KEGG   PATHWAY: xco04010
Entry
xco04010                    Pathway                                
Name
MAPK signaling pathway - Xiphophorus couchianus (Monterrey platyfish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
xco04010  MAPK signaling pathway
xco04010

Other DBs
GO: 0000165
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114159632  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
114145343  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114155127  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
114149751  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
114161254  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
114148180  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114135515  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
114150504  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
114146626  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
114141251  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
114141072  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
114151820  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
114159893  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04855]
114145100  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
114152588  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04856]
114159938  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
114148648  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114160855  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
114133417  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
114135049  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
114135771  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
114134914  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
114145353  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
114143095  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
114160961  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
114160070  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
114137042  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
114148398  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
114161884  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
114147959  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
114138204  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
114145380  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114159406  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
114145365  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
114160485  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
114145510  voltage-dependent calcium channel gamma-3 subunit-like isoform X1 [KO:K04868]
114160134  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
114160515  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
114145641  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114144260  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114159852  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
114156593  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
114142255  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
114142375  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
114155962  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
114142329  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
114155961  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
114150831  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114144649  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114146401  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
114159753  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114144259  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114159851  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114145501  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
114159895  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114141948  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
114145506  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
114146970  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
114150888  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
114153347  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114157055  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114154312  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114149406  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114139330  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114137969  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
114143305  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
114159931  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114149382  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
114154958  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
114134217  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
114133467  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
114157439  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114138554  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114139721  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
114133637  nf1; neurofibromin [KO:K08052]
114154589  rasa1; ras GTPase-activating protein 1 [KO:K04352]
114161894  rasa2; ras GTPase-activating protein 2 [KO:K08053]
114135748  ras-related protein Rap-1A-like [KO:K04353]
114140864  ras-related protein Rap-1A [KO:K04353]
114161580  ras-related protein Rap-1b [KO:K07836]
114138665  egf; pro-epidermal growth factor [KO:K04357]
114134863  cell wall integrity and stress response component 1-like [KO:K08774]
114155108  proepiregulin-like [KO:K09784]
114155107  amphiregulin-like [KO:K09782]
114152626  fgf1; fibroblast growth factor 1 [KO:K18496]
114139185  putative fibroblast growth factor 1 [KO:K18496]
114139089  fgf2; fibroblast growth factor 2 [KO:K18497]
114143128  fgf3; fibroblast growth factor 3 [KO:K04358]
114143136  fgf4; fibroblast growth factor 4 [KO:K04358]
114155490  fibroblast growth factor 4-like [KO:K04358]
114154047  fgf5; fibroblast growth factor 5 [KO:K04358]
114150230  fibroblast growth factor 10-like [KO:K04358]
114150449  fibroblast growth factor 10-like [KO:K04358]
114143981  fibroblast growth factor 9-like [KO:K04358]
114154160  fgf10; fibroblast growth factor 10 [KO:K04358]
114154183  fgf17; fibroblast growth factor 17 [KO:K04358]
114143619  fgf7; fibroblast growth factor 7 [KO:K04358]
114144862  fibroblast growth factor 8b-like isoform X1 [KO:K04358]
114138604  fibroblast growth factor 8-like isoform X1 [KO:K04358]
114138676  fgf16; fibroblast growth factor 16 [KO:K04358]
114138797  fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
114139086  fibroblast growth factor 18-like isoform X1 [KO:K04358]
114139226  fibroblast growth factor 20-like [KO:K04358]
114152389  fibroblast growth factor 6-like [KO:K04358]
114160876  fibroblast growth factor 6-like [KO:K04358]
114143132  fgf19; fibroblast growth factor 19 [KO:K22603]
114153231  fibroblast growth factor 21-like [KO:K22429]
114160874  fgf23; fibroblast growth factor 23 [KO:K22428]
114152372  uncharacterized protein LOC114152372 isoform X1 [KO:K22428]
114136304  nerve growth factor [KO:K02582]
114152283  neurotrophin-7-like [KO:K02582]
114142877  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
114161058  ntf3; neurotrophin-3 [KO:K04356]
114153755  ins; insulin isoform X1 [KO:K04526]
114139621  insulin-like [KO:K04526]
114160998  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114142519  insulin-like growth factor I isoform X1 [KO:K05459]
114158858  igf2; insulin-like growth factor II [KO:K13769]
114160156  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114145269  platelet-derived growth factor subunit A-like [KO:K04359]
114145108  uncharacterized protein LOC114145108 [KO:K17386]
114139572  pdgfc; platelet-derived growth factor C [KO:K05450]
114162009  pdgfd; platelet-derived growth factor D [KO:K05450]
114160677  uncharacterized protein LOC114160677 isoform X1 [KO:K05461]
114155967  kit ligand-like [KO:K05461]
114158479  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114139399  vegfb; vascular endothelial growth factor B [KO:K16858]
114158134  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
114134848  placenta growth factor-like [KO:K16859]
114143057  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114145410  vegfc; vascular endothelial growth factor C [KO:K05449]
114140702  vascular endothelial growth factor C-like [KO:K05449]
114161125  hepatocyte growth factor-like isoform X1 [KO:K05460]
114136644  hgf; hepatocyte growth factor [KO:K05460]
114156609  angpt1; angiopoietin-1 [KO:K05465]
114136191  angiopoietin-1-like [KO:K05465]
114138398  angpt2; angiopoietin-2 [KO:K05466]
114156581  angiopoietin-2-like isoform X1 [KO:K05466]
114141838  ephrin-A4-like [KO:K05462]
114156148  ephrin-A1-like isoform X1 [KO:K05462]
114156604  ephrin-A3-like [KO:K05462]
114154220  efna5; ephrin-A5 isoform X1 [KO:K05462]
114149806  ephrin-A5b-like isoform X1 [KO:K05462]
114134163  ephrin-A2-like isoform X1 [KO:K05462]
114142014  ephrin-A3-like isoform X1 [KO:K05462]
114142015  efna1; ephrin-A1 [KO:K05462]
114149078  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114154066  glial cell line-derived neurotrophic factor-like [KO:K05452]
114147219  neurturin-like [KO:K25414]
114145767  uncharacterized protein LOC114145767 [KO:K25415]
114145272  artemin-like [KO:K25416]
114136421  melanoma receptor tyrosine-protein kinase isoform X1 [KO:K04361] [EC:2.7.10.1]
114146596  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114152068  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114146747  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
114135258  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
114140872  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114148479  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
114154182  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114149547  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
114138295  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
114134047  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114159818  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
114152147  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
114142025  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
114141649  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114149964  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
114154115  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114146472  insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
114150578  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
114143064  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114157257  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114151105  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114139478  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114153115  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
114153116  macrophage colony-stimulating factor 1 receptor 2-like isoform X1 [KO:K05090] [EC:2.7.10.1]
114139479  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
114151106  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114144177  mast/stem cell growth factor receptor kita-like isoform X1 [KO:K05091] [EC:2.7.10.1]
114136905  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114136908  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
114136904  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114139259  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
114139113  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114151198  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
114142761  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114144559  epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
114135929  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
114137568  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
114160045  grb2; growth factor receptor-bound protein 2 [KO:K04364]
114134500  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114145177  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114135737  hras; GTPase HRas [KO:K02833]
114156567  kras; GTPase KRas isoform X1 [KO:K07827]
114160036  GTPase HRas-like [KO:K07827]
114147892  ras-related protein R-Ras2-like [KO:K07830]
114143027  rras2; ras-related protein R-Ras2 [KO:K07830]
114148358  mras; ras-related protein M-Ras [KO:K07831]
114154407  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
114161014  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114140577  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114157072  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114151477  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114134838  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
114160039  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114154145  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114151094  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
114150432  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
114134221  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114138894  rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114136428  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114143627  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
114145429  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114159700  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114140996  ETS domain-containing protein Elk-3-like [KO:K04375]
114135669  ETS domain-containing protein Elk-4-like isoform X1 [KO:K04376]
114136008  transcriptional regulator Myc-2-like [KO:K04377]
114137130  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114146318  transcriptional regulator Myc-like isoform X1 [KO:K04377]
114138183  srf; serum response factor isoform X1 [KO:K04378]
114144103  serum response factor-like [KO:K04378]
114158175  proto-oncogene c-Fos-like [KO:K04379]
114158176  proto-oncogene c-Fos-like [KO:K04379]
114133978  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
114160370  microtubule-associated protein tau-like [KO:K04380]
114152030  microtubule-associated protein tau-like isoform X1 [KO:K04380]
114142411  stathmin-like [KO:K04381]
114156456  stathmin-like [KO:K04381]
114150820  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
114148573  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
114156470  tumor necrosis factor-like isoform X1 [KO:K03156]
114149066  interleukin-1 beta-like isoform X1 [KO:K04519]
114153988  interleukin-1 beta-like [KO:K04519]
114155120  interleukin-1 beta-like [KO:K04519]
114161405  transforming growth factor beta-1 proprotein-like [KO:K13375]
114139436  transforming growth factor beta-2 proprotein-like [KO:K13376]
114158174  transforming growth factor beta-3 proprotein-like [KO:K13377]
114134077  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114141624  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114148728  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
114161721  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114149782  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
114145015  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114156140  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114150361  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114139005  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
114137823  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
114151419  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
114151420  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114151421  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114160398  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114144415  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114150885  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114144619  cell division control protein 42 homolog isoform X1 [KO:K04393]
114142284  cell division control protein 42 homolog [KO:K04393]
114156104  cell division control protein 42 homolog [KO:K04393]
114135246  cell division control protein 42 homolog [KO:K04393]
114143776  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114144355  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114139499  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
114149230  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114155101  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114149726  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114156369  death domain-associated protein 6-like isoform X1 [KO:K02308]
114136895  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114140233  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
114158068  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114142760  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114147177  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
114151556  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114155224  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114149816  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114134066  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
114144243  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114158125  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114157515  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
114138308  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114137530  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
114148813  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
114139012  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
114161941  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114133902  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
114150417  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114135604  serine/threonine-protein kinase 4-like [KO:K04411]
114155406  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114157502  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
114137073  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
114157052  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
114140552  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114136809  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
114160172  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
114134112  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
114133159  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
114138146  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
114142698  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
114135267  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
114148301  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
114147068  mitogen-activated protein kinase kinase kinase 7-like [KO:K04424] [EC:2.7.11.25]
114148676  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
114140993  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
114158595  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
114133938  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
114158518  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114137786  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
114152833  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
114152842  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
114154846  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
114149580  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
114159409  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114151734  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
114144382  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114160221  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
114152162  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
114143332  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
114136232  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
114157959  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
114159788  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
114141752  filamin-A-like isoform X1 [KO:K04437]
114149532  crkl; crk-like protein [KO:K04438]
114152956  adapter molecule crk-like [KO:K04438]
114133190  crk; adapter molecule crk isoform X1 [KO:K04438]
114161734  beta-arrestin-1 [KO:K04439]
114153593  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
114151722  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114139131  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114137669  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114150017  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114147906  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114144636  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
114160618  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
114161013  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
114142233  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
114136221  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114135071  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114155243  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
114135726  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114135944  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
114136162  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
114134235  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
114134789  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114156039  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
114145370  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114143167  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114155407  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
114145916  jun; transcription factor AP-1 [KO:K04448]
114151264  transcription factor AP-1-like [KO:K04448]
114151148  jund; transcription factor jun-D [KO:K04449]
114146994  transcription factor jun-D-like [KO:K04449]
114148083  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114157824  tp53; cellular tumor antigen p53 [KO:K04451]
114135476  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114158538  max; protein max isoform X1 [KO:K04453]
114134657  protein max-like [KO:K04453]
114155146  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114149405  myocyte-specific enhancer factor 2C-like [KO:K04454]
114149095  heat shock protein beta-1-like [KO:K04455]
114154092  heat shock protein beta-1-like [KO:K04455]
114152958  hspb1; heat shock protein beta-1 [KO:K04455]
114144319  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114161603  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114137948  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114134115  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114161374  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
114133823  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
114153736  protein phosphatase 1B-like [KO:K04457] [EC:3.1.3.16]
114161185  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
114161670  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
114141096  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
114139363  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114147890  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114155778  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114145403  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114149259  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114153953  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114145292  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114135373  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114160879  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114159540  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114158781  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114148299  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114151903  dusp3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114161404  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
114151970  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
114137520  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114152980  heat shock cognate 70 kDa protein [KO:K03283]
114161475  heat shock cognate 71 kDa protein-like [KO:K03283]
114141833  heat shock cognate 71 kDa protein-like [KO:K03283]
114159417  heat shock 70 kDa protein 1-like [KO:K03283]
114146044  heat shock 70 kDa protein-like [KO:K03283]
114159562  heat shock 70 kDa protein 1 [KO:K03283]
114133278  mecom; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
114143267  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
114134421  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114140408  probable nuclear hormone receptor HR38 [KO:K04465]
114136284  probable nuclear hormone receptor HR38 [KO:K04465]
114160257  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
114151841  uncharacterized protein LOC114151841 [KO:K04466] [EC:2.7.11.25]
114151890  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
114138537  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
114154613  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114140444  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114159563  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
114161830  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
114139461  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114138026  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114157395  transcription factor p65-like isoform X1 [KO:K04735]
114161686  transcription factor RelB-like isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
xco04070  Phosphatidylinositol signaling system
xco04110  Cell cycle
xco04115  p53 signaling pathway
xco04210  Apoptosis
xco04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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