KEGG   PATHWAY: rtem04010
Entry
rtem04010                   Pathway                                
Name
MAPK signaling pathway - Rana temporaria (common frog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
rtem04010  MAPK signaling pathway
rtem04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Rana temporaria (common frog) [GN:rtem]
Gene
120908962  [KO:K08774]
120909050  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
120909054  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120909277  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120909484  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
120910419  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
120912131  [KO:K04372] [EC:2.7.11.1]
120912951  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120913037  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120913180  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120913186  FLNA; filamin-A isoform X1 [KO:K04437]
120913274  TNF; tumor necrosis factor [KO:K03156]
120913286  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
120913289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120913378  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
120913404  RASGRP4; RAS guanyl-releasing protein 4 [KO:K04350]
120913409  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
120913507  [KO:K03283]
120913561  RELB; transcription factor RelB [KO:K09253]
120913612  EFNA2; ephrin-A2 [KO:K05462]
120913680  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
120913770  [KO:K05096] [EC:2.7.10.1]
120913885  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120913974  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
120913987  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120914048  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120914229  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120914309  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
120914385  FGF5; fibroblast growth factor 5 [KO:K04358]
120915040  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120915288  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
120915289  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
120915290  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
120915291  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120915329  NTF4; neurotrophin-4 [KO:K12457]
120915621  CDC42; LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
120915681  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120915815  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120915924  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
120916079  FGF21; fibroblast growth factor 21 [KO:K22429]
120916187  JUND; transcription factor jun-D [KO:K04449]
120916435  [KO:K03283]
120916440  NRTN; neurturin [KO:K25414]
120916501  RRAS; ras-related protein R-Ras [KO:K07830]
120916507  [KO:K13769]
120916543  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120916577  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
120916588  [KO:K07827]
120916800  AREG; amphiregulin [KO:K09782]
120916802  EREG; proepiregulin [KO:K09784]
120916813  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
120916816  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
120916862  FGF4; fibroblast growth factor 4 [KO:K04358]
120916863  FGF19; fibroblast growth factor 19 [KO:K22603]
120917022  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
120917068  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
120917106  FGF3; fibroblast growth factor 3 [KO:K04358]
120917118  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
120917211  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
120917285  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120917286  INS; insulin [KO:K04526]
120917310  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
120917364  HRAS; GTPase HRas [KO:K02833]
120917518  RELA; transcription factor p65 isoform X1 [KO:K04735]
120917567  [KO:K16510] [EC:2.7.11.1]
120917625  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120917675  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
120917738  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120918364  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120918414  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120918419  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
120918450  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120918453  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120918634  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120918752  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
120918763  FGF2; fibroblast growth factor 2 [KO:K18497]
120918777  [KO:K04380]
120918821  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
120918867  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120918896  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
120918911  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
120919063  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120919124  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120919144  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120919202  [KO:K04411]
120919232  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120919516  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
120919584  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120920186  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
120920251  PDGFC; platelet-derived growth factor C [KO:K05450]
120920284  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
120920339  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120920363  [KO:K05462]
120920381  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
120920477  PEA15; astrocytic phosphoprotein PEA-15 [KO:K29115]
120920649  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
120920685  SOS2; son of sevenless homolog 2 [KO:K03099]
120920783  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120920799  [KO:K16342] [EC:3.1.1.4]
120920861  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
120920881  MAX; protein max isoform X1 [KO:K04453]
120920948  [KO:K16342] [EC:3.1.1.4]
120920953  [KO:K05462]
120921090  VEGFC; vascular endothelial growth factor C [KO:K05449]
120921142  [KO:K16342] [EC:3.1.1.4]
120921188  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
120921481  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
120921507  [KO:K02187] [EC:3.4.22.56]
120921899  FGF16; fibroblast growth factor 16 [KO:K04358]
120922384  FGF20; fibroblast growth factor 20 [KO:K04358]
120922623  [KO:K03283]
120922715  [KO:K04373] [EC:2.7.11.1]
120922871  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120922887  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
120922903  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
120923787  [KO:K07830]
120924362  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120924593  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
120924718  [KO:K16342] [EC:3.1.1.4]
120924719  [KO:K16342] [EC:3.1.1.4]
120924720  [KO:K16342] [EC:3.1.1.4]
120926475  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
120926477  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
120926578  NF1; neurofibromin isoform X1 [KO:K08052]
120926707  HSPB1; heat shock protein beta-1 [KO:K04455]
120926973  [KO:K05466]
120927008  NGF; beta-nerve growth factor [KO:K02582]
120927024  NRAS; GTPase NRas [KO:K07828]
120927068  RAP1A; ras-related protein Rap-1A [KO:K04353]
120927097  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
120927104  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
120927158  [KO:K05453]
120927199  STMN1; stathmin isoform X1 [KO:K04381]
120927212  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
120927297  [KO:K04441] [EC:2.7.11.24]
120927375  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120927513  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
120927613  CRK; adapter molecule crk isoform X1 [KO:K04438]
120927629  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120927701  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
120927711  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
120927767  VEGFD; vascular endothelial growth factor D [KO:K05449]
120928074  FGF10; fibroblast growth factor 10 [KO:K04358]
120928311  [KO:K04374]
120928469  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
120928786  [KO:K04439]
120928798  [KO:K03283]
120928800  [KO:K03283]
120928801  [KO:K03283]
120928802  [KO:K03283]
120928803  [KO:K03283]
120928894  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
120929043  PDGFD; platelet-derived growth factor D [KO:K05450]
120929196  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120929198  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
120929231  FGF9; fibroblast growth factor 9 [KO:K04358]
120929334  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
120929463  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
120929532  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120929587  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
120929600  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
120930441  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
120930553  PSPN; persephin [KO:K25416]
120930629  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
120930765  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
120930868  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
120931069  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
120931096  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
120931107  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120931158  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120931322  FGF7; fibroblast growth factor 7 [KO:K04358]
120931552  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
120931570  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
120931732  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
120931733  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
120931826  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120931827  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
120931873  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
120931918  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
120931976  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
120931994  RAP1B; ras-related protein Rap-1b [KO:K07836]
120932056  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120932060  KITLG; kit ligand isoform X1 [KO:K05461]
120932128  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120932197  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
120932271  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120932310  FGF1; fibroblast growth factor 1 [KO:K18496]
120932373  FGF18; fibroblast growth factor 18 [KO:K04358]
120932539  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120932545  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
120932546  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120932629  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
120932647  FGF6; fibroblast growth factor 6 [KO:K04358]
120932709  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
120932711  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120932730  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120932753  KRAS; GTPase KRas isoform X1 [KO:K07827]
120932891  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120932892  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
120932973  TGFA; protransforming growth factor alpha [KO:K08774]
120933040  [KO:K04519]
120933041  [KO:K04519]
120933042  IL1B; interleukin-1 beta [KO:K04519]
120933043  [KO:K04519]
120933142  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
120933164  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120933172  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120933213  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
120933221  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120933227  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120933342  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
120933383  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120933445  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
120933851  TP53; cellular tumor antigen p53 [KO:K04451]
120936184  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120936442  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120936457  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
120936703  CRKL; crk-like protein [KO:K04438]
120936732  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
120936855  [KO:K04723]
120936970  ANGPT2; angiopoietin-2 [KO:K05466]
120937120  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120937349  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120937397  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
120937407  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
120937486  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
120937496  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120937522  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120937779  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
120937881  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120937894  TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376]
120937963  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
120938053  SRF; serum response factor isoform X1 [KO:K04378]
120938083  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120939987  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
120940043  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
120940125  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120940127  [KO:K04421] [EC:2.7.11.25]
120940316  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120940364  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120940517  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120940799  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120941416  STK3; serine/threonine-protein kinase 3 [KO:K04412]
120941457  ANGPT1; angiopoietin-1 [KO:K05465]
120941525  MYC; myc proto-oncogene protein [KO:K04377]
120941557  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120941685  [KO:K02583]
120942448  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
120942977  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
120943047  [KO:K04468] [EC:2.7.11.24]
120943058  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
120943240  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120943296  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120943297  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
120943378  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
120943462  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120943487  [KO:K04392]
120943488  [KO:K04392]
120943838  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
120943988  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
120944004  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
120944109  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
120944245  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
120944255  [KO:K07831]
120944427  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120944847  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
120944854  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120944910  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120944945  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
120944956  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
120945156  [KO:K04441] [EC:2.7.11.24]
120945243  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
120945252  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
120945285  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120945302  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120945303  [KO:K04374]
120945320  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120945338  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
120945372  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120945377  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120945426  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120945539  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120945814  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120945982  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120946042  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120946043  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120946091  JUN; transcription factor AP-1 [KO:K04448]
120946099  [KO:K16342] [EC:3.1.1.4]
120946125  ARTN; artemin [KO:K25415]
120946141  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
120946851  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120947018  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120947029  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120947163  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120947218  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
rtem04020  Calcium signaling pathway
rtem04070  Phosphatidylinositol signaling system
rtem04110  Cell cycle
rtem04115  p53 signaling pathway
rtem04210  Apoptosis
rtem04310  Wnt signaling pathway
KO pathway
ko04010   

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