KEGG   PATHWAY: ecb04020
Entry
ecb04020                    Pathway                                
Name
Calcium signaling pathway - Equus caballus (horse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04020  Calcium signaling pathway
ecb04020

Other DBs
GO: 0019722
Organism
Equus caballus (horse) [GN:ecb]
Gene
100034157  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
100053312  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
100146819  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
100049920  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100051636  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100034081  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
100057711  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
100064117  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100056633  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100057856  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100034039  ADORA2A; adenosine receptor A2a [KO:K04266]
100063319  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
100146832  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100060659  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100147322  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100058846  DRD1; D(1A) dopamine receptor [KO:K04144]
100069604  DRD5; D(1B) dopamine receptor [KO:K05840]
102149608  HRH2; histamine H2 receptor [KO:K04150]
100034053  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100063709  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100050087  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
100060942  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
100058656  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100009688  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
100056464  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100050675  neuroendocrine secretory protein 55 [KO:K04632]
100050622  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100630668  PLN; cardiac phospholamban [KO:K05852]
106783340  SLN; sarcolipin [KO:K22642]
102149993  MRLN; myoregulin [KO:K22643]
100072406  C2H4orf3; LOW QUALITY PROTEIN: uncharacterized protein C4orf3 homolog [KO:K26467]
102149561  SMIM6; small integral membrane protein 6 [KO:K26468]
100064403  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100072684  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4 [KO:K05853] [EC:7.2.2.10]
791242  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100049576  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100053079  STIM1; stromal interaction molecule 1 isoform X4 [KO:K16059]
100066682  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
100059726  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100060645  ORAI2; protein orai-2 isoform X1 [KO:K16057]
100063559  ORAI3; protein orai-3 [KO:K16058]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100063873  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100058760  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100054582  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100070000  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100067492  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100070365  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100060521  neuronal acetylcholine receptor subunit alpha-7 isoform X2 [KO:K04809]
100059861  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100051329  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100063746  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100052410  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102148904  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100062954  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
111774159  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100060689  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
100061704  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
100062797  P2RX3; P2X purinoceptor 3 [KO:K05217]
100059626  P2RX4; P2X purinoceptor 4 [KO:K05218]
100051842  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
100058464  P2RX7; P2X purinoceptor 7 [KO:K05220]
100034090  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
100057437  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
100071830  RYR3; ryanodine receptor 3 [KO:K04963]
100072982  TRDN; triadin [KO:K23449]
100058343  CASQ1; calsequestrin-1 [KO:K23468]
100059622  CASQ2; calsequestrin-2 isoform X5 [KO:K23445]
100065909  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X3 [KO:K00476] [EC:1.14.11.16]
100072636  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100056882  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
100064906  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100054461  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
100071055  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100066003  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100059005  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100062644  EDNRA; endothelin-1 receptor precursor [KO:K04197]
100033875  EDNRB; endothelin receptor type B precursor [KO:K04198]
100073278  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100060603  GRM1; metabotropic glutamate receptor 1 isoform X3 [KO:K04603]
100060364  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100056400  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100034110  HRH1; histamine H1 receptor [KO:K04149]
100009685  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100057052  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100057852  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100034043  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100051274  NTSR1; neurotensin receptor type 1 [KO:K04211]
106781784  OXTR; oxytocin receptor [KO:K04229]
100056176  AVPR1A; vasopressin V1a receptor [KO:K04226]
100055260  AVPR1B; vasopressin V1b receptor [KO:K04227]
106780838  PTAFR; platelet-activating factor receptor [KO:K04279]
111774267  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
100053557  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
100009714  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100054699  BDKRB1; B1 bradykinin receptor [KO:K03915]
100054796  BDKRB2; B2 bradykinin receptor [KO:K03916]
100053491  TACR1; substance-P receptor [KO:K04222]
100034168  TACR2; substance-K receptor [KO:K04223]
100073088  TACR3; neuromedin-K receptor [KO:K04224]
111774174  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
100050529  thyrotropin-releasing hormone receptor-like [KO:K04282]
100056618  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100055506  CCKAR; cholecystokinin receptor type A [KO:K04194]
100055073  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
100050974  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100063136  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100067327  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100063170  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
100068567  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100060423  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100060488  FGF19; fibroblast growth factor 19 [KO:K22603]
100054542  FGF21; fibroblast growth factor 21 [KO:K22429]
100058460  FGF23; fibroblast growth factor 23 [KO:K22428]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100055238  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100050877  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100060890  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100065669  NGF; beta-nerve growth factor [KO:K02582]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102147382  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100067053  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100059216  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100050182  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X6 [KO:K05085] [EC:2.7.10.1]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100033957  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
100066773  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100064594  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100061700  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
100069852  NTRK3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100062492  MST1R; macrophage-stimulating protein receptor isoform X4 [KO:K05100] [EC:2.7.10.1]
100146791  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
111772100  uncharacterized protein LOC111772100 [KO:K10784]
106783094  uncharacterized protein LOC106783094 [KO:K10785]
100146643  immunoglobulin epsilon heavy chain [KO:K06856]
100054233  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
100064142  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
100058665  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100055670  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100061676  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100067798  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
111767502  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like isoform X1 [KO:K05861] [EC:3.1.4.11]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100068959  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100051154  TPCN1; two pore calcium channel protein 1 isoform X2 [KO:K16896]
102150167  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
100066441  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
100052719  MCOLN2; mucolipin-2 isoform X4 [KO:K04993]
100064441  MCOLN3; mucolipin-3 [KO:K04994]
100054066  SPHK2; sphingosine kinase 2 isoform X3 [KO:K04718] [EC:2.7.1.91]
100058875  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
100072824  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100064276  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100050762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100059103  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100071908  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100146128  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100073016  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100051811  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100056292  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100062752  CALM1; calmodulin-1 [KO:K02183]
100070422  calmodulin-like protein 3 [KO:K02183]
100071150  CALM3; calmodulin-3 [KO:K02183]
100629145  CALM2; calmodulin-2 [KO:K02183]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100065274  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
100061404  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100050040  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
100051524  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100051530  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100056559  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100070482  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100053698  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100050092  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100056611  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100056740  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X2 [KO:K08794] [EC:2.7.11.17]
100052300  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
100064138  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13 [KO:K04515] [EC:2.7.11.17]
100071654  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100072618  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6 [KO:K04515] [EC:2.7.11.17]
100146368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100073192  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100066433  TFEB; transcription factor EB [KO:K15590]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100054213  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100051079  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
791246  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100063339  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100054082  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
100064711  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
100070015  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
100054547  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100058602  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100147269  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100064775  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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  Authors
Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
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Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
PMID:10508738
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
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Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
PMID:19434403
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ecb04010  MAPK signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04210  Apoptosis
ecb04720  Long-term potentiation
ecb04730  Long-term depression
KO pathway
ko04020   
LinkDB

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