Entry
Name
MAPK signaling pathway - Sinocyclocheilus rhinocerous
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Sinocyclocheilus rhinocerous [GN:
srx ]
Gene
107723201 LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107737248 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107751115 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107737767 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344 ]
107709695 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107757972 LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107739705 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
107732972 voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850 ]
107711792 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851 ]
107730640 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851 ]
107751208 voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851 ]
107743249 voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851 ]
107707593 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107705142 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107708577 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107757983 cacna1e; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852 ]
107755285 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
107731232 LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853 ]
107723069 LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
107756819 LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
107745766 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853 ]
107743785 LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854 ]
107754113 voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854 ]
107720044 cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855 ]
107738000 voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855 ]
107705872 cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
107718925 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107706663 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107733827 voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856 ]
107711920 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857 ]
107707674 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857 ]
107723934 voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858 ]
107738810 voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858 ]
107732991 voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858 ]
107738419 voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858 ]
107707259 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107720977 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107744381 LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
107751209 voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860 ]
107743247 voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860 ]
107750816 voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860 ]
107716619 voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
107738821 LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
107753542 voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861 ]
107755015 voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862 ]
107745946 voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862 ]
107745300 voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863 ]
107751551 voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04863 ]
107728655 cacnb2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863 ]
107713974 voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04863 ]
107705735 voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864 ]
107716190 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864 ]
107724200 voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864 ]
107745477 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864 ]
107741900 voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
107748538 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865 ]
107714393 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865 ]
107705621 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865 ]
107716892 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107724731 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107710155 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107713948 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
107705909 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107729558 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107737984 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
107719973 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
107725370 cacng3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868 ]
107710002 voltage-dependent calcium channel gamma-3 subunit-like isoform X1 [KO:K04868 ]
107716888 voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869 ]
107724746 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
107713946 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
107710696 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107716884 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107729207 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
107724075 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107724866 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107739513 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
107744303 voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871 ]
107724112 voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872 ]
107739516 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107744304 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107724890 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
107724111 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107735192 voltage-dependent calcium channel gamma-8 subunit-like [KO:K04873 ]
107724881 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107739619 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107744302 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
107724953 voltage-dependent calcium channel gamma-8 subunit-like [KO:K04873 ]
107758336 guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346 ]
107716954 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107733896 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107753760 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107705318 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
107720725 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107743942 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107715410 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107758531 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107733504 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107705087 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107721549 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107709853 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107709805 ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349 ]
107715192 ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349 ]
107756301 ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326 ]
107720279 ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
107751733 ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326 ]
107755973 LOW QUALITY PROTEIN: ras guanyl-releasing protein 3-like [KO:K12362 ]
107756462 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107758567 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107745058 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107750423 rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018 ]
107716439 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
107718638 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
107753752 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
107720370 adenylate cyclase, terminal-differentiation specific-like [KO:K17386 ]
107736246 putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 [KO:K17386 ]
107725277 vascular endothelial growth factor A-A-like isoform X1 [KO:K05448 ]
107726022 vascular endothelial growth factor A-A-like isoform X1 [KO:K05448 ]
107710132 vascular endothelial growth factor A-A-like isoform X1 [KO:K05448 ]
107743178 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107745659 tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583 ]
107755083 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107752834 tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583 ]
107753306 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107708544 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
107727064 sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099 ]
107705915 cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374 ]
107737987 cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374 ]
107744685 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
107748890 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
107712839 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107739860 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
107715957 tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390 ]
107744555 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
107732889 ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
107750529 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
107741433 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
107758293 myeloid differentiation primary response protein MyD88-like [KO:K04729 ]
107741019 myeloid differentiation primary response protein MyD88 [KO:K04729 ]
107711842 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107716939 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107733895 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107724875 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107706329 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107747145 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107743369 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107738256 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107705317 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
107706448 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107757925 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
107708506 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107708507 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
107737983 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
107708311 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
107739913 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
107735497 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405 ]
107708967 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405 ]
107708515 LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414 ] [EC:2.7.11.1 ]
107745293 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107726184 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107714081 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107707405 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
107710370 C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435 ]
107719965 mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435 ]
107754341 mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
107745855 C-Jun-amino-terminal kinase-interacting protein 3-like isoform X1 [KO:K04436 ]
107739553 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
107748694 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
107723991 nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333 ]
107752456 nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
107740457 nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333 ]
107739459 cyclic AMP-dependent transcription factor ATF-2-like isoform X1 [KO:K04450 ]
107734605 ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452 ]
107749767 nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580 ]
107750338 nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580 ]
107725448 nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
srx04070 Phosphatidylinositol signaling system
KO pathway
LinkDB
All DBs