KEGG   ORTHOLOGY: K05482
Entry
K05482                      KO                                     
Symbol
IL18, IL1F4
Name
interleukin 18
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05134  Legionellosis
map05135  Yersinia infection
map05143  African trypanosomiasis
map05144  Malaria
map05152  Tuberculosis
map05164  Influenza A
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05417  Lipid and atherosclerosis
Disease
H01360  Allergic rhinitis
H01516  Adult onset Still disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05482  IL18, IL1F4; interleukin 18
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05482  IL18, IL1F4; interleukin 18
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05482  IL18, IL1F4; interleukin 18
   04623 Cytosolic DNA-sensing pathway
    K05482  IL18, IL1F4; interleukin 18
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K05482  IL18, IL1F4; interleukin 18
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05482  IL18, IL1F4; interleukin 18
   05132 Salmonella infection
    K05482  IL18, IL1F4; interleukin 18
   05131 Shigellosis
    K05482  IL18, IL1F4; interleukin 18
   05135 Yersinia infection
    K05482  IL18, IL1F4; interleukin 18
   05134 Legionellosis
    K05482  IL18, IL1F4; interleukin 18
   05152 Tuberculosis
    K05482  IL18, IL1F4; interleukin 18
  09174 Infectious disease: parasitic
   05144 Malaria
    K05482  IL18, IL1F4; interleukin 18
   05143 African trypanosomiasis
    K05482  IL18, IL1F4; interleukin 18
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05482  IL18, IL1F4; interleukin 18
   05321 Inflammatory bowel disease
    K05482  IL18, IL1F4; interleukin 18
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05482  IL18, IL1F4; interleukin 18
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05482  IL18, IL1F4; interleukin 18
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05482  IL18, IL1F4; interleukin 18
Other DBs
GO: 0045515
Genes
HSA: 3606(IL18)
PTR: 739011(IL18)
PPS: 100971499(IL18)
GGO: 101138403(IL18)
PON: 100433564(IL18)
NLE: 100585066(IL18)
MCC: 574151(IL18)
MCF: 102135101(IL18)
CSAB: 103248464(IL18)
CATY: 105588688(IL18)
PANU: 101011371(IL18)
TGE: 112605580(IL18)
RRO: 104677356(IL18)
RBB: 108536445(IL18)
PTEH: 111540136(IL18)
CJC: 100396804(IL18)
SBQ: 101027404(IL18)
CSYR: 103268016(IL18)
MMUR: 105862932(IL18)
LCAT: 123641690(IL18)
OGA: 100964386(IL18)
MMU: 16173(Il18)
MCAL: 110301583(Il18)
MPAH: 110328200(Il18)
RNO: 29197(Il18)
MCOC: 116072916(Il18)
MUN: 110562014(Il18)
CGE: 100750469(Il18)
MAUA: 101836016(Il18)
PLEU: 114690242(Il18)
NGI: 103733877(Il18)
HGL: 101702804(Il18)
CPOC: 100734451(Il18)
CCAN: 109699439(Il18)
DORD: 105980688(Il18)
DSP: 122110254(Il18)
NCAR: 124959757
OCU: 100144338(IL18)
OPI: 101536496(IL18)
TUP: 102488248(IL18)
CFA: 403796(IL18)
VVP: 112925988(IL18)
VLG: 121499279(IL18)
AML: 100484109(IL18)
UMR: 103662382(IL18)
UAH: 113260053(IL18)
UAR: 123792571(IL18)
ELK: 111153900
LLV: 125110334
MPUF: 101670212(IL18)
ORO: 101368106(IL18)
EJU: 114211321(IL18)
ZCA: 113913830(IL18)
MLX: 118013235(IL18)
FCA: 493688(IL18)
PYU: 121035384(IL18)
PBG: 122482962(IL18)
PTG: 102952004(IL18)
PPAD: 109278654(IL18)
AJU: 106986372(IL18)
HHV: 120229883(IL18)
BTA: 281249(IL18)
BOM: 102281355(IL18)
BIU: 109569934(IL18)
BBUB: 102401432(IL18)
CHX: 100861190(IL18)
OAS: 443206(IL18)
ODA: 120876254(IL18)
CCAD: 122449941(IL18)
SSC: 397057(IL18)
CFR: 102520544(IL18)
CBAI: 105080059(IL18)
CDK: 105094167(IL18)
VPC: 102540203(IL18)
BACU: 103002074(IL18)
LVE: 103087219(IL18)
OOR: 101271274(IL18)
DLE: 111166897(IL18)
PCAD: 102976313(IL18)
PSIU: 116758597(IL18)
ECB: 100034216(IL18)
EPZ: 103565880(IL18)
EAI: 106840220(IL18)
MYB: 102260649(IL18)
MYD: 102761769(IL18)
MMYO: 118664355(IL18)
MLF: 102436271(IL18)
MNA: 107531295(IL18)
PKL: 118712991(IL18)
HAI: 109388707(IL18)
DRO: 112314192(IL18)
SHON: 119000535(IL18)
AJM: 119056534(IL18)
PDIC: 114500941(IL18)
PHAS: 123819718(IL18)
MMF: 118628149(IL18)
RFQ: 117030974(IL18)
PALE: 102885001(IL18)
PGIG: 120621996(IL18)
PVP: 105295631(IL18)
RAY: 107512960(IL18)
MJV: 108401553(IL18)
TOD: 119240673(IL18)
SARA: 101559035(IL18)
LAV: 100668369(IL18)
TMU: 101348624
DNM: 101427328(IL18)
OAA: 100083773(IL18)
GGA: 395312(IL18)
PCOC: 116233212(IL18)
MGP: 100303691(IL18)
CJO: 107324129(IL18)
NMEL: 110387565(IL18)
APLA: 101802715(IL18)
ACYG: 106039774(IL18)
AFUL: 116497843(IL18)
TGU: 100217637(IL18)
LSR: 110470467(IL18)
SCAN: 103822985(IL18)
PMOA: 120508363(IL18)
OTC: 121340883(IL18)
PRUF: 121355739(IL18)
GFR: 102041240(IL18)
FAB: 101819906(IL18)
PHI: 102105580(IL18)
PMAJ: 107214402
CCAE: 111939282
CCW: 104692079(IL18)
ETL: 114065628(IL18)
ZAB: 102065493(IL18)
FPG: 101910930(IL18)
FCH: 102054449(IL18)
CLV: 102093971(IL18)
EGZ: 104125907(IL18)
NNI: 104019045(IL18)
PLET: 104615404(IL18)
ACUN: 113488534(IL18)
TALA: 104368658(IL18)
PADL: 103921543(IL18)
ACHC: 115345010(IL18)
AAM: 106496023(IL18)
AROW: 112967461(IL18)
NPD: 112948749(IL18)
DNE: 112986542(IL18)
ASN: 102369831(IL18)
AMJ: 102569730(IL18)
CPOO: 109318085(IL18)
GGN: 109292958(IL18)
PSS: 102463679(IL18)
CMY: 102933793(IL18)
CPIC: 101931104(IL18)
TST: 117868530(IL18)
CABI: 116829290(IL18)
MRV: 120375607(IL18)
ACS: 100567753
PVT: 110079396
SUND: 121934420
PBI: 103051323
PMUR: 107284513
PGUT: 117670239
VKO: 123036884
PMUA: 114585328
ZVI: 118097076
GJA: 107116145
STOW: 125441657
XTR: 100496716 108648098(il18)
NPR: 108801744
RTEM: 120915500
BBUF: 120996593
BGAR: 122926941
TRU: 445965(il-18)
NCC: 104945633
MSAM: 119882624
XMA: 102222709(il18)
PRET: 103474370(il18)
CVG: 107103272
NFU: 107380752
KMR: 108247699
HCQ: 109510913
SASA: 100196379(il18)
OMY: 100136640(il-18)
SALP: 111949364
ELS: 105008818
SFM: 108928639
PKI: 111833906
AANG: 118235124
PSPA: 121309407
LCM: 102356354(IL18)
RTP: 109919113(il18) 109919115
 » show all
Reference
PMID:8666798
  Authors
Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, Torigoe K, Tanimoto T, Fukuda S, Ikeda M, Okamura H, Kurimoto M
  Title
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.
  Journal
J Immunol 156:4274-9 (1996)
  Sequence
[hsa:3606]
Reference
  Authors
Gaggero A, De Ambrosis A, Mezzanzanica D, Piazza T, Rubartelli A, Figini M, Canevari S, Ferrini S
  Title
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
  Journal
Oncogene 23:7552-60 (2004)
DOI:10.1038/sj.onc.1208036
  Sequence
[hsa:3606]
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