KEGG ORTHOLOGY: K12326

ORTHOLOGY: K12326

Entry

K12326                      KO

Symbol

RASGRF2

Name

Ras-specific guanine nucleotide-releasing factor 2

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
   04014 Ras signaling pathway
    K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2

Other DBs

GO:

0005089

Genes

HSA:	5924(RASGRF2)

PTR:	461771(RASGRF2)

PPS:	100971503(RASGRF2)

GGO:	101125808(RASGRF2)

PON:	100172005(RASGRF2)

NLE:	100590607(RASGRF2)

HMH:	116471046(RASGRF2)

MCC:	711350(RASGRF2)

MCF:	102138771(RASGRF2)

MTHB:

126957570

MNI:	105475059(RASGRF2)

CSAB:

103223904(RASGRF2)

CATY:

105599137(RASGRF2)

PANU:

101003497(RASGRF2)

TGE:	112625910(RASGRF2)

MLEU:

105550614(RASGRF2)

RRO:	104680187(RASGRF2)

RBB:	108528890(RASGRF2)

TFN:	117064967(RASGRF2)

PTEH:

111544445(RASGRF2)

CANG:

105506265(RASGRF2)

CJC:	100402073(RASGRF2)

SBQ:	101041685(RASGRF2)

CIMI:

108288616(RASGRF2)

CSYR:

103262934(RASGRF2)

MMUR:

105872641(RASGRF2)

LCAT:

123648162(RASGRF2)

PCOQ:

105826554(RASGRF2)

OGA:	100951960(RASGRF2)

MMU:	19418(Rasgrf2)

MCAL:

110308129(Rasgrf2)

MPAH:

110329065(Rasgrf2)

RNO:	114513(Rasgrf2)

MCOC:

116083194(Rasgrf2)

ANU:	117700436(Rasgrf2)

MUN:	110565729(Rasgrf2)

CGE:

100759959

MAUA:

101828956(Rasgrf2)

PROB:

127221062(Rasgrf2)

PLEU:

114708042(Rasgrf2)

MORG:

121455820(Rasgrf2)

MFOT:

126508578

AAMP:

119810287(Rasgrf2)

NGI:	103750268(Rasgrf2)

HGL:	101698054(Rasgrf2)

CPOC:

100724898(Rasgrf2)

CCAN:

109682292(Rasgrf2)

DORD:

105985315(Rasgrf2)

DSP:	122117332(Rasgrf2)

PLOP:

125340107(Rasgrf2)

NCAR:

124987550

MMMA:

107152367(Rasgrf2)

OCU:

100338059

OPI:	101517483(RASGRF2)

TUP:	102479101(RASGRF2)

GVR:	103585600(RASGRF2)

CFA:	610203(RASGRF2)

CLUD:

112653131(RASGRF2)

VVP:	112919722(RASGRF2)

VLG:	121489355(RASGRF2)

NPO:	129521071(RASGRF2)

AML:	100473097(RASGRF2)

UMR:	103681502(RASGRF2)

UAH:	113255154(RASGRF2)

UAR:	123791523(RASGRF2)

ELK:

111148374

LLV:

125100102

MPUF:

101682209(RASGRF2)

MNP:	132028774(RASGRF2)

MLK:	131832412(RASGRF2)

NVS:	122918058(RASGRF2)

ORO:	101363140(RASGRF2)

EJU:	114217648(RASGRF2)

ZCA:	113929513(RASGRF2)

MLX:	118016953(RASGRF2)

NSU:	110589202(RASGRF2)

LWW:	102726674(RASGRF2)

FCA:	101091172(RASGRF2)

PYU:	121013786(RASGRF2)

PCOO:

112861000(RASGRF2)

PBG:	122490417(RASGRF2)

PVIV:

125174137(RASGRF2)

LRUF:

124504952

PTG:	102960805(RASGRF2)

PPAD:

109274918(RASGRF2)

PUC:

125935237

AJU:

106967946

HHV:	120222317(RASGRF2)

BTA:	524957(RASGRF2)

BOM:	102272890(RASGRF2)

BIU:	109561127(RASGRF2)

BBUB:

102389025(RASGRF2)

BBIS:

105005411(RASGRF2)

CHX:	102171602(RASGRF2)

OAS:	101121934(RASGRF2)

BTAX:

128051143(RASGRF2)

ODA:	120863312(RASGRF2)

CCAD:

122439575(RASGRF2)

MBEZ:

129557989(RASGRF2)

SSC:	100515363(RASGRF2)

CFR:	102505383(RASGRF2)

CBAI:

105064334(RASGRF2)

CDK:	105084876(RASGRF2)

VPC:	102528807(RASGRF2)

BACU:

103019128(RASGRF2)

BMUS:

118893094(RASGRF2)

LVE:	103070268(RASGRF2)

OOR:	101286231(RASGRF2)

DLE:	111184782(RASGRF2)

PCAD:

102979832(RASGRF2)

PSIU:

116751903(RASGRF2)

NASI:

112406742(RASGRF2)

ECB:	100073254(RASGRF2)

EPZ:	103549608(RASGRF2)

EAI:	106841155(RASGRF2)

MYB:	102251351(RASGRF2)

MYD:	102755145(RASGRF2)

MMYO:

118656683(RASGRF2)

MLF:	102420695(RASGRF2)

PKL:	118702799(RASGRF2)

EFUS:

103305235(RASGRF2)

MNA:	107535084(RASGRF2)

DRO:	112307470(RASGRF2)

SHON:

118977267(RASGRF2)

AJM:	119059595(RASGRF2)

PDIC:

114512995(RASGRF2)

PHAS:

123824628(RASGRF2)

MMF:	118641386(RASGRF2)

PPAM:

129074653(RASGRF2)

HAI:	109388131(RASGRF2)

RFQ:	117024869(RASGRF2)

PALE:

102879500(RASGRF2)

PGIG:

120612491(RASGRF2)

PVP:	105303773(RASGRF2)

RAY:	107499323(RASGRF2)

MJV:	108387895(RASGRF2)

TOD:	119260873(RASGRF2)

SARA:

101546988(RASGRF2)

SETR:

125997691(RASGRF2)

TMU:

101351582

ETF:	101644988(RASGRF2)

DNM:	101435283(RASGRF2)

MDO:	100012277(RASGRF2)

GAS:	123236535(RASGRF2)

SHR:	100916434(RASGRF2)

AFZ:

127559161

PCW:	110222581(RASGRF2)

OAA:	100077219(RASGRF2)

GGA:	100859132(RASGRF2)

PCOC:

116235327(RASGRF2)

MGP:	104915282(RASGRF2)

CJO:	107306541(RASGRF2)

TPAI:

128089272(RASGRF2)

LMUT:

125686702(RASGRF2)

NMEL:

110389871(RASGRF2)

APLA:

101797650(RASGRF2)

ACYG:

106042714(RASGRF2)

CATA:

118258647(RASGRF2)

AFUL:

116500532(RASGRF2)

TGU:	101233532(RASGRF2)

LSR:	110482512(RASGRF2)

SCAN:

103823070(RASGRF2)

PMOA:

120496169(RASGRF2)

OTC:	121347760(RASGRF2)

PRUF:

121351289(RASGRF2)

GFR:	102037623(RASGRF2)

FAB:	101810969(RASGRF2)

OMA:	130265322(RASGRF2)

PHI:	102112765(RASGRF2)

PMAJ:

107198175(RASGRF2)

CCAE:

111941576(RASGRF2)

CCW:	104695828(RASGRF2)

CBRC:

103618989(RASGRF2)

ETL:	114056101(RASGRF2)

ZAB:	102063388(RASGRF2)

SVG:	106861524(RASGRF2)

MMEA:

130583968(RASGRF2)

HRT:	120765844(RASGRF2)

FPG:	101924613(RASGRF2)

FCH:	102047711(RASGRF2)

CLV:	102092075(RASGRF2)

EGZ:	104128351(RASGRF2)

NNI:	104022998(RASGRF2)

PCAO:

104043679

ACUN:

113490211(RASGRF2)

TALA:

104357147(RASGRF2)

PADL:

103923436(RASGRF2)

AFOR:

103900358(RASGRF2)

ACHC:

115336937(RASGRF2)

HALD:

104324216(RASGRF2)

HLE:	104838362(RASGRF2)

AGEN:

126036510

GCL:

127027137

CCRI:

104165143(RASGRF2)

CSTI:

104553841(RASGRF2)

MUI:	104543462(RASGRF2)

FGA:	104081566(RASGRF2)

LDI:	104352999(RASGRF2)

MNB:	103772787(RASGRF2)

OHA:	104335526(RASGRF2)

NNT:	104408823(RASGRF2)

SHAB:

115600860(RASGRF2)

DPUB:

104309374(RASGRF2)

ACAR:

104526637(RASGRF2)

CPEA:

104398316(RASGRF2)

AVIT:

104279759(RASGRF2)

CVF:	104288131(RASGRF2)

RTD:	128902318(RASGRF2)

CUCA:

104058735(RASGRF2)

TEO:

104384353

BRHI:

104498956(RASGRF2)

AROW:

112968327(RASGRF2)

NPD:	112944556(RASGRF2)

TGT:	104573552 104574298(RASGRF2)

DNE:	112983669(RASGRF2)

SCAM:

104152904(RASGRF2)

ASN:	102387043(RASGRF2)

AMJ:	102560996(RASGRF2)

CPOO:

109308069(RASGRF2)

GGN:	109297278(RASGRF2)

PSS:	102458999(RASGRF2)

CMY:	102943951(RASGRF2)

CCAY:

125636853(RASGRF2)

DCC:	119856106(RASGRF2)

CPIC:

101934308(RASGRF2)

TST:	117879128(RASGRF2)

CABI:

116832848(RASGRF2)

MRV:	120408715(RASGRF2)

ACS:	100554801(rasgrf2)

ASAO:

132767109(RASGRF2)

PVT:	110077348(RASGRF2)

SUND:

121920662(RASGRF2)

PBI:	103062438(RASGRF2)

PMUR:

107286318(RASGRF2)

CTIG:

120297735(RASGRF2)

TSR:	106551898(RASGRF2)

PGUT:

117679344(RASGRF2)

APRI:

131191273(RASGRF2)

PTEX:

113448038(RASGRF2)

NSS:	113414119(RASGRF2)

VKO:	123031590(RASGRF2)

PMUA:

114606536(RASGRF2)

PRAF:

128423735(RASGRF2)

ZVI:	118076765(RASGRF2)

HCG:	128342967(RASGRF2)

GJA:	107124620(RASGRF2)

STOW:

125436377(RASGRF2)

EMC:	129334972(RASGRF2)

XLA:	108707246 108717634

XTR:	100486502(rasgrf2)

NPR:	108794206(RASGRF2)

RTEM:

120930441(RASGRF2)

BBUF:

120992488(RASGRF2)

BGAR:

122924686(RASGRF2)

MUO:	115463113(RASGRF2)

GSH:	117350255(RASGRF2)

DRE:	553520(rasgrf2b) 558859(rasgrf2a)

SRX:	107720279 107751733 107756301

SANH:

107665758 107699723(rasgrf2) 107703251

SGH:	107548987 107555492(rasgrf2) 107587539 107602219

CCAR:

109056230 109067818 109096399

CAUA:

113049618(rasgrf2) 113054730 113080372

CGIB:

127958211 127998696 128020846

PTET:

122333831(rasgrf2a) 122345461(rasgrf2b)

LROH:

127164801(rasgrf2b) 127172002(rasgrf2a)

OMC:	131540942(rasgrf2b) 131548776(rasgrf2a)

PPRM:

120471961(rasgrf2b) 120483144(rasgrf2a)

RKG:	130072606(rasgrf2b) 130075900(rasgrf2a)

MAMB:

125262487(rasgrf2a) 125267518(rasgrf2b)

CIDE:

127513526 127520301

MASI:

127428120 127433956 127436449

TROS:

130545855(rasgrf2a)

TDW:	130411588(rasgrf2a)

MANU:

129446434(rasgrf2a)

IPU:	108255331(rasgrf2b) 108276977(rasgrf2a)

IFU:	128599338(rasgrf2b) 128620575(rasgrf2a)

PHYP:

113537185 113544836

SMEO:

124380797(rasgrf2b) 124393321(rasgrf2a)

TFD:	113637580(rasgrf2b) 113638444(rasgrf2a)

TVC:	132855259(rasgrf2b) 132863344(rasgrf2a)

AMEX:

103038226(rasgrf2)

CMAO:

118824275(rasgrf2a) 118827113(rasgrf2b)

EEE:	113574960 113584383

CHAR:

105901165(rasgrf2b) 105911801(rasgrf2a)

TRU:	101066488 101076078(rasgrf2)

TFS:	130517201(rasgrf2a) 130525412

TNG:	GSTEN00025307G001 GSTEN00028605G001 GSTEN00028606G001

LCO:	104930130 104936934

NCC:	104948037 104955863(rasgrf2)

TBEN:

117472725(rasgrf2b) 117476825(rasgrf2a)

CGOB:

115013794 115016440

PGEO:

117451863(rasgrf2b) 117456435(rasgrf2a)

GACU:

117551291(rasgrf2a) 117560953(rasgrf2b)

EMAC:

134868212(rasgrf2a) 134873016(rasgrf2b)

ELY:	117252860(rasgrf2b) 117269172(rasgrf2a)

EFO:	125890593 125906048(rasgrf2a)

PLEP:

121944391 121959791

SLUC:

116051008(rasgrf2a) 116054054(rasgrf2b)

ECRA:

117944754(rasgrf2b) 117959126(rasgrf2a)

ESP:	116690095(rasgrf2) 116704319

PFLV:

114555854(rasgrf2) 114571098

GAT:	120831075(rasgrf2b) 120831786(rasgrf2a)

PPUG:

119224535 119226422(rasgrf2a)

AFB:	129101100(rasgrf2b) 129102272(rasgrf2a)

CLUM:

117736475(rasgrf2b) 117740591(rasgrf2a)

PSWI:

130197364(rasgrf2b) 130204873(rasgrf2a)

MSAM:

119891634(rasgrf2b) 119914532(rasgrf2a)

SCHU:

122865384(rasgrf2a) 122876259(rasgrf2b)

CUD:	121509372(rasgrf2b) 121524796(rasgrf2a)

ALAT:

119020193(rasgrf2b) 119029635(rasgrf2a)

MZE:	101486672 101487894

ONL:	100694890 100703635(rasgrf2)

OAU:	116328383(rasgrf2b) 116333628(rasgrf2a)

OLA:	101156500(rasgrf2) 101157792

OML:	112148655(rasgrf2b) 112163146(rasgrf2a)

CSAI:

133450651(rasgrf2b) 133455121(rasgrf2a)

XMA:	102225925 102228089

XCO:	114149382 114154958

XHE:	116724269 116730402(rasgrf2)

PRET:

103470072(rasgrf2) 103473221

PFOR:

103141743(rasgrf2) 103151775

PLAI:

106935675 106956814(rasgrf2)

PMEI:

106904272 106932652

GAF:	122819335(rasgrf2a) 122826885(rasgrf2b)

PPRL:

129366107(rasgrf2b) 129379822(rasgrf2a)

CVG:	107092330 107101745

CTUL:

119778585 119798597(rasgrf2b)

GMU:	124872078(rasgrf2a) 124877720(rasgrf2b)

NFU:	107374468 107394169(rasgrf2) 107395761

KMR:	108233744(rasgrf2b) 108245394(rasgrf2a)

ALIM:

106513653(rasgrf2) 106522196

NWH:	119413260(rasgrf2b) 119425084

AOCE:

111564700(rasgrf2) 111583377

MCEP:

124996347(rasgrf2a) 125012511(rasgrf2b)

CSEM:

103389947 103397623

POV:	109625983 109636944

SSEN:

122758451 122769673(rasgrf2b)

HHIP:

117768005(rasgrf2b) 117771231(rasgrf2a)

HSP:	118115683(rasgrf2b) 118125732(rasgrf2a)

SMAU:

118301381 118313500(rasgrf2b)

LCF:	108882003(rasgrf2b) 108897647

SDU:	111237760(rasgrf2)

SLAL:

111661021(rasgrf2) 111666035

XGL:	120804731(rasgrf2b) 120806207(rasgrf2a)

HCQ:	109507169 109527343

SSCV:

125979365 125993854

SBIA:

133491260(rasgrf2a) 133499785

PEE:	133399945 133413417(rasgrf2a)

PTAO:

133464953(rasgrf2a) 133475174(rasgrf2b)

BPEC:

110153798 110172331

MALB:

109952173 109956609(rasgrf2)

BSPL:

114866918(rasgrf2a)

SJO:	128364565(rasgrf2b) 128380689

SASA:

106561157 106568132

STRU:

115149278 115159279 115164089

OTW:	112219751 112248892(rasgrf2b) 112257267

OMY:	110522941 110526906(rasgrf2b) 110536806

OGO:	123999349 124034010 124048709(rasgrf2a)

ONE:	115111946(rasgrf2) 115117660 115121362

OKI:	109868856 109883986(rasgrf2) 109891718

OKE:	118388121 118393568(rasgrf2b)

SALP:

111962828 111974265(rasgrf2)

SNH:	120026513 120044158(rasgrf2b) 120044975

CCLU:

121582225 121584565(rasgrf2b)

ELS:	105014758(rasgrf2)

SFM:	108938999(rasgrf2)

PKI:	111850307 111859979

AANG:

118206655(rasgrf2b) 118212137

LOC:	102699199(rasgrf2)

PSPA:

121306372 121312786

ARUT:

117403791 117404117

PSEX:

120532844(rasgrf2b)

LCM:	102361460(RASGRF2)

CMK:	103182680(rasgrf2b)

CPLA:

122559051(rasgrf2b)

HOC:	132827350(rasgrf2b)

LERI:

129694413(rasgrf2b)

PMRN:

116941917(RASGRF2)

LRJ:

CLON:

AGA:

CNS:

FVI:

MGEN:

CGIG:

TPRE:

CGLO:

FAS:

DAM:

AGIF:

DSM:

NPT:

NFB:

NLO:

NVG:

SOY:

PPYR:

DCI:

HHAL:

HVI:

MQU:	129004150 129004174

FOC:

113215129

TPAL:

117647244

DPX:	DAPPUDRAFT_10143

PJA:

HAME:

PCLA:

CQD:

PTRU:

HAZT:

LSM:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

UDV:

HRO:	HELRODRAFT_169974

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

RPHI:

OSN:

OVI:	T265_15356

ATEN:

116293877

XEN:

124459420

TAD:	TRIADDRAFT_22773

» show all

Reference

PMID:10373510

Authors

Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE, Lowy DR

Title

Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

Journal

Mol Cell Biol 19:4611-22 (1999)
DOI:10.1128/mcb.19.7.4611

Sequence

[hsa:5924]

Reference

PMID:21111786

Authors

Fernandez-Medarde A, Santos E

Title

The RasGrf family of mammalian guanine nucleotide exchange factors.

Journal

Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001

LinkDB

DBGET integrated database retrieval system