KEGG   PATHWAY: ecb05205
Entry
ecb05205                    Pathway                                
Name
Proteoglycans in cancer - Equus caballus (horse)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
ecb05205  Proteoglycans in cancer
ecb05205

Organism
Equus caballus (horse) [GN:ecb]
Gene
100034221  CD44; CD44 antigen precursor [KO:K06256]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100147634  CTTN; src substrate cortactin isoform X4 [KO:K06106]
100060842  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100055781  RRAS; ras-related protein R-Ras [KO:K07829]
100071586  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100064781  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100061212  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100068724  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
791249  ESR1; estrogen receptor [KO:K08550]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100058256  FLNA; filamin-A isoform X1 [KO:K04437]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100052764  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
102150569  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100064198  ANK2; ankyrin-2 isoform X1 [KO:K09255]
100062775  ANK3; ankyrin-3 isoform X1 [KO:K09259]
100062924  GAB1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100070959  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100060501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100063928  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X15 [KO:K12329]
100071503  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100061676  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100064138  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13 [KO:K04515] [EC:2.7.11.17]
100071654  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100072618  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6 [KO:K04515] [EC:2.7.11.17]
100146368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100061006  NANOG; homeobox protein NANOG [KO:K10164]
100064168  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100054238  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100314844  MIR21; eca-miR-21 [KO:K16863]
100272214  TWIST1; twist-related protein 1 [KO:K09069]
111773876  TWIST2; twist-related protein 2 [KO:K09069]
100315057  MIR10A; eca-miR-10a [KO:K16864]
100314983  MIR10B; eca-miR-10b [KO:K17393]
100066123  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100034120  DCN; decorin precursor [KO:K04660]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100053005  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100057481  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100061920  EIF4B; eukaryotic translation initiation factor 4B isoform X3 [KO:K03258]
100052368  RPS6; 40S ribosomal protein S6 [KO:K02991]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100055975  CAV1; caveolin-1 [KO:K06278]
100071136  CAV2; caveolin-2 [KO:K12958]
100058881  CAV3; caveolin-3 [KO:K12959]
100051450  CD63; CD63 antigen [KO:K06497]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100033900  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
100009701  TLR2; toll-like receptor 2 precursor [KO:K10159]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
111771935  toll-like receptor 4 [KO:K10160]
100059302  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
100033834  TNF; tumor necrosis factor [KO:K03156]
100034222  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
100059216  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100050182  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X6 [KO:K05085] [EC:2.7.10.1]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100055241  CTNNB1; catenin beta-1 [KO:K02105]
100061166  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100069711  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100071403  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
100033947  TIMP3; metalloproteinase inhibitor 3 precursor [KO:K16866]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100033948  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100056599  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100009681  LUM; lumican precursor [KO:K08122]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100071639  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100052084  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100033843  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100061267  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
100070602  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100071892  SDC1; syndecan-1 isoform X1 [KO:K06257]
100072886  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100033904  PLAUR; urokinase plasminogen activator surface receptor precursor [KO:K03985]
100033877  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100051715  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100063367  ITGA2; integrin alpha-2 [KO:K06481]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100059034  VTN; vitronectin [KO:K06251]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100034189  FN1; fibronectin isoform X1 [KO:K05717]
100070376  ITGB5; integrin beta-5 [KO:K06588]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100058859  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102147960  FZD7; frizzled-7 [KO:K02432]
106783041  FZD1; frizzled-1 [KO:K02432]
100050809  FZD2; frizzled-2 [KO:K02235]
100054732  FZD3; frizzled-3 [KO:K02329]
100050465  FZD4; frizzled-4 [KO:K02354]
100146215  FZD5; frizzled-5 [KO:K02375]
111771171  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100056351  FZD6; frizzled-6 [KO:K02376]
100062909  FZD10; frizzled-10 [KO:K02842]
100061635  FZD9; frizzled-9 [KO:K02842]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100059727  SDC2; syndecan-2 isoform X2 [KO:K16336]
100059467  EZR; ezrin [KO:K08007]
100061858  RDX; radixin isoform X3 [KO:K05762]
100065348  MSN; moesin [KO:K05763]
100070934  SDC4; syndecan-4 [KO:K16338]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100052205  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100056857  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100146191  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100055670  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102150529  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
100053811  PXN; paxillin isoform X1 [KO:K05760]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100629956  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
100067268  GPC1; glypican-1 [KO:K08107]
100034182  IGF2; insulin-like growth factor II precursor [KO:K13769]
100054222  GPC3; glypican-3 isoform X2 [KO:K08109]
100063931  WNT2B; protein Wnt-2b [KO:K00182]
100056092  WNT2; protein Wnt-2 precursor [KO:K00182]
100049880  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100061145  WNT3A; protein Wnt-3a [KO:K00312]
100071678  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100056017  WNT5B; protein Wnt-5b [KO:K00444]
100059157  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100058824  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
100053027  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100055450  WNT7A; protein Wnt-7a [KO:K00572]
111768287  protein Wnt-7a [KO:K00572]
100070360  WNT8B; protein Wnt-8b [KO:K00714]
100072609  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
100061110  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
100063730  WNT9B; protein Wnt-9b [KO:K01064]
100051649  WNT10B; protein Wnt-10b [KO:K01357]
111773843  WNT10A; protein Wnt-10a [KO:K01357]
100064184  WNT11; protein Wnt-11 [KO:K01384]
100071393  WNT16; protein Wnt-16 [KO:K01558]
100147450  SHH; sonic hedgehog protein [KO:K11988]
100033984  IHH; indian hedgehog protein [KO:K11989]
100033936  PTCH1; protein patched homolog 1 [KO:K06225]
100033990  SMO; smoothened homolog isoform X1 [KO:K06226]
100071701  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100061234  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
100061532  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100061956  HSPB2; heat shock protein beta-2 [KO:K09543]
100052882  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
ecb04010  MAPK signaling pathway
ecb04020  Calcium signaling pathway
ecb04066  HIF-1 signaling pathway
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04310  Wnt signaling pathway
ecb04340  Hedgehog signaling pathway
ecb04350  TGF-beta signaling pathway
ecb04370  VEGF signaling pathway
ecb04510  Focal adhesion
ecb04520  Adherens junction
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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