Homo sapiens (human): 3815
Entry
3815 CDS
T01001
Gene name
KIT, C-Kit, CD117, MASTC, PBT, SCFR
Definition
(RefSeq) KIT proto-oncogene, receptor tyrosine kinase
KO
K05091
proto-oncogene tyrosine-protein kinase Kit [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04640
Hematopoietic cell lineage
hsa04916
Melanogenesis
hsa05200
Pathways in cancer
hsa05221
Acute myeloid leukemia
hsa05224
Breast cancer
hsa05230
Central carbon metabolism in cancer
Network
nt06210
ERK signaling
nt06214
PI3K signaling
nt06275
Acute myeloid leukemia
Element
N00003
Mutation-activated KIT to RAS-ERK signaling pathway
N00045
KITLG-KIT-PI3K signaling pathway
N00046
Mutation-activated KIT to PI3K signaling pathway
N00215
KITLG-KIT-RAS-ERK signaling pathway
Disease
H00003
Acute myeloid leukemia
H00031
Breast cancer
H00170
Piebaldism
H01359
Anaphylaxis
H01511
Mast-cell leukemia
H01591
Gastrotintestinal stromal tumor
Drug target
Amuvatinib (
DG01916
):
D09864
D09865
Ancestim:
D02937
Avapritinib:
D11279
Cabozantinib (
DG01670
):
D10062
D10095
Dasatinib (
DG00714
):
D03658
D06414
Dovitinib lactate:
D08907
Imatinib (
DG00710
):
D01441
D08066
Masitinib:
D10229
Midostaurin:
D05029
Motesanib (
DG01262
):
D06678
D08947
Nilotinib (
DG00716
):
D06413
D08953
Pazopanib:
D05380
Regorafenib (
DG00720
):
D10137
D10138
Ripretinib:
D11353
Semaxanib:
D05819
Sorafenib (
DG00713
):
D06272
D08524
Sunitinib (
DG00712
):
D06402
D08552
Tandutinib:
D06005
Toceranib (
DG01363
):
D08503
D08544
Vatalanib:
D06285
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
3815 (KIT)
04015 Rap1 signaling pathway
3815 (KIT)
04010 MAPK signaling pathway
3815 (KIT)
04072 Phospholipase D signaling pathway
3815 (KIT)
04151 PI3K-Akt signaling pathway
3815 (KIT)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
3815 (KIT)
09152 Endocrine system
04916 Melanogenesis
3815 (KIT)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3815 (KIT)
05230 Central carbon metabolism in cancer
3815 (KIT)
09162 Cancer: specific types
05221 Acute myeloid leukemia
3815 (KIT)
05224 Breast cancer
3815 (KIT)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3815 (KIT)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
3815 (KIT)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
3815 (KIT)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
PDGFR family [OT]
3815 (KIT)
CD molecules [BR:
hsa04090
]
Proteins
3815 (KIT)
SSDB
Motif
Pfam:
Pkinase_Tyr
Pkinase
Ig_3
ig
I-set
Ig_2
Ig_6
Ig_4
V-set
Pkinase_fungal
APH
Other DBs
NCBI-GeneID:
3815
NCBI-ProteinID:
NP_000213
OMIM:
164920
HGNC:
6342
Ensembl:
ENSG00000157404
Vega:
OTTHUMG00000128713
Pharos:
P10721
(Tclin)
UniProt:
P10721
A0A024RDA0
LinkDB
Structure
PDB:
3G0E
1T46
4HVS
1T45
4U0I
4PGZ
4K94
3G0F
4K9E
1PKG
2EC8
2E9W
Position
4q12
AA seq
976 aa
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
NT seq
2931 nt
+upstream
nt +downstream
nt
atgagaggcgctcgcggcgcctgggattttctctgcgttctgctcctactgcttcgcgtc
cagacaggctcttctcaaccatctgtgagtccaggggaaccgtctccaccatccatccat
ccaggaaaatcagacttaatagtccgcgtgggcgacgagattaggctgttatgcactgat
ccgggctttgtcaaatggacttttgagatcctggatgaaacgaatgagaataagcagaat
gaatggatcacggaaaaggcagaagccaccaacaccggcaaatacacgtgcaccaacaaa
cacggcttaagcaattccatttatgtgtttgttagagatcctgccaagcttttccttgtt
gaccgctccttgtatgggaaagaagacaacgacacgctggtccgctgtcctctcacagac
ccagaagtgaccaattattccctcaaggggtgccaggggaagcctcttcccaaggacttg
aggtttattcctgaccccaaggcgggcatcatgatcaaaagtgtgaaacgcgcctaccat
cggctctgtctgcattgttctgtggaccaggagggcaagtcagtgctgtcggaaaaattc
atcctgaaagtgaggccagccttcaaagctgtgcctgttgtgtctgtgtccaaagcaagc
tatcttcttagggaaggggaagaattcacagtgacgtgcacaataaaagatgtgtctagt
tctgtgtactcaacgtggaaaagagaaaacagtcagactaaactacaggagaaatataat
agctggcatcacggtgacttcaattatgaacgtcaggcaacgttgactatcagttcagcg
agagttaatgattctggagtgttcatgtgttatgccaataatacttttggatcagcaaat
gtcacaacaaccttggaagtagtagataaaggattcattaatatcttccccatgataaac
actacagtatttgtaaacgatggagaaaatgtagatttgattgttgaatatgaagcattc
cccaaacctgaacaccagcagtggatctatatgaacagaaccttcactgataaatgggaa
gattatcccaagtctgagaatgaaagtaatatcagatacgtaagtgaacttcatctaacg
agattaaaaggcaccgaaggaggcacttacacattcctagtgtccaattctgacgtcaat
gctgccatagcatttaatgtttatgtgaatacaaaaccagaaatcctgacttacgacagg
ctcgtgaatggcatgctccaatgtgtggcagcaggattcccagagcccacaatagattgg
tatttttgtccaggaactgagcagagatgctctgcttctgtactgccagtggatgtgcag
acactaaactcatctgggccaccgtttggaaagctagtggttcagagttctatagattct
agtgcattcaagcacaatggcacggttgaatgtaaggcttacaacgatgtgggcaagact
tctgcctattttaactttgcatttaaaggtaacaacaaagagcaaatccatccccacacc
ctgttcactcctttgctgattggtttcgtaatcgtagctggcatgatgtgcattattgtg
atgattctgacctacaaatatttacagaaacccatgtatgaagtacagtggaaggttgtt
gaggagataaatggaaacaattatgtttacatagacccaacacaacttccttatgatcac
aaatgggagtttcccagaaacaggctgagttttgggaaaaccctgggtgctggagctttc
gggaaggttgttgaggcaactgcttatggcttaattaagtcagatgcggccatgactgtc
gctgtaaagatgctcaagccgagtgcccatttgacagaacgggaagccctcatgtctgaa
ctcaaagtcctgagttaccttggtaatcacatgaatattgtgaatctacttggagcctgc
accattggagggcccaccctggtcattacagaatattgttgctatggtgatcttttgaat
tttttgagaagaaaacgtgattcatttatttgttcaaagcaggaagatcatgcagaagct
gcactttataagaatcttctgcattcaaaggagtcttcctgcagcgatagtactaatgag
tacatggacatgaaacctggagtttcttatgttgtcccaaccaaggccgacaaaaggaga
tctgtgagaataggctcatacatagaaagagatgtgactcccgccatcatggaggatgac
gagttggccctagacttagaagacttgctgagcttttcttaccaggtggcaaagggcatg
gctttcctcgcctccaagaattgtattcacagagacttggcagccagaaatatcctcctt
actcatggtcggatcacaaagatttgtgattttggtctagccagagacatcaagaatgat
tctaattatgtggttaaaggaaacgctcgactacctgtgaagtggatggcacctgaaagc
attttcaactgtgtatacacgtttgaaagtgacgtctggtcctatgggatttttctttgg
gagctgttctctttaggaagcagcccctatcctggaatgccggtcgattctaagttctac
aagatgatcaaggaaggcttccggatgctcagccctgaacacgcacctgctgaaatgtat
gacataatgaagacttgctgggatgcagatcccctaaaaagaccaacattcaagcaaatt
gttcagctaattgagaagcagatttcagagagcaccaatcatatttactccaacttagca
aactgcagccccaaccgacagaagcccgtggtagaccattctgtgcggatcaattctgtc
ggcagcaccgcttcctcctcccagcctctgcttgtgcacgacgatgtctga
DBGET
integrated database retrieval system
