KEGG   PATHWAY: mthb04010
Entry
mthb04010                   Pathway                                
Name
MAPK signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04010  MAPK signaling pathway
mthb04010

Other DBs
GO: 0000165
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126942455  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126936874  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
126930225  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
126948779  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
126940288  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
126945535  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
126939595  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
126944816  voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
126963681  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
126939641  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
126949899  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
126948632  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
126948780  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
126930228  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
126938447  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
126962937  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
126930167  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
126933022  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
126938366  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
126963748  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
126944396  voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
126938360  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
126938362  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
126943339  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
126943336  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
126941688  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
126942437  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
126937647  cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
126963591  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126951492  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
126942836  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126939573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126954988  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
126962430  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126961264  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126937786  calcineurin subunit B type 2 [KO:K06268]
126934067  calcineurin subunit B type 1 isoform X1 [KO:K06268]
126960038  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
126957570  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
126960104  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
126935564  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126934266  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
126942141  RAS guanyl-releasing protein 4 [KO:K12363]
126954894  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126938974  neurofibromin isoform X1 [KO:K08052]
126957382  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
126947414  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
126930173  ras-related protein Rap-1A [KO:K04353]
126930986  ras-related protein Rap-1b [KO:K07836]
126937705  ras-related protein Rap-1b-like [KO:K07836]
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126934085  protransforming growth factor alpha isoform X1 [KO:K08774]
126954920  proepiregulin [KO:K09784]
126954907  amphiregulin [KO:K09782]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126954986  fibroblast growth factor 2 [KO:K18497]
126942993  fibroblast growth factor 22 [KO:K04358]
126962737  fibroblast growth factor 8 isoform X1 [KO:K04358]
126931752  fibroblast growth factor 6 [KO:K04358]
126956981  fibroblast growth factor 18 [KO:K04358]
126957199  fibroblast growth factor 10 [KO:K04358]
126946335  fibroblast growth factor 16 [KO:K04358]
126958707  fibroblast growth factor 7 [KO:K04358]
126940532  fibroblast growth factor 9 [KO:K04358]
126935967  fibroblast growth factor 3 [KO:K04358]
126935973  fibroblast growth factor 4 [KO:K04358]
126960920  fibroblast growth factor 20 [KO:K04358]
126961295  fibroblast growth factor 17 isoform X1 [KO:K04358]
126935968  fibroblast growth factor 19 [KO:K22603]
126943598  fibroblast growth factor 21 [KO:K22429]
126931744  fibroblast growth factor 23 [KO:K22428]
126930848  beta-nerve growth factor [KO:K02582]
126934686  brain-derived neurotrophic factor isoform X1 [KO:K04355]
126930453  neurotrophin-3 isoform X1 [KO:K04356]
126943596  neurotrophin-4 [KO:K12457]
126935873  insulin isoform X1 [KO:K04526]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126935883  insulin-like growth factor II [KO:K13769]
126950578  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126963759  platelet-derived growth factor subunit B [KO:K17386]
126936264  platelet-derived growth factor D isoform X1 [KO:K05450]
126954312  platelet-derived growth factor C [KO:K05450]
126929640  macrophage colony-stimulating factor 1 [KO:K05453]
126929998  kit ligand isoform X1 [KO:K05461]
126943138  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126935608  vascular endothelial growth factor B isoform X1 [KO:K16858]
126959573  placenta growth factor isoform X1 [KO:K16859]
126955710  vascular endothelial growth factor C isoform X1 [KO:K05449]
126946911  vascular endothelial growth factor D isoform X1 [KO:K05449]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126961624  angiopoietin-1 isoform X1 [KO:K05465]
126961064  angiopoietin-2 isoform X1 [KO:K05466]
126964222  angiopoietin-4 isoform X1 [KO:K05467]
126942796  ephrin-A2 [KO:K05462]
126957121  ephrin-A5 isoform X1 [KO:K05462]
126934418  ephrin-A4 isoform X1 [KO:K05462]
126934582  ephrin-A3 isoform X1 [KO:K05462]
126934657  ephrin-A1 [KO:K05462]
126956073  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
126942809  neurturin [KO:K25414]
126960840  artemin isoform X1 [KO:K25415]
126942793  persephin [KO:K25416]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126938415  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
126931198  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
126932508  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
126961189  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126962662  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126955560  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126956321  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126939872  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126948042  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
126937627  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126954734  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126956584  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126954735  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126940719  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
126940714  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126956306  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
126954733  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126937984  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
126956768  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126962192  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126943140  ras-related protein R-Ras [KO:K07829]
126936606  ras-related protein R-Ras2 [KO:K07830]
126948197  ras-related protein M-Ras isoform X1 [KO:K07831]
126945567  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126955217  ragulator complex protein LAMTOR3 [KO:K04370]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126942612  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
126961446  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
126957229  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
126945242  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
126946218  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
126953765  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
126963745  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126944416  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126945587  ETS domain-containing protein Elk-1 [KO:K04375]
126934689  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1-like [KO:K04375]
126939053  ETS domain-containing protein Elk-4 [KO:K04376]
126960612  myc proto-oncogene protein [KO:K04377]
126952400  serum response factor isoform X1 [KO:K04378]
126959543  protein c-Fos [KO:K04379]
126938919  microtubule-associated protein tau isoform X1 [KO:K04380]
126953300  LOW QUALITY PROTEIN: microtubule-associated protein tau-like [KO:K04380]
126955982  stathmin isoform X1 [KO:K04381]
126943448  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
126950100  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126959281  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126959808  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
126959810  cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
126959812  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126933365  interleukin-1 alpha isoform X1 [KO:K04383]
126933366  interleukin-1 beta [KO:K04519]
126941768  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126948495  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126959539  transforming growth factor beta-3 proprotein [KO:K13377]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126934234  interleukin-1 receptor type 1 [KO:K04386]
126948023  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
126938052  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126946646  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126957322  monocyte differentiation antigen CD14 [KO:K04391]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126963767  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126939124  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126945020  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126936973  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126952729  death domain-associated protein 6 isoform X1 [KO:K02308]
126948486  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
126945458  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
126931312  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
126936615  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126942832  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
126937334  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
126939469  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
126963720  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
126952491  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
126942654  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
126933540  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
126934270  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
126941973  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
126935687  serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
126947966  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126963827  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
126961142  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
126935558  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
126963358  mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
126957142  mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
126935336  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
126933061  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
126939545  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
126958762  mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
126941969  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
126942330  mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
126931102  mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
126948442  mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
126932482  mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
126958463  mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
126952847  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
126952936  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126952364  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
126930607  serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
126944424  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
126938760  serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
126939572  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126942652  dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
126939044  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
126939854  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
126935744  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
126929428  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
126944581  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
126945450  filamin-A isoform X1 [KO:K04437]
126938875  adapter molecule crk isoform X1 [KO:K04438]
126929691  crk-like protein [KO:K04438]
126939720  beta-arrestin-2 [KO:K04439]
126935084  beta-arrestin-1 isoform X1 [KO:K04439]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126931474  MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
126949445  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
126948703  MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
126959645  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
126935565  ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
126929115  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
126941512  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
126944052  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126962798  transcription factor Jun [KO:K04448]
126942299  transcription factor JunD [KO:K04449]
126932678  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
126930406  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
126959765  protein max isoform X1 [KO:K04453]
126957487  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
126950413  heat shock protein beta-1 [KO:K04455]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126958978  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
126930003  receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
126934652  tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
126939031  tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
126956345  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
126961784  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126930740  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126962789  dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126934316  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126935830  dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126948690  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126930951  dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
126945419  dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
126937614  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
126938655  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
126943456  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
126934137  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
126943192  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
126934789  heat shock cognate 71 kDa protein [KO:K03283]
126953203  heat shock 70 kDa protein 1B [KO:K03283]
126953204  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A-like [KO:K03283]
126953205  heat shock 70 kDa protein 1-like [KO:K03283]
126948321  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
126958153  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
126939027  mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
126931034  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
126938709  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126938723  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126962742  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126943527  transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mthb04070  Phosphatidylinositol signaling system
mthb04110  Cell cycle
mthb04115  p53 signaling pathway
mthb04210  Apoptosis
mthb04310  Wnt signaling pathway
mthb04668  TNF signaling pathway
KO pathway
ko04010   
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