KEGG   PATHWAY: ppam05022
Entry
ppam05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ppam05022  Pathways of neurodegeneration - multiple diseases
ppam05022

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129075422  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
129071577  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
129085354  SNCA; alpha-synuclein [KO:K04528]
129075660  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
129078007  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
129073218  RNA-binding protein FUS-like [KO:K13098]
129074132  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
129078080  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
129087398  ATXN2; ataxin-2 isoform X1 [KO:K23625]
129077491  HTT; huntingtin [KO:K04533]
129075221  ATXN1L; ataxin-1-like [KO:K23616]
129085489  ATXN1; ataxin-1 [KO:K23616]
129065823  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
129074435  LOW QUALITY PROTEIN: ataxin-3-like [KO:K11863] [EC:3.4.22.-]
129070831  PRNP; major prion protein [KO:K05634]
129068425  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129079421  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
129064077  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
129068544  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
129067827  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129072823  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
129078244  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129088228  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
129068613  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129064066  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
129070855  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129070857  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129070698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129076731  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129081586  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
129062505  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
129078195  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
129087685  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129084965  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129067386  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
129083234  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
129079449  RYR2; ryanodine receptor 2 [KO:K04962]
129064384  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
129070508  PDYN; proenkephalin-B [KO:K15840]
129072307  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
129079149  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129083674  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129085005  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129086684  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
129082896  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129066528  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
129072576  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
129073349  GRIA3; glutamate receptor 3 [KO:K05199]
129086015  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
129079505  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129073529  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129088299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129065030  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129072943  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129083421  STX1A; syntaxin-1A [KO:K04560]
129061280  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
129078083  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129072376  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129087287  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129065916  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
129073012  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
129084304  DERL1; derlin-1 [KO:K11519]
129078190  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
129074851  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
129075535  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
129076160  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
129076768  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
129064336  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
129071299  ubiquitin-like [KO:K02927]
129084707  ubiquitin-like [KO:K02927]
129088062  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
129069454  LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129072049  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
129066831  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129067544  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129088211  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
129068786  UBB; polyubiquitin-B [KO:K04551]
129087151  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
129081886  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
129062962  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
129082584  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
129070398  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
129078868  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
129063668  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
129080541  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
129066001  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
129072336  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
129079275  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
129086975  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
129069303  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
129074040  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
129088087  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
129062376  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
129063103  PSMC2; 26S proteasome regulatory subunit 7 isoform X1 [KO:K03061]
129079112  26S proteasome regulatory subunit 7 [KO:K03061]
129075104  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
129065838  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
129076643  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
129066032  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
129081429  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
129070204  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
129077083  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
129069109  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
129087043  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
129087283  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
129070222  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
129070262  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
129088511  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
129075229  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
129073146  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
129062287  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
129074425  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
129061831  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
129075451  26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
129083233  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
129073845  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
129063442  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
129077648  UCHL1; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
129065235  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
129087803  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
129065346  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
129078846  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
129086333  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
129079903  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
129073953  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
129062605  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
129079274  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
129075092  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
129072373  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
129062786  GPR37; prosaposin receptor GPR37 [KO:K04243]
129086223  SEPTIN5; septin-5 isoform X1 [KO:K04557]
129083876  SNCAIP; synphilin-1 [KO:K04558]
129079269  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
129070599  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
129082078  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
129075812  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129087130  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
129070208  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129079528  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129078555  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129086067  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
129076640  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
129085559  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129065952  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
129077836  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129074725  SLC6A3; LOW QUALITY PROTEIN: sodium-dependent dopamine transporter [KO:K05036]
129069140  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
129068534  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129081681  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129074799  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129076111  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
129066622  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129081580  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
129073794  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129075808  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129062810  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129062895  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129062966  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129063510  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129077877  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129075999  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
129078572  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129079300  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129074234  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
129068255  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
129076737  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129061573  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129071413  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
129075001  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129065821  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
129063444  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129062202  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
129080430  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129071855  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129080483  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
129076733  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
129078219  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129073965  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
129061437  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129077119  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129084321  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129083592  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129063038  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
129065242  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129080402  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129082090  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129081425  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129071966  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129069068  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129074405  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129080072  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
129068340  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
129062244  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129072781  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129074559  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
129075622  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
129082086  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
129085977  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
129068180  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
129084412  cytochrome c1, heme protein, mitochondrial [KO:K00413]
129087602  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
129076751  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
129078685  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
129069416  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
129063220  cytochrome b-c1 complex subunit 7-like [KO:K00417]
129084220  cytochrome b-c1 complex subunit 7 [KO:K00417]
129066439  cytochrome b-c1 complex subunit 8 [KO:K00418]
129087380  cytochrome b-c1 complex subunit 9 [KO:K00419]
129081642  cytochrome b-c1 complex subunit 10 [KO:K00420]
129083132  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
129070485  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
129064218  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
129080578  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
129077999  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
129087477  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
129082512  cytochrome c oxidase subunit 6B2 [KO:K02267]
129069210  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129083194  cytochrome c oxidase subunit 6B1 [KO:K02267]
129070176  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129077881  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129071519  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129072246  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129074723  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
129084242  cytochrome c oxidase subunit 6C [KO:K02268]
129083211  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
129065908  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
129067112  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
129087868  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
129077717  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
129084869  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129065349  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
129086072  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129074346  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129088401  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
129074665  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
129068626  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
129069924  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
129078697  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
129075788  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
129087071  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
129080666  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
129073752  ATP synthase subunit delta, mitochondrial [KO:K02134]
129073755  ATP synthase subunit delta, mitochondrial [KO:K02134]
129063885  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
129061960  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
129088538  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129084810  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
129080120  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
129083505  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129086489  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
129074314  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
129075499  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
129078764  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129066687  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129082087  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
129082846  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
129069891  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
129063259  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129082875  CALM3; calmodulin-3 [KO:K02183]
129084580  calmodulin-like [KO:K02183]
129065634  CALM2; calmodulin-2 [KO:K02183]
129065835  CALM1; calmodulin-1 [KO:K02183]
129078752  CALML6; calmodulin-like protein 6 [KO:K02183]
129086576  calmodulin-alpha-like [KO:K02183]
129087301  CALML3; calmodulin-like protein 3 [KO:K02183]
129075010  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129069877  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129085325  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129079661  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129081330  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129068612  BAD; bcl2-associated agonist of cell death [KO:K02158]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129069755  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129068522  FADD; FAS-associated death domain protein [KO:K02373]
129080711  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129081160  BID; BH3-interacting domain death agonist [KO:K04726]
129082924  BAX; apoptosis regulator BAX [KO:K02159]
129066993  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
129084928  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
129086785  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
129083640  TRAP1; heat shock protein 75 kDa, mitochondrial isoform X1 [KO:K09488]
129069854  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129071050  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
129067084  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
129075491  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129075707  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129064788  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129062855  ADP/ATP translocase 3-like [KO:K05863]
129076152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129069951  ADP/ATP translocase 2-like [KO:K05863]
129083503  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129064550  ADP/ATP translocase 2-like [KO:K05863]
129064887  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129085704  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129079754  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129061237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129069841  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129082218  cytochrome c-like [KO:K08738]
129062822  cytochrome c [KO:K08738]
129083450  cytochrome c-like [KO:K08738]
129084433  cytochrome c-like [KO:K08738]
129071395  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
129075586  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129064891  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129083786  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
129073583  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
129075737  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
129064545  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
129072581  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
129073618  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
129067685  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
129081117  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
129075687  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
129070790  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
129076652  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
129075648  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
129065002  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
129083136  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
129070757  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
129084168  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
129073096  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
129075846  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
129061862  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
129074630  WDR41; WD repeat-containing protein 41 [KO:K23610]
129068762  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
129082349  C9orf72; guanine nucleotide exchange factor C9orf72 homolog [KO:K23609]
129074944  RAB8A; ras-related protein Rab-8A [KO:K07901]
129069554  RAB39B; ras-related protein Rab-39B [KO:K07925]
129081340  RAB1A; ras-related protein Rab-1A [KO:K07874]
129075656  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129087425  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
129068766  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
129084586  ATG101; autophagy-related protein 101 [KO:K19730]
129081446  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
129087922  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
129081447  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
129072892  BECN2; beclin-2 [KO:K08334]
129087026  BECN1; beclin-1 [KO:K08334]
129088426  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
129066012  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
129069959  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
129078690  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
129068593  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
129065791  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
129069262  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
129070236  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
129065918  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
129080424  ALS2; alsin isoform X1 [KO:K04575]
129088376  RAB5A; ras-related protein Rab-5A [KO:K07887]
129078413  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129076256  charged multivesicular body protein 2b-like [KO:K12192]
129079947  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
129067698  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
129064280  SPG11; spatacsin [KO:K19026]
129066972  TNF; tumor necrosis factor [KO:K03156]
129071418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129075646  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
129067363  DAXX; death domain-associated protein 6 [KO:K02308]
129068738  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129070245  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129087355  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
129068553  CCS; copper chaperone for superoxide dismutase [KO:K04569]
129065480  copper chaperone for superoxide dismutase-like [KO:K04569]
129069699  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
129071943  GPX8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
129065960  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
129066539  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
129087736  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
129080471  CAT; catalase [KO:K03781] [EC:1.11.1.6]
129084665  PRPH; peripherin [KO:K07607]
129074901  NEFL; neurofilament light polypeptide [KO:K04572]
129074898  NEFM; neurofilament medium polypeptide [KO:K04573]
129087465  NEFH; neurofilament heavy polypeptide [KO:K04574]
129061932  KIF5C; kinesin heavy chain [KO:K10396]
129075817  KIF5A; kinesin heavy chain [KO:K10396]
129077757  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
129068558  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
129082857  KLC3; kinesin light chain 3 [KO:K10407]
129066220  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
129067468  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
129084868  TUBA1C; tubulin alpha-1C chain [KO:K07374]
129084870  tubulin alpha-1A chain [KO:K07374]
129084873  tubulin alpha-1B chain [KO:K07374]
129084896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
129086316  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
129086325  tubulin alpha-3 chain [KO:K07374]
129073196  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
129080325  tubulin alpha-1D chain [KO:K07374]
129080327  LOW QUALITY PROTEIN: tubulin alpha-4A chain-like [KO:K07374]
129080851  tubulin alpha-1A chain-like [KO:K07374]
129080992  TUBA8; tubulin alpha-8 chain [KO:K07374]
129061558  TUBB4A; tubulin beta-4A chain [KO:K07375]
129081661  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
129070405  TUBB1; tubulin beta-1 chain [KO:K07375]
129085542  LOW QUALITY PROTEIN: tubulin beta-2B chain-like [KO:K07375]
129085543  LOW QUALITY PROTEIN: tubulin beta-2A chain-like [KO:K07375]
129079143  TUBB4B; tubulin beta-4B chain [KO:K07375]
129067295  TUBB; tubulin beta chain [KO:K07375]
129068170  TUBB3; tubulin beta-3 chain [KO:K07375]
129069640  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129075298  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
129070794  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
129080585  LOW QUALITY PROTEIN: casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
129067313  CSNK2B; casein kinase II subunit beta [KO:K03115]
129080496  BDNF; brain-derived neurotrophic factor [KO:K04355]
129086806  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
129075816  DCTN2; dynactin subunit 2 [KO:K10424]
129078196  DCTN3; dynactin subunit 3 [KO:K10425]
129084713  LOW QUALITY PROTEIN: dynactin subunit 4-like [KO:K10426]
129064989  LOW QUALITY PROTEIN: dynactin subunit 4-like [KO:K10426]
129066541  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
129076735  DCTN5; dynactin subunit 5 [KO:K10427]
129075435  dynactin subunit 6-like [KO:K10428]
129064843  DCTN6; dynactin subunit 6 isoform X1 [KO:K10428]
129077142  ACTR1A; alpha-centractin [KO:K16575]
129080567  ACTR1B; beta-centractin [KO:K16575]
129066002  ACTR10; actin-related protein 10 [KO:K16576]
129086958  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
129088328  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
129068798  DNAH9; dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
129063490  DNAH11; dynein axonemal heavy chain 11 isoform X1 [KO:K10408]
129076756  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
129065458  DNAH7; LOW QUALITY PROTEIN: dynein axonemal heavy chain 7 [KO:K10408]
129072179  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
129086518  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
129073091  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
129073944  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
129087185  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
129067435  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
129061083  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
129074717  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
129069062  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
129078474  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
129086435  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
129065907  DNAL1; dynein axonemal light chain 1 isoform X1 [KO:K10411]
129077931  DNAL4; dynein axonemal light chain 4 [KO:K10412]
129062638  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129068934  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129069869  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129066548  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129068584  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
129072993  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
129070131  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
129086762  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
129077317  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
129069808  DKK1; dickkopf-related protein 1 [KO:K02165]
129085305  DKK2; dickkopf-related protein 2 [KO:K02165]
129084670  WNT1; proto-oncogene Wnt-1 [KO:K03209]
129063195  WNT2; protein Wnt-2 [KO:K00182]
129063930  WNT2B; protein Wnt-2b [KO:K00182]
129071521  WNT3; proto-oncogene Wnt-3 [KO:K00312]
129079093  WNT3A; protein Wnt-3a [KO:K00312]
129068971  WNT4; protein Wnt-4 [KO:K00408]
129088518  WNT5A; protein Wnt-5a [KO:K00444]
129073424  WNT5B; protein Wnt-5b [KO:K00444]
129080635  WNT6; protein Wnt-6 [KO:K00445]
129077914  WNT7B; protein Wnt-7b [KO:K00572]
129071686  WNT7A; protein Wnt-7a [KO:K00572]
129077118  WNT8B; protein Wnt-8b [KO:K00714]
129066317  WNT8A; protein Wnt-8a [KO:K00714]
129071596  WNT9B; protein Wnt-9b [KO:K01064]
129079070  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
129084671  WNT10B; protein Wnt-10b [KO:K01357]
129080634  WNT10A; protein Wnt-10a [KO:K01357]
129072640  WNT11; protein Wnt-11 [KO:K01384]
129062854  WNT16; protein Wnt-16 [KO:K01558]
129063044  FZD1; frizzled-1 [KO:K02432]
129080422  FZD7; frizzled-7 [KO:K02432]
129086682  FZD2; frizzled-2 [KO:K02235]
129072540  FZD3; frizzled-3 [KO:K02329]
129072819  FZD4; frizzled-4 [KO:K02354]
129086008  FZD8; frizzled-8 [KO:K02375]
129080389  FZD5; frizzled-5 [KO:K02375]
129084260  FZD6; frizzled-6 isoform X1 [KO:K02376]
129083423  FZD9; frizzled-9 [KO:K02842]
129087122  FZD10; frizzled-10 [KO:K02842]
129068530  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
129085017  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
129077820  CSNK1E; casein kinase I [KO:K08960] [EC:2.7.11.1]
129077014  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
129072308  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
129079202  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
129077272  FRAT1; proto-oncogene FRAT1 [KO:K03069]
129077273  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
129081256  AXIN1; axin-1 isoform X1 [KO:K02157]
129070231  AXIN2; axin-2 isoform X1 [KO:K04385]
129081677  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
129083908  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
129088214  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
129066556  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
129073328  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
129067344  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129065223  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129062984  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129069623  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
129065274  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
129072826  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
129068571  RELA; transcription factor p65 [KO:K04735]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129070278  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
129081870  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
129063428  IL6; interleukin-6 [KO:K05405]
129072125  IL1A; interleukin-1 alpha [KO:K04383]
129072126  IL1B; interleukin-1 beta [KO:K04519]
129063699  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
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Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
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Int J Mol Sci 21:E2108 (2020)
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Reference
PMID:24619348
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Hetz C, Mollereau B
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Reference
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Reference
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Reference
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Reference
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Reference
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  Title
Regulation of Axonal Transport by Protein Kinases.
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Trends Biochem Sci 40:597-610 (2015)
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Reference
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Axonal transport deficits and neurodegenerative diseases.
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Reference
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Axonal transport and neurological disease.
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Reference
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Retrograde axonal transport: pathways to cell death?
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Trends Neurosci 33:335-44 (2010)
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Related
pathway
ppam00190  Oxidative phosphorylation
ppam03050  Proteasome
ppam04020  Calcium signaling pathway
ppam04120  Ubiquitin mediated proteolysis
ppam04137  Mitophagy - animal
ppam04140  Autophagy - animal
ppam04141  Protein processing in endoplasmic reticulum
ppam04142  Lysosome
ppam04210  Apoptosis
ppam04310  Wnt signaling pathway
ppam04724  Glutamatergic synapse
ppam04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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