Entry
Name
MAPK signaling pathway - Rana temporaria (common frog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rana temporaria (common frog) [GN:
rtem ]
Gene
120933383 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
120913885 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
120932711 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
120945252 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
120945814 CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
120913037 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
120918867 CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854 ]
120943240 CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855 ]
120945426 CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
120927212 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
120931732 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
120944945 CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
120945243 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
120932709 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861 ]
120918821 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
120939987 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
120929587 CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
120944109 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
120918419 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
120945338 CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
120943297 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
120918752 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
120918453 CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
120915288 CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871 ]
120915290 CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
120915289 CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873 ]
120946042 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
120918414 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
120947163 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
120933142 PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
120931069 RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349 ]
120930441 RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
120920381 RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
120930868 FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428 ]
120943462 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
120916577 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454 ]
120938083 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
120919124 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
120941685 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
120918896 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
120912131 LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372 ] [EC:2.7.11.1 ]
120945302 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
120937894 TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376 ]
120930928 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
120944854 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
120910419 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
120943487 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
120915621 CDC42; LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393 ]
120917675 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
120940125 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
120946043 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
120912951 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
120941557 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
120945377 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
120937397 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
120933342 ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
120917118 MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434 ]
120931570 MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435 ]
120943378 MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
120940799 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
120916816 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
120943988 ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
120930765 MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
120918364 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
rtem04070 Phosphatidylinositol signaling system
KO pathway
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