KEGG   PATHWAY: sbq04010
Entry
sbq04010                    Pathway                                
Name
MAPK signaling pathway - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
sbq04010  MAPK signaling pathway
sbq04010

Other DBs
GO: 0000165
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101046396  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101049976  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101040048  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101043152  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101040860  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101034685  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101028952  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X14 [KO:K04854]
101029677  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101034125  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101042219  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101053043  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101041145  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101040923  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101038775  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101048339  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
101048438  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X7 [KO:K04863]
101040084  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X2 [KO:K04864]
101031728  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101039173  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101035489  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101040136  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101046332  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101038867  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101031975  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101032298  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101040452  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101042405  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101051683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101046368  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101045514  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101035788  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101032266  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101039659  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104650539  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101037427  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
101041685  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101030982  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101053574  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101043633  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101048039  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101033151  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X8 [KO:K08018]
101034855  NF1; neurofibromin isoform X1 [KO:K08052]
101032122  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101029341  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101048450  RAP1A; ras-related protein Rap-1A [KO:K04353]
101036065  RAP1B; ras-related protein Rap-1b [KO:K07836]
101052478  EGF; pro-epidermal growth factor [KO:K04357]
101045311  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101049173  EREG; proepiregulin [KO:K09784]
101051947  AREG; amphiregulin [KO:K09782]
101040924  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101048161  FGF8; fibroblast growth factor 8 [KO:K04358]
101040388  FGF20; fibroblast growth factor 20 [KO:K04358]
101040926  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101047221  FGF4; fibroblast growth factor 4 [KO:K04358]
101046667  FGF18; fibroblast growth factor 18 [KO:K04358]
101046606  FGF10; fibroblast growth factor 10 [KO:K04358]
101042449  FGF3; fibroblast growth factor 3 [KO:K04358]
101048187  FGF6; fibroblast growth factor 6 [KO:K04358]
101052821  FGF9; fibroblast growth factor 9 [KO:K04358]
101031255  FGF7; fibroblast growth factor 7 [KO:K04358]
101050264  FGF16; fibroblast growth factor 16 [KO:K04358]
101031426  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101047544  FGF19; fibroblast growth factor 19 [KO:K22603]
101048392  FGF21; fibroblast growth factor 21 [KO:K22429]
101048503  FGF23; fibroblast growth factor 23 [KO:K22428]
101038561  NGF; beta-nerve growth factor [KO:K02582]
101037414  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101044487  NTF3; neurotrophin-3 [KO:K04356]
101051884  NTF4; neurotrophin-4 [KO:K12457]
101038116  INS; insulin [KO:K04526]
101036963  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101036519  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
101034511  PDGFA; platelet-derived growth factor subunit A isoform X6 [KO:K04359]
101043776  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101038849  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101049234  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101036115  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101047247  KITLG; kit ligand isoform X1 [KO:K05461]
101030168  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101028762  VEGFB; vascular endothelial growth factor B [KO:K16858]
101042551  PGF; placenta growth factor isoform X1 [KO:K16859]
101044650  FIGF; vascular endothelial growth factor D isoform X1 [KO:K05449]
101048128  VEGFC; vascular endothelial growth factor C [KO:K05449]
101045517  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101040183  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101044719  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
101044031  ANGPT4; angiopoietin-4 [KO:K05467]
101036676  EFNA1; ephrin-A1 [KO:K05462]
101030990  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101036352  EFNA3; ephrin-A3 [KO:K05462]
104652862  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101034000  EFNA2; ephrin-A2 [KO:K05462]
101037236  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101046260  NRTN; neurturin [KO:K25414]
101053569  ARTN; artemin [KO:K25415]
101043055  LOW QUALITY PROTEIN: persephin [KO:K25416]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101043415  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101030064  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101049355  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101033213  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101033845  FGFR2; fibroblast growth factor receptor 2 isoform X11 [KO:K05093] [EC:2.7.10.1]
101051421  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101027585  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101047376  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101035626  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101053284  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
101028986  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
101039763  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101040158  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101043573  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101037282  KIT; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101027591  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101053773  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101033672  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101036336  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101038696  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
101039223  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101043888  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101053966  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101032806  RRAS; ras-related protein R-Ras [KO:K07829]
101034979  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101053335  MRAS; ras-related protein M-Ras [KO:K07831]
101043605  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101052142  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101037912  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101053960  MKNK2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101044769  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
101045905  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101047213  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101045276  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
101035085  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101034435  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101045005  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101035410  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101031422  SRF; serum response factor [KO:K04378]
101046701  FOS; proto-oncogene c-Fos [KO:K04379]
101029753  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
101053762  STMN1; stathmin [KO:K04381]
101038256  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101054434  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101036859  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101037291  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101037621  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101033360  IL1A; interleukin-1 alpha [KO:K04383]
101033664  IL1B; interleukin-1 beta [KO:K04519]
101047980  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
101044624  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101048819  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
104649955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
101031937  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101040233  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101030583  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101034142  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101035660  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101035635  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101051835  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101029481  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101046124  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101050895  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101050794  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101035434  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101045835  DAXX; death domain-associated protein 6 [KO:K02308]
101052794  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101052342  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101029005  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101033308  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101030208  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101039106  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101047513  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101041553  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
101040230  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101033133  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
101043945  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101038896  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101049413  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101042666  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101035351  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101046861  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101044498  STK3; serine/threonine-protein kinase 3 [KO:K04412]
101030997  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101046566  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101054366  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101039966  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101035799  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101035755  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X2 [KO:K04421] [EC:2.7.11.25]
101043439  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
101051154  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101038631  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101052309  mitogen-activated protein kinase kinase kinase MLK4 isoform X2 [KO:K17534] [EC:2.7.11.25]
101031938  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101049991  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
101043045  mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
101038273  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
101034123  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101045636  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101042401  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101032004  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101032953  TAOK2; serine/threonine-protein kinase TAO2 isoform X3 [KO:K04429] [EC:2.7.11.1]
101034231  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101037589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101047840  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101034633  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101030219  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101035081  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101054291  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101031887  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
101038946  FLNA; filamin-A isoform X1 [KO:K04437]
101051048  CRKL; crk-like protein [KO:K04438]
101029260  CRK; adapter molecule crk [KO:K04438]
101037722  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101046584  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101046534  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
101052249  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101035301  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101047847  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101051225  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101033653  CDC25B; M-phase inducer phosphatase 2 isoform X3 [KO:K05866] [EC:3.1.3.48]
101040060  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101043809  JUN; transcription factor AP-1 [KO:K04448]
101035834  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
104651132  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101027820  MAX; protein max isoform X2 [KO:K04453]
101029713  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101031388  HSPB1; heat shock protein beta-1 [KO:K04455]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101039878  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101047675  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
101051113  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101052187  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
101043469  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101037946  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101047987  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101027516  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101039861  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101029060  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101029870  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101048106  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101031044  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101040682  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101040231  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101028247  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101030095  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101049152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101049467  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101032912  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101050736  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101051357  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X6 [KO:K04462] [EC:2.1.1.367]
101037814  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101050659  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
101039973  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101044826  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101044006  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101052971  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101043425  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101042695  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101027608  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101035406  RELA; transcription factor p65 [KO:K04735]
101051249  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Related
pathway
sbq04070  Phosphatidylinositol signaling system
sbq04110  Cell cycle
sbq04115  p53 signaling pathway
sbq04210  Apoptosis
sbq04310  Wnt signaling pathway
sbq04668  TNF signaling pathway
KO pathway
ko04010   
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