Homo sapiens (human): 2903
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Entry
2903 CDS
T01001
Gene name
GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Definition
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2A
KO
K05209
glutamate receptor ionotropic, NMDA 2A
Organism
hsa
Homo sapiens (human)
Pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04713
Circadian entrainment
hsa04720
Long-term potentiation
hsa04724
Glutamatergic synapse
hsa04728
Dopaminergic synapse
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05031
Amphetamine addiction
hsa05033
Nicotine addiction
hsa05034
Alcoholism
hsa05322
Systemic lupus erythematosus
Network
nt06410
Calcium signaling
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06465
Prion disease
Element
N00970
Transport of calcium
N00971
Mutation-caused aberrant PDYN to transport of calcium
N00987
Mutation-caused aberrant Htt to transport of calcium
N01003
Mutation-caused aberrant Abeta to transport of calcium
N01200
Scrapie conformation PrPSc to transport of calcium
Disease
H01514
Landau-Kleffner syndrome
H01827
Rolandic epilepsy, mental retardation, and speech dyspraxia
Drug target
Acamprosate (
DG00996
):
D02780
<JP/US>
D07058
Amantadine (
DG00860
):
D00777
<JP/US>
D07441
Apimostinel:
D11299
Aptiganel hydrochloride:
D02973
Budipine (
DG00866
):
D07306
D07589
Delucemine hydrochloride:
D03679
Dextromethorphan (
DG01078
):
D00848
<JP>
D03742
D03744
Dextrorphan hydrochloride:
D03746
Dizocilpine maleate:
D03878
Esketamine (
DG01829
):
D07283
D10627
<US>
Felbamate:
D00536
<US>
Gavestinel:
D04308
Ketamine (
DG00796
):
D00711
<JP/US>
D08098
Latrepirdine (
DG01379
):
D09917
D09918
Levomethadone (
DG01002
):
D08121
D08122
Licostinel:
D04728
Memantine (
DG00986
):
D04905
<JP/US>
D08174
Methadone (
DG00999
):
D02102
<JP/US>
D08195
Orphenadrine (
DG01252
):
D08305
Orphenadrine (chloride):
D02599
Orphenadrine (citrate):
D00774
<US>
Perzinfotel:
D05447
Phencyclidine hydrochloride:
D05453
Remacemide hydrochloride:
D05714
Riluzole:
D00775
<JP/US>
Selfotel:
D02410
Tiletamine (
DG01380
):
D06146
D08596
Troriluzole (
DG03011
):
D11414
D11415
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2903 (GRIN2A)
04015 Rap1 signaling pathway
2903 (GRIN2A)
04020 Calcium signaling pathway
2903 (GRIN2A)
04024 cAMP signaling pathway
2903 (GRIN2A)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2903 (GRIN2A)
09150 Organismal Systems
09156 Nervous system
04724 Glutamatergic synapse
2903 (GRIN2A)
04728 Dopaminergic synapse
2903 (GRIN2A)
04720 Long-term potentiation
2903 (GRIN2A)
09159 Environmental adaptation
04713 Circadian entrainment
2903 (GRIN2A)
09160 Human Diseases
09163 Immune disease
05322 Systemic lupus erythematosus
2903 (GRIN2A)
09164 Neurodegenerative disease
05010 Alzheimer disease
2903 (GRIN2A)
05014 Amyotrophic lateral sclerosis
2903 (GRIN2A)
05017 Spinocerebellar ataxia
2903 (GRIN2A)
05020 Prion disease
2903 (GRIN2A)
05022 Pathways of neurodegeneration - multiple diseases
2903 (GRIN2A)
09165 Substance dependence
05030 Cocaine addiction
2903 (GRIN2A)
05031 Amphetamine addiction
2903 (GRIN2A)
05033 Nicotine addiction
2903 (GRIN2A)
05034 Alcoholism
2903 (GRIN2A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
2903 (GRIN2A)
Ion channels [BR:
hsa04040
]
Ligand-gated channels
Glutamate (ionotropic)
2903 (GRIN2A)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
NMDAR2_C
Lig_chan
Lig_chan-Glu_bd
SBP_bac_3
ANF_receptor
Motif
Other DBs
NCBI-GeneID:
2903
NCBI-ProteinID:
NP_000824
OMIM:
138253
HGNC:
4585
Ensembl:
ENSG00000183454
Vega:
OTTHUMG00000129721
Pharos:
Q12879
(Tclin)
UniProt:
Q12879
Q547U9
LinkDB
All DBs
Structure
PDB:
5H8F
5H8Q
5KCJ
5I2N
5H8H
5TP9
5KDT
5TPA
5H8N
5I2K
6IRA
6IRF
6IRG
6IRH
Thumbnails
Position
16p13.2
AA seq
1464 aa
AA seq
DB search
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV
NT seq
4395 nt
NT seq
+upstream
nt +downstream
nt
atgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggt
ccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctg
ggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcg
gcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaag
agcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgttt
ggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacacc
ttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccg
acgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaag
atcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctac
agggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatg
cagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaag
aagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctg
agtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttg
gtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcc
tacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaacc
accgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgc
tacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaat
gttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccagg
ctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaac
catacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgag
ccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaa
gacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtc
aaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgc
attgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtg
accaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtg
gtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaa
gtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagt
aatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatg
atgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagc
cctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttaca
attggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccag
aatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcata
ttcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggac
caagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccacctttt
cgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctac
atgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctg
aaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctggg
agggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggt
tatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgctt
cagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgc
cacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgta
ttctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctc
ttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctc
ttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaag
aagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtca
gccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaaga
gctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaat
ttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatg
aacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattc
cagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtg
agcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattcc
atacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagag
aataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgac
atttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccac
aaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgag
gtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactata
gatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgacc
ctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaag
ggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaac
aacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcac
agtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaac
atgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctg
cggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacaggtaaccca
gccaccggggagcaggtctaccagcaggactgggcacagaacaatgcccttcaattacaa
aagaacaagctaaggattagccgtcagcattcctacgataacattgtcgacaaacctagg
gagctagaccttagcaggccctcccggagcataagcctcaaggacagggaacggcttctg
gagggaaatttttacggcagcctgtttagtgtcccctcaagcaaactctcggggaaaaaa
agctcccttttcccccaaggtctggaggacagcaagaggagcaagtctctcttgccagac
cacacctccgataaccctttcctccactcccacagggatgaccaacgcttggttattggg
agatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctat
cttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaat
gatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactct
acccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatc
gaatctgatgtttaa
DBGET
integrated database retrieval system
