KEGG   PATHWAY: mpah04010
Entry
mpah04010                   Pathway                                
Name
MAPK signaling pathway - Mus pahari (shrew mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04010  MAPK signaling pathway
mpah04010

Other DBs
GO: 0000165
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110337404  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110318209  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110317086  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110325961  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110321218  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
110313596  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110332124  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110338208  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
110334522  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110322010  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110316372  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
110327210  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
110325173  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
110316341  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
110332782  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
110318390  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
110334476  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
110317586  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
110332646  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
110334833  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
110328680  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
110331734  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
110332156  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
110337070  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
110336489  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
110336849  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110332714  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110320075  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110336366  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
110312844  Gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
110314464  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110337711  Gng14; uncharacterized LOC105372280 homolog [KO:K04347]
110321008  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110325335  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110325367  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110330477  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
110322987  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110327751  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
110329065  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
110317644  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
110318723  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
110335530  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
110329512  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
110331829  Nf1; neurofibromin [KO:K08052]
110328850  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
110327267  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
110319932  Rap1a; ras-related protein Rap-1A [KO:K04353]
110326460  Rap1b; ras-related protein Rap-1b isoform X1 [KO:K07836]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110316577  Tgfa; protransforming growth factor alpha [KO:K08774]
110331017  Ereg; proepiregulin [KO:K09784]
110330966  Areg; amphiregulin [KO:K09782]
110333309  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110320512  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
110314005  Fgf16; fibroblast growth factor 16 [KO:K04358]
110325648  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110318603  Fgf7; fibroblast growth factor 7 [KO:K04358]
110326486  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110325518  Fgf9; fibroblast growth factor 9 [KO:K04358]
110337766  Fgf3; fibroblast growth factor 3 [KO:K04358]
110332000  Fgf18; fibroblast growth factor 18 [KO:K04358]
110336807  Fgf20; fibroblast growth factor 20 [KO:K04358]
110317154  Fgf6; fibroblast growth factor 6 [KO:K04358]
110327081  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110330786  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110336606  Fgf4; fibroblast growth factor 4 [KO:K04358]
110329060  Fgf10; fibroblast growth factor 10 [KO:K04358]
110334904  Fgf19; fibroblast growth factor 19 [KO:K22603]
110338839  Fgf21; fibroblast growth factor 21 [KO:K22429]
110317286  Fgf23; fibroblast growth factor 23 [KO:K22428]
110320585  Ngf; beta-nerve growth factor [KO:K02582]
110318089  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110316535  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
110335320  Ntf4; neurotrophin-4 [KO:K12457]
110333420  insulin-1 [KO:K04526]
110326410  insulin-2 [KO:K04526]
110326668  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110316402  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110312881  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110334927  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
110327924  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110319957  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110320052  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
110326225  Kitlg; kit ligand isoform X1 [KO:K05461]
110320589  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110335444  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110327962  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110324731  Pgf; placenta growth factor isoform X1 [KO:K16859]
110313900  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
110336732  Vegfc; vascular endothelial growth factor C [KO:K05449]
110316234  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110334489  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
110336428  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
110319289  Angpt4; angiopoietin-4 [KO:K05467]
110320485  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110326602  Efna2; ephrin-A2 [KO:K05462]
110320552  Efna4; ephrin-A4 [KO:K05462]
110320381  Efna3; ephrin-A3 [KO:K05462]
110335603  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110329057  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110335936  Nrtn; neurturin [KO:K25414]
110323564  Artn; artemin isoform X1 [KO:K25415]
110335852  Pspn; persephin [KO:K25416]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110331339  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110326297  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110321248  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110336809  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
110326449  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110330788  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110333996  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110331904  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110319787  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110333600  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110336317  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110324292  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110331028  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110333065  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110333327  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110330230  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110312926  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110339167  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
110331550  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110330463  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110316104  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110322884  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
110323696  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110315801  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110318967  GTPase HRas-like isoform X1 [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110338480  GTPase HRas-like [KO:K02833]
110333346  GTPase HRas-like [KO:K02833]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110320340  Nras; GTPase NRas [KO:K07828]
110329400  Rras; ras-related protein R-Ras [KO:K07829]
110321732  Rras2; ras-related protein R-Ras2 [KO:K07830]
110327401  Mras; ras-related protein M-Ras [KO:K07831]
110314283  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
110316269  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110320398  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110326572  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
110323010  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
110337879  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
110313419  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
110313426  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
110323590  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
110334651  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110314286  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110321782  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110334656  Myc; myc proto-oncogene protein [KO:K04377]
110335542  Srf; serum response factor [KO:K04378]
110324365  Fos; proto-oncogene c-Fos isoform X1 [KO:K04379]
110331493  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
110322944  Stmn1; stathmin [KO:K04381]
110317835  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
110319432  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
110318953  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110336949  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110318542  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110321382  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
110335791  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
110319393  Il1a; interleukin-1 alpha [KO:K04383]
110319321  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
110336543  Tgfb1; transforming growth factor beta-1 isoform X1 [KO:K13375]
110321649  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
110324521  Tgfb3; transforming growth factor beta-3 [KO:K13377]
110316225  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110321407  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
110329561  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
110322784  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110327573  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110322215  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110332797  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110333539  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110334678  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
110331528  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110322847  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110337608  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
110336608  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110318405  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110335556  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
110327862  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110313647  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110334455  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
110318382  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110316550  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
110326839  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110333844  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110334874  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
110338176  Tab2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
110327397  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
110335544  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
110321281  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
110325178  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
110319929  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110329559  Pak2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
110318679  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
110334720  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
110320280  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
110333248  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
110328949  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
110327022  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
110333106  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
110331495  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
110324226  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
110327052  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
110337368  Map3k21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
110335072  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
110329718  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
110318175  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
110323270  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
110337870  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110338656  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110338018  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
110313230  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
110328921  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
110332119  Taok1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
110331563  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110336400  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110331197  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110331335  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
110317739  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
110334921  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
110337999  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
110314123  Flna; filamin-A isoform X1 [KO:K04437]
110331717  Crk; adapter molecule crk isoform X1 [KO:K04438]
110329586  Crkl; crk-like protein isoform X1 [KO:K04438]
110332625  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
110315912  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110334495  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110337896  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110337946  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110334829  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110339137  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
110321250  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110327440  Mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
110324254  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
110339061  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
110318116  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
110333017  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110337199  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110323252  Jun; transcription factor AP-1 [KO:K04448]
110336462  Jund; transcription factor jun-D [KO:K04449]
110317821  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110331731  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110326609  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
110324327  Max; protein max isoform X1 [KO:K04453]
110329159  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
110312972  Hspb1; heat shock protein beta-1 [KO:K04455]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110324509  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
110326200  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
110317657  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
110321547  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
110337954  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
110316379  Dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110318984  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110336426  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110334483  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110323126  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110327524  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110326343  Dusp6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110313969  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
110322151  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
110332404  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
110336333  Ppp5c; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
110335440  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
110335695  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
110335998  heat shock 70 kDa protein 1A [KO:K03283]
110327293  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
110319807  Mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
110327468  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
110331679  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
110334786  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110332218  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110334538  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110336182  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110313464  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110331754  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
110319789  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110317480  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110317041  Rela; transcription factor p65 [KO:K04735]
110336681  Relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
mpah04070  Phosphatidylinositol signaling system
mpah04110  Cell cycle
mpah04115  p53 signaling pathway
mpah04210  Apoptosis
mpah04310  Wnt signaling pathway
mpah04668  TNF signaling pathway
KO pathway
ko04010   
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