KEGG   PATHWAY: sdu04010
Entry
sdu04010                    Pathway                                
Name
MAPK signaling pathway - Seriola dumerili (greater amberjack)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
sdu04010  MAPK signaling pathway
sdu04010

Other DBs
GO: 0000165
Organism
Seriola dumerili (greater amberjack) [GN:sdu]
Gene
111235833  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
111227043  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
111221156  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111227530  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111224579  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111220529  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111222823  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111240381  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
111230977  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
111234857  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
111235435  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
111219652  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
111216922  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04856]
111235868  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111226995  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111219219  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111221701  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111224485  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
111228383  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
111222853  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
111222860  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
111219056  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
111222914  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
111224495  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
111235963  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
111217509  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111237821  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111231115  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
111217370  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
111218998  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
111218646  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
111239914  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
111229419  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111227239  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
111217600  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
111235889  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
111216550  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
111230283  cacng3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
111229328  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111227134  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
111229473  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111227236  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111233249  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
111230163  voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871]
111230120  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
111233246  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
111230128  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
111233238  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
111220870  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111229212  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111227008  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111227115  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
111236289  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111216674  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
111230195  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
111230118  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
111216573  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
111232040  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
111227309  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
111229048  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111231600  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111226639  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111238025  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111228063  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111234460  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111227385  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111237590  calcineurin subunit B type 1-like [KO:K06268]
111221017  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111228529  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
111237760  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
111216984  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
111225600  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111226917  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
111236432  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
111232429  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111235142  nf1; neurofibromin [KO:K08052]
111226968  rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
111224060  rasa2; ras GTPase-activating protein 2 [KO:K08053]
111224024  ras-related protein Rap-1A-like [KO:K04353]
111234902  ras-related protein Rap-1A [KO:K04353]
111225046  rap1b; ras-related protein Rap-1b [KO:K07836]
111232468  egf; pro-epidermal growth factor [KO:K04357]
111222913  cell wall integrity and stress response component 1-like [KO:K08774]
111236526  ereg; proepiregulin [KO:K09784]
111236451  areg; amphiregulin [KO:K09782]
111236452  amphiregulin-like [KO:K09782]
111226537  putative fibroblast growth factor 1 [KO:K18496]
111234449  putative fibroblast growth factor 1 [KO:K18496]
111232376  fgf2; fibroblast growth factor 2 [KO:K18497]
111225248  fgf6; fibroblast growth factor 6 [KO:K04358]
111224824  fibroblast growth factor 6-like [KO:K04358]
111221801  fgf4; fibroblast growth factor 4 [KO:K04358]
111219490  fgf3; fibroblast growth factor 3 [KO:K04358]
111220642  fibroblast growth factor 8 isoform X1 [KO:K04358]
111226673  fibroblast growth factor 20-like [KO:K04358]
111226700  fgf16; fibroblast growth factor 16 [KO:K04358]
111232662  fibroblast growth factor 18-like [KO:K04358]
111238669  fgf7; fibroblast growth factor 7 [KO:K04358]
111234149  fibroblast growth factor 10-like [KO:K04358]
111228103  fibroblast growth factor 4A-like [KO:K04358]
111229105  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111232136  fgf22; fibroblast growth factor 22 [KO:K04358]
111229280  fibroblast growth factor 8b-like [KO:K04358]
111236454  fgf10; fibroblast growth factor 10 [KO:K04358]
111229366  fibroblast growth factor 20-like [KO:K04358]
111228003  fgf5; fibroblast growth factor 5 [KO:K04358]
111239442  fibroblast growth factor 18-like [KO:K04358]
111230392  fibroblast growth factor 4-like [KO:K04358]
111221755  fgf19; fibroblast growth factor 19 isoform X1 [KO:K22603]
111219763  fgf21; fibroblast growth factor 21 [KO:K22429]
111225015  fgf23; fibroblast growth factor 23 [KO:K22428]
111225236  fibroblast growth factor 23-like [KO:K22428]
111218944  nerve growth factor-like [KO:K02582]
111219495  nerve growth factor-like [KO:K02582]
111238401  bdnf; brain-derived neurotrophic factor [KO:K04355]
111224893  ntf3; neurotrophin-3 [KO:K04356]
111221377  ins; insulin [KO:K04526]
111226678  insulin-like [KO:K04526]
111234582  insulin-like [KO:K04526]
111225018  igf1; insulin-like growth factor I [KO:K05459]
111233786  insulin-like growth factor I [KO:K05459]
111228384  igf2; insulin-like growth factor II [KO:K13769]
111216525  platelet-derived growth factor subunit A-like [KO:K04359]
111227111  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
111216519  uncharacterized protein LOC111216519 [KO:K17386]
111224145  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
111232625  pdgfc; platelet-derived growth factor C [KO:K05450]
111222528  kitlg; kit ligand [KO:K05461]
111227814  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
111238405  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111225931  pgf; placenta growth factor [KO:K16859]
111240400  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
111224831  vegfd; vascular endothelial growth factor D [KO:K05449]
111236702  vascular endothelial growth factor C-like [KO:K05449]
111230477  vegfc; vascular endothelial growth factor C [KO:K05449]
111224573  hepatocyte growth factor-like [KO:K05460]
111228480  hgf; hepatocyte growth factor [KO:K05460]
111223018  angpt1; angiopoietin-1 [KO:K05465]
111224380  angiopoietin-4-like [KO:K05465]
111223000  angiopoietin-2-like [KO:K05466]
111234960  angpt2; angiopoietin-2 isoform X1 [KO:K05466]
111221222  ephrin-A5b-like [KO:K05462]
111223198  ephrin-A1-like isoform X1 [KO:K05462]
111236208  ephrin-A2-like [KO:K05462]
111230925  efna5; ephrin-A5 [KO:K05462]
111230147  efna1; ephrin-A1 [KO:K05462]
111230153  ephrin-A4-like [KO:K05462]
111226056  ephrin-A2-like [KO:K05462]
111230174  efna3; ephrin-A3 [KO:K05462]
111230929  glial cell line-derived neurotrophic factor-like [KO:K05452]
111234245  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
111231228  nrtn; neurturin [KO:K25414]
111229091  uncharacterized protein LOC111229091 [KO:K25415]
111235871  persephin-like [KO:K25416]
111237405  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111231258  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111219739  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111219064  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
111221725  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111218871  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111233771  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111224260  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
111226297  tyrosine kinase receptor Cad96Ca-like [KO:K04362] [EC:2.7.10.1]
111226155  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
111220545  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111226196  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111234275  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
111217770  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111220001  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111236770  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111222591  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111239875  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
111230804  ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
111231251  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111237924  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111217738  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111228731  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111226338  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
111226471  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111239485  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
111226429  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
111239498  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
111231521  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
111226336  kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
111220948  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
111221028  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111232404  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111226519  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111226355  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111220524  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111227591  epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
111222863  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
111220596  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111238087  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111225570  sos2; son of sevenless homolog 2 [KO:K03099]
111237578  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
111228382  hras; GTPase HRas [KO:K02833]
111228455  kras; GTPase KRas isoform X1 [KO:K07827]
111230220  GTPase HRas-like [KO:K07827]
111227963  rras; ras-related protein R-Ras [KO:K07830]
111236562  rras2; ras-related protein R-Ras2 [KO:K07830]
111218153  mras; ras-related protein M-Ras [KO:K07831]
111227828  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
111224636  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
111217320  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111228471  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111232170  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111229041  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111225558  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
111236845  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111230214  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111230850  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111232172  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
111225371  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111218098  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
111226530  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111238290  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111216707  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
111230364  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
111235429  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
111221656  ETS domain-containing protein Elk-4-like isoform X1 [KO:K04376]
111239852  transcriptional regulator Myc-like isoform X1 [KO:K04377]
111237873  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
111238287  transcriptional regulator Myc-2-like [KO:K04377]
111220538  srf; serum response factor isoform X1 [KO:K04378]
111237574  serum response factor-like isoform X1 [KO:K04378]
111216358  proto-oncogene c-Fos-like [KO:K04379]
111225857  proto-oncogene c-Fos-like [KO:K04379]
111239160  proto-oncogene c-Fos-like [KO:K04379]
111219558  microtubule-associated protein tau-like isoform X1 [KO:K04380]
111239803  microtubule-associated protein tau-like [KO:K04380]
111232890  stathmin-like [KO:K04381]
111228162  stathmin-like [KO:K04381]
111217737  pla2g4c; LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
111232269  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
111220854  tumor necrosis factor-like [KO:K03156]
111222585  tumor necrosis factor-like [KO:K03156]
111239668  interleukin-1 beta-like [KO:K04519]
111227981  interleukin-1 beta-like [KO:K04519]
111227984  interleukin-1 beta-like [KO:K04519]
111216899  transforming growth factor beta-1-like [KO:K13375]
111232504  transforming growth factor beta-2-like [KO:K13376]
111227872  tgfb2; transforming growth factor beta-2 [KO:K13376]
111225435  tgfb3; transforming growth factor beta-3 [KO:K13377]
111238468  transforming growth factor beta-3-like [KO:K13377]
111230077  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
111218164  interleukin-1 receptor type 1-like [KO:K04386]
111218892  interleukin-1 receptor type 1-like [KO:K04386]
111218165  interleukin-1 receptor type 1-like [KO:K04386]
111216885  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
111220510  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111223506  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111237959  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111225824  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111232361  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111232053  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111235178  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
111220230  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111227294  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111235860  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111237036  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111221873  cell division control protein 42 homolog isoform X1 [KO:K04393]
111234891  cell division control protein 42 homolog isoform X1 [KO:K04393]
111230104  cell division control protein 42 homolog [KO:K04393]
111233205  cell division control protein 42 homolog [KO:K04393]
111221183  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111216621  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111226544  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111217845  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111240026  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
111229789  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111220913  daxx; death domain-associated protein 6 [KO:K02308]
111220968  myeloid differentiation primary response protein MyD88-like [KO:K04729]
111235426  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
111229598  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
111223588  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111221205  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111221204  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111231824  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
111232041  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111228873  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
111230864  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111226142  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
111235905  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111216386  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111223616  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
111227400  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
111237581  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
111238731  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111226586  misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
111218152  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
111216915  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111225480  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
111226340  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111224361  serine/threonine-protein kinase 4-like [KO:K04411]
111223193  serine/threonine-protein kinase 3 [KO:K04412]
111223611  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
111228231  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
111226905  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
111222725  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111217593  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
111221016  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
111225561  mitogen-activated protein kinase kinase kinase 9-like [KO:K04417] [EC:2.7.11.25]
111238128  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
111235336  mitogen-activated protein kinase kinase kinase 21-like [KO:K17534] [EC:2.7.11.25]
111217270  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
111223920  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
111218550  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111218353  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111228953  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
111235736  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
111237351  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
111238781  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111226008  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
111234458  map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
111217067  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
111227354  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
111232240  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
111238857  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
111234170  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
111220395  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
111217504  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
111219937  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
111236339  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111219741  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
111227238  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
111222978  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
111229840  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
111228593  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
111230192  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
111237012  filamin-A-like isoform X1 [KO:K04437]
111238220  adapter molecule crk-like [KO:K04438]
111233069  crkl; crk-like protein [KO:K04438]
111233089  adapter molecule crk-like [KO:K04438]
111216914  beta-arrestin-1 isoform X1 [KO:K04439]
111221328  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
111223644  arrestin red cell-like [KO:K04439]
111219534  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
111226417  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111234720  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111235092  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111225013  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
111224692  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111218919  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111221298  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111221706  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111227590  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111228380  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111230770  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
111217307  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
111221767  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111221682  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
111221435  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
111225707  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
111222169  ribosomal protein S6 kinase alpha-4-like isoform X1 [KO:K16510] [EC:2.7.11.1]
111226000  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
111220887  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111227860  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111218909  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111235968  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111228982  jun; transcription factor AP-1 [KO:K04448]
111231968  transcription factor AP-1-like isoform X1 [KO:K04448]
111217203  jund; transcription factor jun-D [KO:K04449]
111228853  transcription factor jun-D-like [KO:K04449]
111218870  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
111233015  cellular tumor antigen p53-like isoform X1 [KO:K04451]
111223952  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
111238651  max; protein max isoform X1 [KO:K04453]
111226078  protein max-like isoform X1 [KO:K04453]
111226410  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111224262  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
111222268  hspb1; heat shock protein beta-1 [KO:K04455]
111234199  heat shock protein beta-1-like [KO:K04455]
111225465  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111238251  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111235389  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111234315  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111233400  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111225333  ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
111238888  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
111234419  protein phosphatase 1B-like [KO:K04457] [EC:3.1.3.16]
111224965  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
111228477  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
111235453  ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
111226686  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111217387  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111223964  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111229521  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111237732  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111227967  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111237491  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111229191  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111228433  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111222512  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111216368  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111220455  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111223778  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111216783  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111219773  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
111235241  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
111219259  heat shock 70 kDa protein-like [KO:K03283]
111222149  heat shock cognate 71 kDa protein-like [KO:K03283]
111238863  heat shock 70 kDa protein 1 [KO:K03283]
111222401  heat shock cognate 71 kDa protein [KO:K03283]
111235505  heat shock 70 kDa protein 1-like [KO:K03283]
111234021  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
111224094  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
111238645  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111220321  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
111221484  probable nuclear hormone receptor HR38 [KO:K04465]
111234938  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
111217746  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111219576  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111220255  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111234378  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111236497  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111236982  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111238858  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
111235138  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
111233505  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
111224192  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111226894  rela; transcription factor p65 isoform X1 [KO:K04735]
111238158  transcription factor RelB homolog isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
sdu04070  Phosphatidylinositol signaling system
sdu04110  Cell cycle
sdu04115  p53 signaling pathway
sdu04210  Apoptosis
sdu04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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