KEGG   PATHWAY: lcm04010
Entry
lcm04010                    Pathway                                
Name
MAPK signaling pathway - Latimeria chalumnae (coelacanth)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lcm04010  MAPK signaling pathway
lcm04010

Other DBs
GO: 0000165
Organism
Latimeria chalumnae (coelacanth) [GN:lcm]
Gene
102354855  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
102345610  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102357941  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102360815  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102362201  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
102353236  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102364726  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
102349456  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
102352709  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
102356715  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102355436  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
102364100  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
102354765  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
102358199  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
102347441  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
102354424  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
102358572  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
102367248  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
102350695  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
102360366  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
102349646  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
102350438  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
102350176  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
102351986  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
102350144  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
102349869  CACNG8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
102359855  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102362951  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102361415  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102364971  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102352260  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102367557  GNA12; G protein subunit alpha 12 [KO:K04346]
102348748  GNG12; G protein subunit gamma 12 [KO:K04347]
102352270  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
102361410  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102346544  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
102363964  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
102353071  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
102367157  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102363413  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102361460  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102345538  RASGRP4; RAS guanyl releasing protein 4 [KO:K04350]
102347423  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102348970  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102353784  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102349377  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102351274  NF1; neurofibromin 1 [KO:K08052]
102354006  RASA1; RAS p21 protein activator 1 [KO:K04352]
102346776  RASA2; RAS p21 protein activator 2 [KO:K08053]
102354992  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102354357  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102348800  pro-epidermal growth factor-like [KO:K04357]
102356822  EGF; epidermal growth factor [KO:K04357]
102367184  TGFA; transforming growth factor alpha [KO:K08774]
102355423  EREG; epiregulin [KO:K09784]
106706150  amphiregulin-like [KO:K09782]
102355882  AREG; amphiregulin [KO:K09782]
102355138  FGF1; fibroblast growth factor 1 [KO:K18496]
102351407  FGF2; fibroblast growth factor 2 [KO:K18497]
102352812  FGF6; fibroblast growth factor 6 [KO:K04358]
102359750  FGF22; fibroblast growth factor 22 [KO:K04358]
102345389  FGF17; fibroblast growth factor 17 [KO:K04358]
102357981  FGF5; fibroblast growth factor 5 [KO:K04358]
102352226  FGF20; fibroblast growth factor 20 [KO:K04358]
102346137  FGF8; fibroblast growth factor 8 [KO:K04358]
102346042  FGF16; fibroblast growth factor 16 [KO:K04358]
102349922  FGF18; fibroblast growth factor 18 [KO:K04358]
102351067  FGF7; fibroblast growth factor 7 [KO:K04358]
102364799  FGF3; fibroblast growth factor 3 [KO:K04358]
102360221  FGF4; fibroblast growth factor 4 [KO:K04358]
102353488  FGF10; fibroblast growth factor 10 [KO:K04358]
102362535  FGF9; fibroblast growth factor 9 [KO:K04358]
102356182  fibroblast growth factor 18-like [KO:K04358]
102360486  FGF19; fibroblast growth factor 19 [KO:K22603]
102351727  FGF23; fibroblast growth factor 23 [KO:K22428]
102364322  NGF; nerve growth factor [KO:K02582]
102353793  BDNF; brain derived neurotrophic factor [KO:K04355]
102356607  NTF3; neurotrophin 3 [KO:K04356]
102367207  neurotrophin-4-like [KO:K12457]
102348278  INS; insulin [KO:K04526]
102365620  insulin-like growth factor I [KO:K05459]
102361051  IGF1; insulin like growth factor 1 [KO:K05459]
102347414  insulin-like growth factor III [KO:K13769]
102348010  IGF2; insulin like growth factor 2 [KO:K13769]
102352946  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102355435  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102356509  PDGFC; platelet derived growth factor C [KO:K05450]
102351685  PDGFD; platelet derived growth factor D [KO:K05450]
102364515  kit ligand-like [KO:K05461]
102347582  VEGFB; vascular endothelial growth factor B [KO:K05448]
102367264  VEGFA; vascular endothelial growth factor A [KO:K05448]
102359260  PGF; placental growth factor [KO:K16859]
102361405  placenta growth factor-like [KO:K16859]
102360711  vascular endothelial growth factor C-like [KO:K05449]
102361433  VEGFD; vascular endothelial growth factor D [KO:K05449]
102367077  VEGFC; vascular endothelial growth factor C [KO:K05449]
102354206  HGF; hepatocyte growth factor [KO:K05460]
102354081  ANGPT1; angiopoietin 1 [KO:K05465]
102364139  ANGPT4; angiopoietin 4 [KO:K05465]
102354822  angiopoietin-2-like [KO:K05466]
102357902  ANGPT2; angiopoietin 2 [KO:K05466]
102361018  EFNA3; ephrin A3 [KO:K05462]
102361274  EFNA4; ephrin A4 [KO:K05462]
102361706  EFNA2; ephrin A2 [KO:K05462]
102345217  EFNA5; ephrin A5 [KO:K05462]
102361905  EFNA1; ephrin A1 [KO:K05462]
102363070  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102358650  NRTN; neurturin [KO:K25414]
102352211  ARTN; artemin [KO:K25415]
102354055  PSPN; persephin [KO:K25416]
102348821  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102353616  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102360220  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102361014  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102349925  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102364583  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102345296  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102357325  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
102367421  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
102349025  NGFR; nerve growth factor receptor [KO:K02583]
102354132  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102363882  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102367342  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102353753  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102361386  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102349790  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102363945  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102346199  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102345121  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102365485  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102359993  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102362684  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102366006  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102358253  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102355118  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102358285  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102353904  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102347108  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102348404  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102355427  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102352473  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102357700  GTPase HRas-like [KO:K07827]
102361045  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102358831  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102349532  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07830]
102359118  MRAS; muscle RAS oncogene homolog [KO:K07831]
102356108  ras-related protein M-Ras-like [KO:K07831]
102351967  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
102365161  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102357545  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102358560  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102350370  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102354656  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102355992  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102354262  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102345480  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
102352116  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
102362733  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102365858  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102365238  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102359472  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
102365086  ATF4; activating transcription factor 4 [KO:K04374]
102363355  ETS domain-containing protein Elk-1-like [KO:K04375]
102351917  ELK1; ELK1, ETS transcription factor [KO:K04375]
102365795  ELK4; ELK4, ETS transcription factor [KO:K04376]
102359985  transcriptional regulator Myc-2-like [KO:K04377]
102357079  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102364116  SRF; serum response factor [KO:K04378]
102361375  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102357089  microtubule-associated protein tau-like [KO:K04380]
102356916  STMN1; stathmin 1 [KO:K04381]
102351206  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
102356324  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102352898  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102360293  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
102357196  TNF; tumor necrosis factor [KO:K03156]
102364535  interleukin-1 beta-like [KO:K04519]
102364242  TGFB1; transforming growth factor beta 1 [KO:K13375]
102352268  transforming growth factor beta-2-like [KO:K13376]
102358422  TGFB2; transforming growth factor beta 2 [KO:K13376]
102358543  TGFB3; transforming growth factor beta 3 [KO:K13377]
102356355  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102365673  interleukin-1 receptor type 1-like [KO:K04386]
102358615  interleukin-1 receptor type 1-like [KO:K04386]
102354139  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102350402  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102346621  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102356233  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
102366280  FASLG; Fas ligand [KO:K04389]
102361141  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
102349412  FAS; Fas cell surface death receptor [KO:K04390]
102367135  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102352006  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102351732  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102364586  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102358869  CDC42; cell division cycle 42 [KO:K04393]
102365247  TRADD; TNFRSF1A associated via death domain [KO:K03171]
106705928  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102360751  TNF receptor-associated factor 1-like [KO:K03173] [EC:2.3.2.27]
102355783  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102358173  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102349300  DAXX; death domain associated protein [KO:K02308]
102348650  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102359430  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102365908  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102353931  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102353479  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102361538  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102349018  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102359833  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102364705  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102366266  ECSIT; ECSIT signalling integrator [KO:K04405]
102348521  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102361276  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102349047  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102367003  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102354634  STK4; serine/threonine kinase 4 [KO:K04411]
102346204  serine/threonine-protein kinase 3-like [KO:K04412]
102354528  serine/threonine-protein kinase 3 [KO:K04412]
106707012  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102367513  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102355070  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102364487  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102350566  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102353974  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102350357  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
102356869  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102347264  mitogen-activated protein kinase kinase kinase MLK4-like [KO:K17534] [EC:2.7.11.25]
102362205  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102367402  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102364913  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102352283  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04426] [EC:2.7.11.25]
102358159  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102366133  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102349547  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
102352645  serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
102361969  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
102352547  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102365163  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102351267  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102362389  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102366999  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
102352348  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
102346900  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
102345455  FLNA; filamin A [KO:K04437]
102345797  crk-like protein [KO:K04438]
102350481  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102352845  crk-like protein [KO:K04438]
102364341  crk-like protein [KO:K04438]
102360512  ARRB1; arrestin beta 1 [KO:K04439]
102348719  ARRB2; arrestin beta 2 [KO:K04439]
102357573  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102351693  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102351958  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102354316  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102354774  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102358042  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102358958  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102362783  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102347953  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102352936  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102345787  RPS6KA4; ribosomal protein S6 kinase A4 [KO:K04445] [EC:2.7.11.1]
102366036  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102350112  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102349968  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
102356282  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102350279  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102358101  transcription factor AP-1-like [KO:K04448]
102357240  JUND; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
106703183  cyclic AMP-responsive element-binding protein 5-like [KO:K04450]
102366239  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102366539  TP53; tumor protein p53 [KO:K04451]
102361121  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102349973  MAX; MYC associated factor X [KO:K04453]
102361694  MEF2C; myocyte enhancer factor 2C [KO:K04454]
102362208  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
102359797  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102359272  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102346546  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102351446  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
102355597  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
102350959  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
102361330  receptor-type tyrosine-protein phosphatase R-like [KO:K04458] [EC:3.1.3.48]
102348627  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102364361  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102364866  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102364337  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102358462  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102345316  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102367101  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102366865  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102352074  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102352064  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102357439  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102367007  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102352599  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102361609  PPP5D1; PPP5 tetratricopeptide repeat domain containing 1 [KO:K04460] [EC:3.1.3.16]
102351165  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
102364156  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102353228  heat shock cognate 71 kDa protein-like [KO:K03283]
102351854  heat shock 70 kDa protein 1-like [KO:K03283]
102359148  heat shock 70 kDa protein [KO:K03283]
102357450  Hsp70; heat shock cognate 71 kDa protein-like [KO:K03283]
102367553  heat shock cognate 71 kDa protein [KO:K03283]
102358043  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
102357895  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102358623  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102364494  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102351315  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102361819  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102358966  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102351908  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102352356  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102353948  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
102356725  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102349797  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102360145  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
lcm04070  Phosphatidylinositol signaling system
lcm04110  Cell cycle
lcm04115  p53 signaling pathway
lcm04210  Apoptosis
lcm04310  Wnt signaling pathway
KO pathway
ko04010   
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