp7; LOW QUALITY PROTEIN: dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122121315  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122115993  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122101203  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122101241  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122119139  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122097078  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
122109444  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122103497  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122125724  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122104505  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122111476  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
122111513  heat shock 70 kDa protein 1-like [KO:K03283]
122110292  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
122107242  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122114577  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122103406  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122098417  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122107928  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122107929  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122108067  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122108068  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122108069  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122108071  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122108072  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122102946  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122103419  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122117356  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122115754  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122125899  Relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dsp04070  Phosphatidylinositol signaling system
dsp04110  Cell cycle
dsp04115  p53 signaling pathway
dsp04210  Apoptosis
dsp04310  Wnt signaling pathway
dsp04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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